An olfactory virtual reality system for spatial behaviors in mice

Detalhes bibliográficos
Autor(a) principal: Teixeira, José Miguel Gomes
Data de Publicação: 2022
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/59085
Resumo: Tese de Mestrado Integrado, Engenharia Biomédica e Biofísica (Sinais e Imagens Médicas), 2022, Universidade de Lisboa, Faculdade de Ciências
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spelling An olfactory virtual reality system for spatial behaviors in miceComportamentoNavegação espacialOlfactoRealidade virtualRealidade virtual olfactivaTeses de mestrado - 2022Domínio/Área Científica::Ciências Naturais::Ciências FísicasTese de Mestrado Integrado, Engenharia Biomédica e Biofísica (Sinais e Imagens Médicas), 2022, Universidade de Lisboa, Faculdade de CiênciasAnimals have the ability of finding their way in their environments, being able to reliably visit known sources of food or water and return to their burrow or nest. Olfaction plays a major role in the spatial navigation behaviors of animals across phyla, however little is known about how olfactory and spatial information are actually combined in the brain in order to generate those behaviors. When studying spatial navigation in laboratory conditions, scientists typically design mazes where freely-moving rodents are provided with a rule for quickly navigating to rewards distributed in the environment, but investigating how olfactory information is processed in the brain is extraordinarily challenging if one cannot account for the olfactory properties of the environment a freely-moving animal is navigating in. In order to more precisely control the spatio-temporal dynamics of olfactory stimuli in experiments involving freely-moving animals, these typically consist of odorized air flow pulses that are delivered at sparse locations in behavioral arenas, which require expensive instrumentation and increase the complexity in the physical construction of the mazes while also being inherently limited in the locations the stimuli can be provided. Here, we have developed a virtual reality system that allows for the precise control of olfactory stimulus delivery properties in head-fixed navigating mice in both open an closed-loop conditions. By nature, it allows the parameterization of both the visual and olfactory dimensions of the environment, which potentiates the comparison of behavior and neural activity of mice navigating in environments containing different visual and olfactory scenes. In addition, the system is constructed mostly from standard laboratory equipment and draws from open source solutions, promoting its adoptability in different domains of research, and contributing to improve the replicability of experiments across institutions. We validate this olfactory virtual reality system by designing a spatial navigation task where olfactory stimuli are predictive of reward location. Our results confirm the system is able to produce olfactory and visual virtual environments that are controlled by the movement of head-fixed mice in a closed-loop. Finally, to complement the behavioral data, we also present data demonstrating the compatibility of our system with cutting edge neural population recording techniques.Poo, CindyGodinho, DanielaRepositório da Universidade de LisboaTeixeira, José Miguel Gomes2023-08-30T15:11:16Z202220222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10451/59085enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:08:03Zoai:repositorio.ul.pt:10451/59085Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:09:05.527632Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv An olfactory virtual reality system for spatial behaviors in mice
title An olfactory virtual reality system for spatial behaviors in mice
spellingShingle An olfactory virtual reality system for spatial behaviors in mice
Teixeira, José Miguel Gomes
Comportamento
Navegação espacial
Olfacto
Realidade virtual
Realidade virtual olfactiva
Teses de mestrado - 2022
Domínio/Área Científica::Ciências Naturais::Ciências Físicas
title_short An olfactory virtual reality system for spatial behaviors in mice
title_full An olfactory virtual reality system for spatial behaviors in mice
title_fullStr An olfactory virtual reality system for spatial behaviors in mice
title_full_unstemmed An olfactory virtual reality system for spatial behaviors in mice
title_sort An olfactory virtual reality system for spatial behaviors in mice
author Teixeira, José Miguel Gomes
author_facet Teixeira, José Miguel Gomes
author_role author
dc.contributor.none.fl_str_mv Poo, Cindy
Godinho, Daniela
Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Teixeira, José Miguel Gomes
dc.subject.por.fl_str_mv Comportamento
Navegação espacial
Olfacto
Realidade virtual
Realidade virtual olfactiva
Teses de mestrado - 2022
Domínio/Área Científica::Ciências Naturais::Ciências Físicas
topic Comportamento
Navegação espacial
Olfacto
Realidade virtual
Realidade virtual olfactiva
Teses de mestrado - 2022
Domínio/Área Científica::Ciências Naturais::Ciências Físicas
description Tese de Mestrado Integrado, Engenharia Biomédica e Biofísica (Sinais e Imagens Médicas), 2022, Universidade de Lisboa, Faculdade de Ciências
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022-01-01T00:00:00Z
2023-08-30T15:11:16Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/59085
url http://hdl.handle.net/10451/59085
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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