Iodine increases and predicts incidence of thyroiditis in NOD mice : histopathological and ultrastructural study
Autor(a) principal: | |
---|---|
Data de Publicação: | 2013 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/25428 |
Resumo: | Prolonged intake of large amounts of iodine has been reported to increase the incidence of hypothyroidism in humans, as well as in animals which are prone to spontaneously developing autoimmune thyroiditis. We sought to investigate the histopathological consequences of large amounts of dietary iodine on the thyroid gland and observe the occurrence of lymphocytic infiltration associated with the time of exposure to iodine. An experimental model using non-obese diabetic (NOD) mice was analyzed. A potassium iodide intake of 0.2 mg/animal/day was administered via drinking water, in experimental groups of 60 and 90 days (EG60 and EG90). Distended rough endoplasmic reticulum, degenerated mitochondria, debris and amorphous spaces or ‘ill-defined’ spaces were observed with electron microscopy (EM). Lymphocyte infiltration was observed in the two groups and the time of exposure to iodine did not increase the appearance of lymphocyte infiltration but significantly associated with the development of necrosis. The results of the present study demonstrated that the NOD mouse is a feasible experimental model for thyroiditis induced by iodine administration and may represent an opportunity to analyze the steps and factors associated with genetic autoimmune thyroiditis. High doses of ingested iodine were observed to precdict and increase the incidence of the thyroiditis process. |
id |
RCAP_0c7087f495ca8bc11a26931dfe95f7ef |
---|---|
oai_identifier_str |
oai:repositorium.sdum.uminho.pt:1822/25428 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Iodine increases and predicts incidence of thyroiditis in NOD mice : histopathological and ultrastructural studyAutoimmunityExperimental autoimmune thyroiditisIodineIodine-induced thyroiditisLymphocytic infiltrationNon-obese diabetic miceThyroiditisScience & TechnologyProlonged intake of large amounts of iodine has been reported to increase the incidence of hypothyroidism in humans, as well as in animals which are prone to spontaneously developing autoimmune thyroiditis. We sought to investigate the histopathological consequences of large amounts of dietary iodine on the thyroid gland and observe the occurrence of lymphocytic infiltration associated with the time of exposure to iodine. An experimental model using non-obese diabetic (NOD) mice was analyzed. A potassium iodide intake of 0.2 mg/animal/day was administered via drinking water, in experimental groups of 60 and 90 days (EG60 and EG90). Distended rough endoplasmic reticulum, degenerated mitochondria, debris and amorphous spaces or ‘ill-defined’ spaces were observed with electron microscopy (EM). Lymphocyte infiltration was observed in the two groups and the time of exposure to iodine did not increase the appearance of lymphocyte infiltration but significantly associated with the development of necrosis. The results of the present study demonstrated that the NOD mouse is a feasible experimental model for thyroiditis induced by iodine administration and may represent an opportunity to analyze the steps and factors associated with genetic autoimmune thyroiditis. High doses of ingested iodine were observed to precdict and increase the incidence of the thyroiditis process.Spandidos PublicationsUniversidade do MinhoVecchiatt, Stella Maria PedrossianGuzzo, Maria LuisaCaldini, Elia GarciaBisi, HélioLongatto Filho, AdhemarLin, Chin Jia2013-022013-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/25428eng1792-098110.3892/etm.2012.826http://www.medical-journals-links.com/experimental-medicine-clinical-trials-journals.phpinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:01:54Zoai:repositorium.sdum.uminho.pt:1822/25428Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:51:52.318319Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Iodine increases and predicts incidence of thyroiditis in NOD mice : histopathological and ultrastructural study |
title |
Iodine increases and predicts incidence of thyroiditis in NOD mice : histopathological and ultrastructural study |
spellingShingle |
Iodine increases and predicts incidence of thyroiditis in NOD mice : histopathological and ultrastructural study Vecchiatt, Stella Maria Pedrossian Autoimmunity Experimental autoimmune thyroiditis Iodine Iodine-induced thyroiditis Lymphocytic infiltration Non-obese diabetic mice Thyroiditis Science & Technology |
title_short |
Iodine increases and predicts incidence of thyroiditis in NOD mice : histopathological and ultrastructural study |
title_full |
Iodine increases and predicts incidence of thyroiditis in NOD mice : histopathological and ultrastructural study |
title_fullStr |
Iodine increases and predicts incidence of thyroiditis in NOD mice : histopathological and ultrastructural study |
title_full_unstemmed |
Iodine increases and predicts incidence of thyroiditis in NOD mice : histopathological and ultrastructural study |
title_sort |
Iodine increases and predicts incidence of thyroiditis in NOD mice : histopathological and ultrastructural study |
author |
Vecchiatt, Stella Maria Pedrossian |
author_facet |
Vecchiatt, Stella Maria Pedrossian Guzzo, Maria Luisa Caldini, Elia Garcia Bisi, Hélio Longatto Filho, Adhemar Lin, Chin Jia |
author_role |
author |
author2 |
Guzzo, Maria Luisa Caldini, Elia Garcia Bisi, Hélio Longatto Filho, Adhemar Lin, Chin Jia |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Vecchiatt, Stella Maria Pedrossian Guzzo, Maria Luisa Caldini, Elia Garcia Bisi, Hélio Longatto Filho, Adhemar Lin, Chin Jia |
dc.subject.por.fl_str_mv |
Autoimmunity Experimental autoimmune thyroiditis Iodine Iodine-induced thyroiditis Lymphocytic infiltration Non-obese diabetic mice Thyroiditis Science & Technology |
topic |
Autoimmunity Experimental autoimmune thyroiditis Iodine Iodine-induced thyroiditis Lymphocytic infiltration Non-obese diabetic mice Thyroiditis Science & Technology |
description |
Prolonged intake of large amounts of iodine has been reported to increase the incidence of hypothyroidism in humans, as well as in animals which are prone to spontaneously developing autoimmune thyroiditis. We sought to investigate the histopathological consequences of large amounts of dietary iodine on the thyroid gland and observe the occurrence of lymphocytic infiltration associated with the time of exposure to iodine. An experimental model using non-obese diabetic (NOD) mice was analyzed. A potassium iodide intake of 0.2 mg/animal/day was administered via drinking water, in experimental groups of 60 and 90 days (EG60 and EG90). Distended rough endoplasmic reticulum, degenerated mitochondria, debris and amorphous spaces or ‘ill-defined’ spaces were observed with electron microscopy (EM). Lymphocyte infiltration was observed in the two groups and the time of exposure to iodine did not increase the appearance of lymphocyte infiltration but significantly associated with the development of necrosis. The results of the present study demonstrated that the NOD mouse is a feasible experimental model for thyroiditis induced by iodine administration and may represent an opportunity to analyze the steps and factors associated with genetic autoimmune thyroiditis. High doses of ingested iodine were observed to precdict and increase the incidence of the thyroiditis process. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-02 2013-02-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/25428 |
url |
http://hdl.handle.net/1822/25428 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1792-0981 10.3892/etm.2012.826 http://www.medical-journals-links.com/experimental-medicine-clinical-trials-journals.php |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Spandidos Publications |
publisher.none.fl_str_mv |
Spandidos Publications |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799132292700962816 |