Impact of rotavirus vaccination on diarrheal hospitalizations in children younger than 5 years of age in a rural southern Mozambique

Detalhes bibliográficos
Autor(a) principal: Manjate, Filomena
Data de Publicação: 2022
Outros Autores: Quintó, Llorenç, Chirinda, Percina, Acácio, Sozinho, Garrine, Marcelino, Vubil, Delfino, Nhampossa, Tacilta, João, Eva D., Nhacolo, Arsénio, Cossa, Anelsio, Massora, Sérgio, Bambo, Gizela, Bassat, Quique, Kotloff, Karen, Levine, Myron, Alonso, Pedro L., Tate, Jacqueline E., Parashar, Umesh, Mwenda, Jason M., Mandomando, Inácio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/148284
Resumo: Funding Information: We thank the participants in this study and their parents for allowing the collection of samples and data. The authors would also like to thank all Centro de Investigação em Saúde de Manhiça (CISM) staff particularly those supporting Diarrheal Disease Research Area and Manhiça District Hospital. Core funding for CISM is provided by the Spanish Agency for International Cooperation and Development (AECID). ISGlobal receives support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019-2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. The GEMS study was supported by the Bill & Melinda Gates Foundation (Project OPP 38874). The impact of rotavirus study was supported by GAVI funds through Centers for Disease Control and Prevention Foundation (CDCF), Atlanta & World Health Organization, Regional Offices for Africa (WHO AFRO). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The findings and conclusions of this report are those of the authors and do not necessarily represent the official position of the US Centers for Disease Control and Prevention and World Health Organization. The authors declare no conflict of interest. Funding Information: We thank the participants in this study and their parents for allowing the collection of samples and data. The authors would also like to thank all Centro de Investigação em Saúde de Manhiça (CISM) staff particularly those supporting Diarrheal Disease Research Area and Manhiça District Hospital. Core funding for CISM is provided by the Spanish Agency for International Cooperation and Development (AECID). ISGlobal receives support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019-2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. The GEMS study was supported by the Bill & Melinda Gates Foundation (Project OPP 38874). The impact of rotavirus study was supported by GAVI funds through Centers for Disease Control and Prevention Foundation (CDCF), Atlanta & World Health Organization, Regional Offices for Africa (WHO AFRO). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2022
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spelling Impact of rotavirus vaccination on diarrheal hospitalizations in children younger than 5 years of age in a rural southern MozambiqueDiarrheaManhiçaMozambiqueRotavirusVaccine impactRA0421 Public health. Hygiene. Preventive MedicineRJ101 Child Health. Child health servicesRC Internal medicineMolecular MedicineImmunology and Microbiology(all)veterinary(all)Public Health, Environmental and Occupational HealthInfectious DiseasesSDG 3 - Good Health and Well-beingSDG 10 - Reduced InequalitiesFunding Information: We thank the participants in this study and their parents for allowing the collection of samples and data. The authors would also like to thank all Centro de Investigação em Saúde de Manhiça (CISM) staff particularly those supporting Diarrheal Disease Research Area and Manhiça District Hospital. Core funding for CISM is provided by the Spanish Agency for International Cooperation and Development (AECID). ISGlobal receives support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019-2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. The GEMS study was supported by the Bill & Melinda Gates Foundation (Project OPP 38874). The impact of rotavirus study was supported by GAVI funds through Centers for Disease Control and Prevention Foundation (CDCF), Atlanta & World Health Organization, Regional Offices for Africa (WHO AFRO). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The findings and conclusions of this report are those of the authors and do not necessarily represent the official position of the US Centers for Disease Control and Prevention and World Health Organization. The authors declare no conflict of interest. Funding Information: We thank the participants in this study and their parents for allowing the collection of samples and data. The authors would also like to thank all Centro de Investigação em Saúde de Manhiça (CISM) staff particularly those supporting Diarrheal Disease Research Area and Manhiça District Hospital. Core funding for CISM is provided by the Spanish Agency for International Cooperation and Development (AECID). ISGlobal receives support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019-2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. The GEMS study was supported by the Bill & Melinda Gates Foundation (Project OPP 38874). The impact of rotavirus study was supported by GAVI funds through Centers for Disease Control and Prevention Foundation (CDCF), Atlanta & World Health Organization, Regional Offices for Africa (WHO AFRO). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2022Background: Rotavirus vaccine (Rotarix®) was introduced in Mozambique through its Expanded Program of Immunization in September 2015. We assessed the impact of rotavirus vaccination on childhood gastroenteritis-associated hospitalizations post-vaccine introduction in a high HIV prevalence rural setting of southern Mozambique. Methods: We reviewed and compared the trend of hospitalizations (prevalence) and incidence rates of acute gastroenteritis (AGE), and rotavirus associated-diarrhea (laboratory confirmed rotavirus) in pre- (January 2008–August 2015) and post-rotavirus vaccine introduction periods (September 2015–December 2020), among children <5 years of age admitted to Manhiça District Hospital. Results: From January 2008 to December 2020, rotavirus vaccination was found to contribute to the decline of the prevalence of AGE from 19% (95% CI: 18.14–20.44) prior to the vaccine introduction to 10% (95% CI: 8.89–11.48) in the post-introduction period, preventing 40% (95 % IE: 38–42) and 84% (95 % IE: 80–87) of the expected AGE and laboratory confirmed rotavirus cases, respectively, among infants. Similarly, the overall incidence of rotavirus was 11.8-fold lower in the post-vaccine introduction period (0.4/1000 child-years-at-risk [CYAR]; 95% CI: 0.3–0.6) compared with the pre-vaccination period (4.7/1000 CYAR; 95% CI: 4.2–5.1) with the highest reduction being observed among infants (16.8-fold lower from the 15.1/1000 CYAR in the pre-vaccine to 0.9/1000 CYAR in the post-vaccine eras). Conclusions: We documented a significant reduction in all-cause diarrhea hospitalizations and rotavirus positivity after vaccine introduction demonstrating the beneficial impact of rotavirus vaccination in a highly vulnerable population.TB, HIV and opportunistic diseases and pathogens (THOP)Global Health and Tropical Medicine (GHTM)Instituto de Higiene e Medicina Tropical (IHMT)RUNManjate, FilomenaQuintó, LlorençChirinda, PercinaAcácio, SozinhoGarrine, MarcelinoVubil, DelfinoNhampossa, TaciltaJoão, Eva D.Nhacolo, ArsénioCossa, AnelsioMassora, SérgioBambo, GizelaBassat, QuiqueKotloff, KarenLevine, MyronAlonso, Pedro L.Tate, Jacqueline E.Parashar, UmeshMwenda, Jason M.Mandomando, Inácio2023-01-27T22:19:35Z2022-10-192022-10-19T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9application/pdfhttp://hdl.handle.net/10362/148284eng0264-410XPURE: 50662775https://doi.org/10.1016/j.vaccine.2022.09.050info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:29:41Zoai:run.unl.pt:10362/148284Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:53:18.531771Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Impact of rotavirus vaccination on diarrheal hospitalizations in children younger than 5 years of age in a rural southern Mozambique
title Impact of rotavirus vaccination on diarrheal hospitalizations in children younger than 5 years of age in a rural southern Mozambique
spellingShingle Impact of rotavirus vaccination on diarrheal hospitalizations in children younger than 5 years of age in a rural southern Mozambique
Manjate, Filomena
Diarrhea
Manhiça
Mozambique
Rotavirus
Vaccine impact
RA0421 Public health. Hygiene. Preventive Medicine
RJ101 Child Health. Child health services
RC Internal medicine
Molecular Medicine
Immunology and Microbiology(all)
veterinary(all)
Public Health, Environmental and Occupational Health
Infectious Diseases
SDG 3 - Good Health and Well-being
SDG 10 - Reduced Inequalities
title_short Impact of rotavirus vaccination on diarrheal hospitalizations in children younger than 5 years of age in a rural southern Mozambique
title_full Impact of rotavirus vaccination on diarrheal hospitalizations in children younger than 5 years of age in a rural southern Mozambique
title_fullStr Impact of rotavirus vaccination on diarrheal hospitalizations in children younger than 5 years of age in a rural southern Mozambique
title_full_unstemmed Impact of rotavirus vaccination on diarrheal hospitalizations in children younger than 5 years of age in a rural southern Mozambique
title_sort Impact of rotavirus vaccination on diarrheal hospitalizations in children younger than 5 years of age in a rural southern Mozambique
author Manjate, Filomena
author_facet Manjate, Filomena
Quintó, Llorenç
Chirinda, Percina
Acácio, Sozinho
Garrine, Marcelino
Vubil, Delfino
Nhampossa, Tacilta
João, Eva D.
Nhacolo, Arsénio
Cossa, Anelsio
Massora, Sérgio
Bambo, Gizela
Bassat, Quique
Kotloff, Karen
Levine, Myron
Alonso, Pedro L.
Tate, Jacqueline E.
Parashar, Umesh
Mwenda, Jason M.
Mandomando, Inácio
author_role author
author2 Quintó, Llorenç
Chirinda, Percina
Acácio, Sozinho
Garrine, Marcelino
Vubil, Delfino
Nhampossa, Tacilta
João, Eva D.
Nhacolo, Arsénio
Cossa, Anelsio
Massora, Sérgio
Bambo, Gizela
Bassat, Quique
Kotloff, Karen
Levine, Myron
Alonso, Pedro L.
Tate, Jacqueline E.
Parashar, Umesh
Mwenda, Jason M.
Mandomando, Inácio
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv TB, HIV and opportunistic diseases and pathogens (THOP)
Global Health and Tropical Medicine (GHTM)
Instituto de Higiene e Medicina Tropical (IHMT)
RUN
dc.contributor.author.fl_str_mv Manjate, Filomena
Quintó, Llorenç
Chirinda, Percina
Acácio, Sozinho
Garrine, Marcelino
Vubil, Delfino
Nhampossa, Tacilta
João, Eva D.
Nhacolo, Arsénio
Cossa, Anelsio
Massora, Sérgio
Bambo, Gizela
Bassat, Quique
Kotloff, Karen
Levine, Myron
Alonso, Pedro L.
Tate, Jacqueline E.
Parashar, Umesh
Mwenda, Jason M.
Mandomando, Inácio
dc.subject.por.fl_str_mv Diarrhea
Manhiça
Mozambique
Rotavirus
Vaccine impact
RA0421 Public health. Hygiene. Preventive Medicine
RJ101 Child Health. Child health services
RC Internal medicine
Molecular Medicine
Immunology and Microbiology(all)
veterinary(all)
Public Health, Environmental and Occupational Health
Infectious Diseases
SDG 3 - Good Health and Well-being
SDG 10 - Reduced Inequalities
topic Diarrhea
Manhiça
Mozambique
Rotavirus
Vaccine impact
RA0421 Public health. Hygiene. Preventive Medicine
RJ101 Child Health. Child health services
RC Internal medicine
Molecular Medicine
Immunology and Microbiology(all)
veterinary(all)
Public Health, Environmental and Occupational Health
Infectious Diseases
SDG 3 - Good Health and Well-being
SDG 10 - Reduced Inequalities
description Funding Information: We thank the participants in this study and their parents for allowing the collection of samples and data. The authors would also like to thank all Centro de Investigação em Saúde de Manhiça (CISM) staff particularly those supporting Diarrheal Disease Research Area and Manhiça District Hospital. Core funding for CISM is provided by the Spanish Agency for International Cooperation and Development (AECID). ISGlobal receives support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019-2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. The GEMS study was supported by the Bill & Melinda Gates Foundation (Project OPP 38874). The impact of rotavirus study was supported by GAVI funds through Centers for Disease Control and Prevention Foundation (CDCF), Atlanta & World Health Organization, Regional Offices for Africa (WHO AFRO). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The findings and conclusions of this report are those of the authors and do not necessarily represent the official position of the US Centers for Disease Control and Prevention and World Health Organization. The authors declare no conflict of interest. Funding Information: We thank the participants in this study and their parents for allowing the collection of samples and data. The authors would also like to thank all Centro de Investigação em Saúde de Manhiça (CISM) staff particularly those supporting Diarrheal Disease Research Area and Manhiça District Hospital. Core funding for CISM is provided by the Spanish Agency for International Cooperation and Development (AECID). ISGlobal receives support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019-2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. The GEMS study was supported by the Bill & Melinda Gates Foundation (Project OPP 38874). The impact of rotavirus study was supported by GAVI funds through Centers for Disease Control and Prevention Foundation (CDCF), Atlanta & World Health Organization, Regional Offices for Africa (WHO AFRO). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2022
publishDate 2022
dc.date.none.fl_str_mv 2022-10-19
2022-10-19T00:00:00Z
2023-01-27T22:19:35Z
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PURE: 50662775
https://doi.org/10.1016/j.vaccine.2022.09.050
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