Tell me your weight before kidney transplant and I’ll tell you your risks

• Autor(a) principal: Costa,Joana Silva
• Data de Publicação: 2018
• Outros Autores: Ferreira,Emanuel, Leal,Rita, Romãozinho,Catarina, Santos,Lídia, Macário,Fernando, Alves,Rui, Figueiredo,Arnaldo
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692018000100004
• topic: kidney transplantation; obesity; outcomes

Introduction and aims: Overweight is highly prevalent in kidney transplant candidates and it has been associated with multiple post-transplant complications. In this study, we evaluated the occurrence of complications in the first year after kidney transplantation according to the pre-transplant Body Mass Index of the recipients. Material and methods: Retrospective analysis of patients with age &gt;18 years who underwent first kidney transplantation, between 1st January 2012 and 31st December 2015 in our Center. We analyzed 144 patients, with Body Mass Index: <25 kg/m2 in 48 patients (group 1), 25-30 Kg/m2 in 41 patients (group 2) and ≥30 kg/m2 in 55 patients (group 3), maximum of 38.3 Kg/m2. Complications in the first year after the transplant (infection, delayed graft function, surgical/urological complications, cardiovascular disease, hematologic disorders, diabetes, acute rejection, neoplasm, glomerular filtration rate and mortality). were compared between the groups. Statistical analysis was conducted using R Statistical Software version 3.2.5. Results: We found differences between the groups in recipient age and pre-transplant diabetes mellitus and in donor gender. The total number of post-transplant complications was higher in the first 3 months, and &gt;50% occurred in group 3. Infections, mostly urinary, were the main complications during the whole study period, particularly in group 3 (p<0.05). Surgical/urological complications (p<0.01) were also significantly higher in this group during the first 3 months. There was a negative correlation between Body Mass Index and Glomerular Filtration Rate at the time of discharge (regression estimate -0.83 adjusted for age, p=0.018), but not at 1 year post-transplant (regression estimate 0.02, p=0.960). This study highlights the importance of controlling weight before kidney transplantation as obesity is a risk factor for early posttransplant complications, particularly urinary infections and surgical/urological complications