GDF-9 and BMP-15 direct the follicle symphony

Detalhes bibliográficos
Autor(a) principal: Sanfins, Alexandra
Data de Publicação: 2018
Outros Autores: Rodrigues, Patricia, Albertini, David F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.21/8876
Resumo: Understanding the physiology underlying the complex dialog between the oocyte and it's surrounding somatic cells within the ovarian follicle has been crucial in defining optimal procedures for the development of clinical approaches in ART for women suffering from infertility and ovarian dysfunction. Recent studies have implicated oocyte-secreted factors like growth differentiation factor 9 (GDF-9) and bone morphogenetic protein 15 (BMP-15), members of the transforming growth factor-beta (TGFβ) superfamily, as potent regulators of folliculogenesis and ovulation. These two factors act as biologically active heterodimers or as homodimers in synergistic cooperation. Through autocrine and paracrine mechanisms, the GDF-9 and BMP-15 system have been shown to regulate growth, differentiation, and function of granulosa and thecal cells during follicular development playing a vital role in oocyte development, ovulation, fertilization, and embryonic competence. The present mini-review provides an overview of recent findings relating GDF-9 and BMP-15 as fundamental factors implicated in the regulation of ovarian function and discusses they're potential role as markers of oocyte quality in women.
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spelling GDF-9 and BMP-15 direct the follicle symphonyBMP-15FolliculogenesisGDF-9Oocyte qualityOvarian functionTGFβUnderstanding the physiology underlying the complex dialog between the oocyte and it's surrounding somatic cells within the ovarian follicle has been crucial in defining optimal procedures for the development of clinical approaches in ART for women suffering from infertility and ovarian dysfunction. Recent studies have implicated oocyte-secreted factors like growth differentiation factor 9 (GDF-9) and bone morphogenetic protein 15 (BMP-15), members of the transforming growth factor-beta (TGFβ) superfamily, as potent regulators of folliculogenesis and ovulation. These two factors act as biologically active heterodimers or as homodimers in synergistic cooperation. Through autocrine and paracrine mechanisms, the GDF-9 and BMP-15 system have been shown to regulate growth, differentiation, and function of granulosa and thecal cells during follicular development playing a vital role in oocyte development, ovulation, fertilization, and embryonic competence. The present mini-review provides an overview of recent findings relating GDF-9 and BMP-15 as fundamental factors implicated in the regulation of ovarian function and discusses they're potential role as markers of oocyte quality in women.Springer VerlagRCIPLSanfins, AlexandraRodrigues, PatriciaAlbertini, David F.2018-09-21T11:24:47Z2018-102018-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/8876engSanfins A, Rodrigues P, Albertini DF. GDF-9 and BMP-15 direct the follicle symphony. J Assist Reprod Genet. 2018;35(10):1741-50.10.1007/s10815-018-1268-4info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T09:56:53Zoai:repositorio.ipl.pt:10400.21/8876Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:17:34.504299Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv GDF-9 and BMP-15 direct the follicle symphony
title GDF-9 and BMP-15 direct the follicle symphony
spellingShingle GDF-9 and BMP-15 direct the follicle symphony
Sanfins, Alexandra
BMP-15
Folliculogenesis
GDF-9
Oocyte quality
Ovarian function
TGFβ
title_short GDF-9 and BMP-15 direct the follicle symphony
title_full GDF-9 and BMP-15 direct the follicle symphony
title_fullStr GDF-9 and BMP-15 direct the follicle symphony
title_full_unstemmed GDF-9 and BMP-15 direct the follicle symphony
title_sort GDF-9 and BMP-15 direct the follicle symphony
author Sanfins, Alexandra
author_facet Sanfins, Alexandra
Rodrigues, Patricia
Albertini, David F.
author_role author
author2 Rodrigues, Patricia
Albertini, David F.
author2_role author
author
dc.contributor.none.fl_str_mv RCIPL
dc.contributor.author.fl_str_mv Sanfins, Alexandra
Rodrigues, Patricia
Albertini, David F.
dc.subject.por.fl_str_mv BMP-15
Folliculogenesis
GDF-9
Oocyte quality
Ovarian function
TGFβ
topic BMP-15
Folliculogenesis
GDF-9
Oocyte quality
Ovarian function
TGFβ
description Understanding the physiology underlying the complex dialog between the oocyte and it's surrounding somatic cells within the ovarian follicle has been crucial in defining optimal procedures for the development of clinical approaches in ART for women suffering from infertility and ovarian dysfunction. Recent studies have implicated oocyte-secreted factors like growth differentiation factor 9 (GDF-9) and bone morphogenetic protein 15 (BMP-15), members of the transforming growth factor-beta (TGFβ) superfamily, as potent regulators of folliculogenesis and ovulation. These two factors act as biologically active heterodimers or as homodimers in synergistic cooperation. Through autocrine and paracrine mechanisms, the GDF-9 and BMP-15 system have been shown to regulate growth, differentiation, and function of granulosa and thecal cells during follicular development playing a vital role in oocyte development, ovulation, fertilization, and embryonic competence. The present mini-review provides an overview of recent findings relating GDF-9 and BMP-15 as fundamental factors implicated in the regulation of ovarian function and discusses they're potential role as markers of oocyte quality in women.
publishDate 2018
dc.date.none.fl_str_mv 2018-09-21T11:24:47Z
2018-10
2018-10-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.21/8876
url http://hdl.handle.net/10400.21/8876
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Sanfins A, Rodrigues P, Albertini DF. GDF-9 and BMP-15 direct the follicle symphony. J Assist Reprod Genet. 2018;35(10):1741-50.
10.1007/s10815-018-1268-4
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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