Developmental expression of Shisa-2 in Xenopus laevis

Detalhes bibliográficos
Autor(a) principal: Silva, Ana-Cristina
Data de Publicação: 2006
Outros Autores: Filipe, Mario, Vitorino, Marta, Steinbeisser, Herbert, Belo, José A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.1/12125
Resumo: Shisa is an antagonist of Wnt and FGF signaling, that functions cell autonomously in the endoplasmic reticulum (ER) to inhibit the post-translational maturation of Wnt and FGF receptors. In this paper we report the isolation of a second Xenopus shisa gene (Xshisa-2). Xenopus Shisa-2shows 30.7% identity to Xshisa. RT-PCR analysis indicated that Xshisa-2 mRNA is present throughout early development and shows an increased expression during neurula and tailbud stages. At neurula stages Xenopus shisa-2 is initially expressed in the presomitic paraxial mesoderm and later in the developing somites. The expression profiles and pattern of Xshisa and Xshisa-2 differ significantly. During gastrulation only Xshisa mRNA is present in the Spemann-Mangold organizer and later on becomes restricted to the neuroectoderm and the prechordal plate.
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spelling Developmental expression of Shisa-2 in Xenopus laevisHead inductionMouse embryoWntActivationCerberusMesodermGrowthSomitogenesisInhibitionSomiteShisa is an antagonist of Wnt and FGF signaling, that functions cell autonomously in the endoplasmic reticulum (ER) to inhibit the post-translational maturation of Wnt and FGF receptors. In this paper we report the isolation of a second Xenopus shisa gene (Xshisa-2). Xenopus Shisa-2shows 30.7% identity to Xshisa. RT-PCR analysis indicated that Xshisa-2 mRNA is present throughout early development and shows an increased expression during neurula and tailbud stages. At neurula stages Xenopus shisa-2 is initially expressed in the presomitic paraxial mesoderm and later in the developing somites. The expression profiles and pattern of Xshisa and Xshisa-2 differ significantly. During gastrulation only Xshisa mRNA is present in the Spemann-Mangold organizer and later on becomes restricted to the neuroectoderm and the prechordal plate.UBC PressSapientiaSilva, Ana-CristinaFilipe, MarioVitorino, MartaSteinbeisser, HerbertBelo, José A.2018-12-07T14:58:37Z20062006-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/12125eng0214-628210.1387/ijdb.062141asinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:24:04Zoai:sapientia.ualg.pt:10400.1/12125Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:03:31.368489Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Developmental expression of Shisa-2 in Xenopus laevis
title Developmental expression of Shisa-2 in Xenopus laevis
spellingShingle Developmental expression of Shisa-2 in Xenopus laevis
Silva, Ana-Cristina
Head induction
Mouse embryo
Wnt
Activation
Cerberus
Mesoderm
Growth
Somitogenesis
Inhibition
Somite
title_short Developmental expression of Shisa-2 in Xenopus laevis
title_full Developmental expression of Shisa-2 in Xenopus laevis
title_fullStr Developmental expression of Shisa-2 in Xenopus laevis
title_full_unstemmed Developmental expression of Shisa-2 in Xenopus laevis
title_sort Developmental expression of Shisa-2 in Xenopus laevis
author Silva, Ana-Cristina
author_facet Silva, Ana-Cristina
Filipe, Mario
Vitorino, Marta
Steinbeisser, Herbert
Belo, José A.
author_role author
author2 Filipe, Mario
Vitorino, Marta
Steinbeisser, Herbert
Belo, José A.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Sapientia
dc.contributor.author.fl_str_mv Silva, Ana-Cristina
Filipe, Mario
Vitorino, Marta
Steinbeisser, Herbert
Belo, José A.
dc.subject.por.fl_str_mv Head induction
Mouse embryo
Wnt
Activation
Cerberus
Mesoderm
Growth
Somitogenesis
Inhibition
Somite
topic Head induction
Mouse embryo
Wnt
Activation
Cerberus
Mesoderm
Growth
Somitogenesis
Inhibition
Somite
description Shisa is an antagonist of Wnt and FGF signaling, that functions cell autonomously in the endoplasmic reticulum (ER) to inhibit the post-translational maturation of Wnt and FGF receptors. In this paper we report the isolation of a second Xenopus shisa gene (Xshisa-2). Xenopus Shisa-2shows 30.7% identity to Xshisa. RT-PCR analysis indicated that Xshisa-2 mRNA is present throughout early development and shows an increased expression during neurula and tailbud stages. At neurula stages Xenopus shisa-2 is initially expressed in the presomitic paraxial mesoderm and later in the developing somites. The expression profiles and pattern of Xshisa and Xshisa-2 differ significantly. During gastrulation only Xshisa mRNA is present in the Spemann-Mangold organizer and later on becomes restricted to the neuroectoderm and the prechordal plate.
publishDate 2006
dc.date.none.fl_str_mv 2006
2006-01-01T00:00:00Z
2018-12-07T14:58:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.1/12125
url http://hdl.handle.net/10400.1/12125
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0214-6282
10.1387/ijdb.062141as
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv UBC Press
publisher.none.fl_str_mv UBC Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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