A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.1016/j.csbj.2016.04.001 |
Resumo: | The Deinococcus radiodurans bacterium is extremely resistant to ionising radiation and desiccation and can withstand a 200-fold higher radiation dose than most other bacteria with no loss of viability. The mechanisms behind this extreme resistance are not fully understood, but it is clear that several factors contribute to this phenotype. Efficient scavenging of reactive oxygen species and repair of damaged DNA are two of these. In this review, we summarise the results froma decade of structural and functional studies of the DNA repair machinery of Deinococcus radiodurans and discuss how these studies have contributed to an improved understanding of the molecular mechanisms underlying DNA repair and to the outstanding resistance of Deinococcus radiodurans to DNA damaging agents. |
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A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radioduransMajor Findings, Functional and Mechanistic Insight and ChallengesBiotechnologyBiophysicsStructural BiologyBiochemistryGeneticsComputer Science ApplicationsThe Deinococcus radiodurans bacterium is extremely resistant to ionising radiation and desiccation and can withstand a 200-fold higher radiation dose than most other bacteria with no loss of viability. The mechanisms behind this extreme resistance are not fully understood, but it is clear that several factors contribute to this phenotype. Efficient scavenging of reactive oxygen species and repair of damaged DNA are two of these. In this review, we summarise the results froma decade of structural and functional studies of the DNA repair machinery of Deinococcus radiodurans and discuss how these studies have contributed to an improved understanding of the molecular mechanisms underlying DNA repair and to the outstanding resistance of Deinococcus radiodurans to DNA damaging agents.Instituto de Tecnologia Química e Biológica António Xavier (ITQB)Molecular, Structural and Cellular Microbiology (MOSTMICRO)RUNTimmins, JoannaMoe, Elin2019-10-24T22:35:11Z2016-01-012016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9application/pdfhttps://doi.org/10.1016/j.csbj.2016.04.001eng2001-0370PURE: 4059990http://www.scopus.com/inward/record.url?scp=84969815928&partnerID=8YFLogxKhttps://doi.org/10.1016/j.csbj.2016.04.001info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:38:21Zoai:run.unl.pt:10362/85346Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:36:36.206571Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans Major Findings, Functional and Mechanistic Insight and Challenges |
title |
A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans |
spellingShingle |
A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans Timmins, Joanna Biotechnology Biophysics Structural Biology Biochemistry Genetics Computer Science Applications |
title_short |
A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans |
title_full |
A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans |
title_fullStr |
A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans |
title_full_unstemmed |
A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans |
title_sort |
A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans |
author |
Timmins, Joanna |
author_facet |
Timmins, Joanna Moe, Elin |
author_role |
author |
author2 |
Moe, Elin |
author2_role |
author |
dc.contributor.none.fl_str_mv |
Instituto de Tecnologia Química e Biológica António Xavier (ITQB) Molecular, Structural and Cellular Microbiology (MOSTMICRO) RUN |
dc.contributor.author.fl_str_mv |
Timmins, Joanna Moe, Elin |
dc.subject.por.fl_str_mv |
Biotechnology Biophysics Structural Biology Biochemistry Genetics Computer Science Applications |
topic |
Biotechnology Biophysics Structural Biology Biochemistry Genetics Computer Science Applications |
description |
The Deinococcus radiodurans bacterium is extremely resistant to ionising radiation and desiccation and can withstand a 200-fold higher radiation dose than most other bacteria with no loss of viability. The mechanisms behind this extreme resistance are not fully understood, but it is clear that several factors contribute to this phenotype. Efficient scavenging of reactive oxygen species and repair of damaged DNA are two of these. In this review, we summarise the results froma decade of structural and functional studies of the DNA repair machinery of Deinococcus radiodurans and discuss how these studies have contributed to an improved understanding of the molecular mechanisms underlying DNA repair and to the outstanding resistance of Deinococcus radiodurans to DNA damaging agents. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-01-01 2016-01-01T00:00:00Z 2019-10-24T22:35:11Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.1016/j.csbj.2016.04.001 |
url |
https://doi.org/10.1016/j.csbj.2016.04.001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2001-0370 PURE: 4059990 http://www.scopus.com/inward/record.url?scp=84969815928&partnerID=8YFLogxK https://doi.org/10.1016/j.csbj.2016.04.001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
9 application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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