Anti-aging and neuroprotective properties of Grifola frondosa and Hericium erinaceus extracts
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | https://hdl.handle.net/1822/81026 |
Resumo: | The following supporting information can be downloaded at https://www.mdpi.com/article/10.3390/nu14204368/s1. Table S1. Analytes identified by GC/MS on the basis of match with NIST2014 library and the corresponding target ions used to quantify them. Table S2. Yeast strains used in this study. Figure S1 Calibration curve and linear regression curve for ET. Figure S2 Evaluation of interference of fungal extracts on ThT assay. Figure S3. High fungal extract concentrations are toxic for adult flies. |
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Anti-aging and neuroprotective properties of Grifola frondosa and Hericium erinaceus extractsSaccharomyces cerevisiaeα-synucleinGrifola frondosaHericium erinaceusmedicinal mushroomsParkinson’s disease (PD)Drosophila melanogasterScience & TechnologyThe following supporting information can be downloaded at https://www.mdpi.com/article/10.3390/nu14204368/s1. Table S1. Analytes identified by GC/MS on the basis of match with NIST2014 library and the corresponding target ions used to quantify them. Table S2. Yeast strains used in this study. Figure S1 Calibration curve and linear regression curve for ET. Figure S2 Evaluation of interference of fungal extracts on ThT assay. Figure S3. High fungal extract concentrations are toxic for adult flies.Nutrition has relevant consequences for human health and increasing pieces of evidence indicate that medicinal mushrooms have several beneficial effects. One of the main issues in Western countries is represented by the challenges of aging and age-related diseases, such as neurodegenerative disorders. Among these, Parkinson’s disease (PD) affects 10 million people worldwide and is associated with α-synuclein misfolding, also found in other pathologies collectively called synucleinopathies. Here, we show that aqueous extracts of two edible mushrooms, <i>Grifola frondosa</i> and <i>Hericium erinaceus</i>, represent a valuable source of β-glucans and exert anti-aging effects in yeast. Their beneficial effects are mediated through the inhibition of the Ras/PKA pathway, with increased expression of heat shock proteins, along with a consistent increase of both mean and maximal lifespans. These fungal extracts also reduce the toxicity of α-synuclein heterologously expressed in yeast cells, resulting in reduced ROS levels, lower α-synuclein membrane localization, and protein aggregation. The neuroprotective activity of <i>G. frondosa</i> extract was also confirmed in a PD model of <i>Drosophila melanogaster</i>. Taken together, our data suggest the use of <i>G. frondosa</i> and <i>H. erinaceus</i> as functional food to prevent aging and age-related disorders, further supporting the neuro-healthy properties of these medicinal mushroom extracts.We acknowledge financial support from the Italian Ministry of University and Research (MUR) through grant “Dipartimenti di Eccellenza 2017” to University of Milano-Bicocca, Department of Biotechnology and Biosciences. This research was also supported by the Italian Ministry of University and Research (MUR): Dipartimenti di Eccellenza Program (2018–2022) Dept. of Biology and Biotechnology “L. Spallanzani”, and Fondo di Ricerca e Giovani (FRG, University of Pavia). M.L. was supported by a fellowship from Fondazione Umberto Veronesi. R.M. was supported by a fellowship from the Italian Ministry of University and Research (MUR).Multidisciplinary Digital Publishing InstituteUniversidade do MinhoTripodi, FaridaFalletta, ErmelindaLeri, ManuelaAngeloni, CristinaBeghelli, DanielaGiusti, LauraMilanesi, RiccardoSampaio-Marques, BelémLudovico, PaulaGoppa, LorenzoRossi, PaolaSavino, ElenaBucciantini, MonicaCoccetti, Paola2022-10-182022-10-18T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/81026engTripodi, F.; Falletta, E.; Leri, M.; Angeloni, C.; Beghelli, D.; Giusti, L.; Milanesi, R.; Sampaio-Marques, B.; Ludovico, P.; Goppa, L.; Rossi, P.; Savino, E.; Bucciantini, M.; Coccetti, P. Anti-Aging and Neuroprotective Properties of Grifola frondosa and Hericium erinaceus Extracts. Nutrients 2022, 14, 4368. https://doi.org/10.3390/nu142043682072-664310.3390/nu1420436836297052https://www.mdpi.com/2072-6643/14/20/4368info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:10:37Zoai:repositorium.sdum.uminho.pt:1822/81026Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:02:16.996566Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Anti-aging and neuroprotective properties of Grifola frondosa and Hericium erinaceus extracts |
| title |
Anti-aging and neuroprotective properties of Grifola frondosa and Hericium erinaceus extracts |
| spellingShingle |
Anti-aging and neuroprotective properties of Grifola frondosa and Hericium erinaceus extracts Tripodi, Farida Saccharomyces cerevisiae α-synuclein Grifola frondosa Hericium erinaceus medicinal mushrooms Parkinson’s disease (PD) Drosophila melanogaster Science & Technology |
| title_short |
Anti-aging and neuroprotective properties of Grifola frondosa and Hericium erinaceus extracts |
| title_full |
Anti-aging and neuroprotective properties of Grifola frondosa and Hericium erinaceus extracts |
| title_fullStr |
Anti-aging and neuroprotective properties of Grifola frondosa and Hericium erinaceus extracts |
| title_full_unstemmed |
Anti-aging and neuroprotective properties of Grifola frondosa and Hericium erinaceus extracts |
| title_sort |
Anti-aging and neuroprotective properties of Grifola frondosa and Hericium erinaceus extracts |
| author |
Tripodi, Farida |
| author_facet |
Tripodi, Farida Falletta, Ermelinda Leri, Manuela Angeloni, Cristina Beghelli, Daniela Giusti, Laura Milanesi, Riccardo Sampaio-Marques, Belém Ludovico, Paula Goppa, Lorenzo Rossi, Paola Savino, Elena Bucciantini, Monica Coccetti, Paola |
| author_role |
author |
| author2 |
Falletta, Ermelinda Leri, Manuela Angeloni, Cristina Beghelli, Daniela Giusti, Laura Milanesi, Riccardo Sampaio-Marques, Belém Ludovico, Paula Goppa, Lorenzo Rossi, Paola Savino, Elena Bucciantini, Monica Coccetti, Paola |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade do Minho |
| dc.contributor.author.fl_str_mv |
Tripodi, Farida Falletta, Ermelinda Leri, Manuela Angeloni, Cristina Beghelli, Daniela Giusti, Laura Milanesi, Riccardo Sampaio-Marques, Belém Ludovico, Paula Goppa, Lorenzo Rossi, Paola Savino, Elena Bucciantini, Monica Coccetti, Paola |
| dc.subject.por.fl_str_mv |
Saccharomyces cerevisiae α-synuclein Grifola frondosa Hericium erinaceus medicinal mushrooms Parkinson’s disease (PD) Drosophila melanogaster Science & Technology |
| topic |
Saccharomyces cerevisiae α-synuclein Grifola frondosa Hericium erinaceus medicinal mushrooms Parkinson’s disease (PD) Drosophila melanogaster Science & Technology |
| description |
The following supporting information can be downloaded at https://www.mdpi.com/article/10.3390/nu14204368/s1. Table S1. Analytes identified by GC/MS on the basis of match with NIST2014 library and the corresponding target ions used to quantify them. Table S2. Yeast strains used in this study. Figure S1 Calibration curve and linear regression curve for ET. Figure S2 Evaluation of interference of fungal extracts on ThT assay. Figure S3. High fungal extract concentrations are toxic for adult flies. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-10-18 2022-10-18T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/81026 |
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https://hdl.handle.net/1822/81026 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Tripodi, F.; Falletta, E.; Leri, M.; Angeloni, C.; Beghelli, D.; Giusti, L.; Milanesi, R.; Sampaio-Marques, B.; Ludovico, P.; Goppa, L.; Rossi, P.; Savino, E.; Bucciantini, M.; Coccetti, P. Anti-Aging and Neuroprotective Properties of Grifola frondosa and Hericium erinaceus Extracts. Nutrients 2022, 14, 4368. https://doi.org/10.3390/nu14204368 2072-6643 10.3390/nu14204368 36297052 https://www.mdpi.com/2072-6643/14/20/4368 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Multidisciplinary Digital Publishing Institute |
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Multidisciplinary Digital Publishing Institute |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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