Aging disrupts MANF-mediated immune modulation during skeletal muscle regeneration

Detalhes bibliográficos
Autor(a) principal: Sousa, Neuza S.
Data de Publicação: 2023
Outros Autores: Brás, Margarida F., Antunes, Inês, Lindholm, Päivi, Mendes Neves, Joana, Sousa-Victor, Pedro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/60097
Resumo: Copyright © 2023, The Author(s), under exclusive licence to Springer Nature America, Inc. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
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spelling Aging disrupts MANF-mediated immune modulation during skeletal muscle regenerationCopyright © 2023, The Author(s), under exclusive licence to Springer Nature America, Inc. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.Age-related decline in skeletal muscle regenerative capacity is multifactorial, yet the contribution of immune dysfunction to regenerative failure is unknown. Macrophages are essential for effective debris clearance and muscle stem cell activity during muscle regeneration, but the regulatory mechanisms governing macrophage function during muscle repair are largely unexplored. Here, we uncover a new mechanism of immune modulation operating during skeletal muscle regeneration that is disrupted in aged animals and relies on the regulation of macrophage function. The immune modulator mesencephalic astrocyte-derived neurotrophic factor (MANF) is induced following muscle injury in young mice but not in aged animals, and its expression is essential for regenerative success. Regenerative impairments in aged muscle are associated with defects in the repair-associated myeloid response similar to those found in MANF-deficient models and could be improved through MANF delivery. We propose that restoring MANF levels is a viable strategy to improve myeloid response and regenerative capacity in aged muscle.This work was supported by EMBO (IG4448 to P.S.V.) and FCT (PTDC/MED-OUT/8010/2020 and EXPL/MED-OUT/1601/2021 to P.S.V. and J.N.). P.S.V. was supported by ‘la caixa’ Foundation Junior Leader Fellowship (LCF/BQ/PI19/11690006). J.N. was supported by an assistant research contract from FCT (2021.03843.CEECIND). P.L. was supported by the Academy of Finland (grant 343299) and by the Jane and Aatos Erkko Foundation.Nature ResearchRepositório da Universidade de LisboaSousa, Neuza S.Brás, Margarida F.Antunes, InêsLindholm, PäiviMendes Neves, JoanaSousa-Victor, Pedro2023-10-31T14:56:29Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/60097engNature Aging, volume 3, pages 585–599 (2023)10.1038/s43587-023-00382-52662-8465info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:09:37Zoai:repositorio.ul.pt:10451/60097Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:09:52.516273Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Aging disrupts MANF-mediated immune modulation during skeletal muscle regeneration
title Aging disrupts MANF-mediated immune modulation during skeletal muscle regeneration
spellingShingle Aging disrupts MANF-mediated immune modulation during skeletal muscle regeneration
Sousa, Neuza S.
title_short Aging disrupts MANF-mediated immune modulation during skeletal muscle regeneration
title_full Aging disrupts MANF-mediated immune modulation during skeletal muscle regeneration
title_fullStr Aging disrupts MANF-mediated immune modulation during skeletal muscle regeneration
title_full_unstemmed Aging disrupts MANF-mediated immune modulation during skeletal muscle regeneration
title_sort Aging disrupts MANF-mediated immune modulation during skeletal muscle regeneration
author Sousa, Neuza S.
author_facet Sousa, Neuza S.
Brás, Margarida F.
Antunes, Inês
Lindholm, Päivi
Mendes Neves, Joana
Sousa-Victor, Pedro
author_role author
author2 Brás, Margarida F.
Antunes, Inês
Lindholm, Päivi
Mendes Neves, Joana
Sousa-Victor, Pedro
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Sousa, Neuza S.
Brás, Margarida F.
Antunes, Inês
Lindholm, Päivi
Mendes Neves, Joana
Sousa-Victor, Pedro
description Copyright © 2023, The Author(s), under exclusive licence to Springer Nature America, Inc. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
publishDate 2023
dc.date.none.fl_str_mv 2023-10-31T14:56:29Z
2023
2023-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/60097
url http://hdl.handle.net/10451/60097
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Nature Aging, volume 3, pages 585–599 (2023)
10.1038/s43587-023-00382-5
2662-8465
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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