GDF-9 and BMP-15 direct the follicle symphony
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.21/8876 |
Resumo: | Understanding the physiology underlying the complex dialog between the oocyte and it's surrounding somatic cells within the ovarian follicle has been crucial in defining optimal procedures for the development of clinical approaches in ART for women suffering from infertility and ovarian dysfunction. Recent studies have implicated oocyte-secreted factors like growth differentiation factor 9 (GDF-9) and bone morphogenetic protein 15 (BMP-15), members of the transforming growth factor-beta (TGFβ) superfamily, as potent regulators of folliculogenesis and ovulation. These two factors act as biologically active heterodimers or as homodimers in synergistic cooperation. Through autocrine and paracrine mechanisms, the GDF-9 and BMP-15 system have been shown to regulate growth, differentiation, and function of granulosa and thecal cells during follicular development playing a vital role in oocyte development, ovulation, fertilization, and embryonic competence. The present mini-review provides an overview of recent findings relating GDF-9 and BMP-15 as fundamental factors implicated in the regulation of ovarian function and discusses they're potential role as markers of oocyte quality in women. |
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GDF-9 and BMP-15 direct the follicle symphonyBMP-15FolliculogenesisGDF-9Oocyte qualityOvarian functionTGFβUnderstanding the physiology underlying the complex dialog between the oocyte and it's surrounding somatic cells within the ovarian follicle has been crucial in defining optimal procedures for the development of clinical approaches in ART for women suffering from infertility and ovarian dysfunction. Recent studies have implicated oocyte-secreted factors like growth differentiation factor 9 (GDF-9) and bone morphogenetic protein 15 (BMP-15), members of the transforming growth factor-beta (TGFβ) superfamily, as potent regulators of folliculogenesis and ovulation. These two factors act as biologically active heterodimers or as homodimers in synergistic cooperation. Through autocrine and paracrine mechanisms, the GDF-9 and BMP-15 system have been shown to regulate growth, differentiation, and function of granulosa and thecal cells during follicular development playing a vital role in oocyte development, ovulation, fertilization, and embryonic competence. The present mini-review provides an overview of recent findings relating GDF-9 and BMP-15 as fundamental factors implicated in the regulation of ovarian function and discusses they're potential role as markers of oocyte quality in women.Springer VerlagRCIPLSanfins, AlexandraRodrigues, PatriciaAlbertini, David F.2018-09-21T11:24:47Z2018-102018-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/8876engSanfins A, Rodrigues P, Albertini DF. GDF-9 and BMP-15 direct the follicle symphony. J Assist Reprod Genet. 2018;35(10):1741-50.10.1007/s10815-018-1268-4info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T09:56:53Zoai:repositorio.ipl.pt:10400.21/8876Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:17:34.504299Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
GDF-9 and BMP-15 direct the follicle symphony |
title |
GDF-9 and BMP-15 direct the follicle symphony |
spellingShingle |
GDF-9 and BMP-15 direct the follicle symphony Sanfins, Alexandra BMP-15 Folliculogenesis GDF-9 Oocyte quality Ovarian function TGFβ |
title_short |
GDF-9 and BMP-15 direct the follicle symphony |
title_full |
GDF-9 and BMP-15 direct the follicle symphony |
title_fullStr |
GDF-9 and BMP-15 direct the follicle symphony |
title_full_unstemmed |
GDF-9 and BMP-15 direct the follicle symphony |
title_sort |
GDF-9 and BMP-15 direct the follicle symphony |
author |
Sanfins, Alexandra |
author_facet |
Sanfins, Alexandra Rodrigues, Patricia Albertini, David F. |
author_role |
author |
author2 |
Rodrigues, Patricia Albertini, David F. |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
RCIPL |
dc.contributor.author.fl_str_mv |
Sanfins, Alexandra Rodrigues, Patricia Albertini, David F. |
dc.subject.por.fl_str_mv |
BMP-15 Folliculogenesis GDF-9 Oocyte quality Ovarian function TGFβ |
topic |
BMP-15 Folliculogenesis GDF-9 Oocyte quality Ovarian function TGFβ |
description |
Understanding the physiology underlying the complex dialog between the oocyte and it's surrounding somatic cells within the ovarian follicle has been crucial in defining optimal procedures for the development of clinical approaches in ART for women suffering from infertility and ovarian dysfunction. Recent studies have implicated oocyte-secreted factors like growth differentiation factor 9 (GDF-9) and bone morphogenetic protein 15 (BMP-15), members of the transforming growth factor-beta (TGFβ) superfamily, as potent regulators of folliculogenesis and ovulation. These two factors act as biologically active heterodimers or as homodimers in synergistic cooperation. Through autocrine and paracrine mechanisms, the GDF-9 and BMP-15 system have been shown to regulate growth, differentiation, and function of granulosa and thecal cells during follicular development playing a vital role in oocyte development, ovulation, fertilization, and embryonic competence. The present mini-review provides an overview of recent findings relating GDF-9 and BMP-15 as fundamental factors implicated in the regulation of ovarian function and discusses they're potential role as markers of oocyte quality in women. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-09-21T11:24:47Z 2018-10 2018-10-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.21/8876 |
url |
http://hdl.handle.net/10400.21/8876 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Sanfins A, Rodrigues P, Albertini DF. GDF-9 and BMP-15 direct the follicle symphony. J Assist Reprod Genet. 2018;35(10):1741-50. 10.1007/s10815-018-1268-4 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Springer Verlag |
publisher.none.fl_str_mv |
Springer Verlag |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133437690380288 |