The effect of age and selenium on some biochemical parameters in rat liver
Autor(a) principal: | |
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Data de Publicação: | 1995 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10174/2817 https://doi.org/10.1007/BF02790125 |
Resumo: | Two age groups, 3 and 15 mo, were used to investigate whether age-associated changes in some parameters related to lipid peroxidation occur in the liver of male Wistar rats and to observe possible effects of dietary selenium supplementation (0.25 and 0.50 ppm) for 12 mo on the same parameters. At these experimental conditions, the most important observation was that peroxidation did not change by aging, at least until 15 mo of age. In addition, the activity of Sedependent glutathione peroxidase (GSH-Px, EC 1.11.1.9) was higher in the liver of the older animals. It is suggested that the enzyme could have a role in the unchanged hepatic peroxidation observed in aged male rats. On the other hand, an effect of dietary selenium supplementation on those parameters was not observed, probably because the selenium levels were still at an adequate plateau. |
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The effect of age and selenium on some biochemical parameters in rat liverlipid peroxidationseleiumgluthatione peroxidaserat liverTwo age groups, 3 and 15 mo, were used to investigate whether age-associated changes in some parameters related to lipid peroxidation occur in the liver of male Wistar rats and to observe possible effects of dietary selenium supplementation (0.25 and 0.50 ppm) for 12 mo on the same parameters. At these experimental conditions, the most important observation was that peroxidation did not change by aging, at least until 15 mo of age. In addition, the activity of Sedependent glutathione peroxidase (GSH-Px, EC 1.11.1.9) was higher in the liver of the older animals. It is suggested that the enzyme could have a role in the unchanged hepatic peroxidation observed in aged male rats. On the other hand, an effect of dietary selenium supplementation on those parameters was not observed, probably because the selenium levels were still at an adequate plateau.Springer, Biological Trace Element Research2011-10-31T12:11:56Z2011-10-311995-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10174/2817http://hdl.handle.net/10174/2817https://doi.org/10.1007/BF02790125por257-26147Biological Trace Element Researchndndndndmjlanca@uevora.ptnd543Santos, M.C.Rodrigues, H.Vasconcelos, S.Andrade, V.Lança, M.J.Crespo, A.M.V.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-03T18:39:27Zoai:dspace.uevora.pt:10174/2817Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:58:23.112987Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The effect of age and selenium on some biochemical parameters in rat liver |
title |
The effect of age and selenium on some biochemical parameters in rat liver |
spellingShingle |
The effect of age and selenium on some biochemical parameters in rat liver Santos, M.C. lipid peroxidation seleium gluthatione peroxidase rat liver |
title_short |
The effect of age and selenium on some biochemical parameters in rat liver |
title_full |
The effect of age and selenium on some biochemical parameters in rat liver |
title_fullStr |
The effect of age and selenium on some biochemical parameters in rat liver |
title_full_unstemmed |
The effect of age and selenium on some biochemical parameters in rat liver |
title_sort |
The effect of age and selenium on some biochemical parameters in rat liver |
author |
Santos, M.C. |
author_facet |
Santos, M.C. Rodrigues, H. Vasconcelos, S. Andrade, V. Lança, M.J. Crespo, A.M.V. |
author_role |
author |
author2 |
Rodrigues, H. Vasconcelos, S. Andrade, V. Lança, M.J. Crespo, A.M.V. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Santos, M.C. Rodrigues, H. Vasconcelos, S. Andrade, V. Lança, M.J. Crespo, A.M.V. |
dc.subject.por.fl_str_mv |
lipid peroxidation seleium gluthatione peroxidase rat liver |
topic |
lipid peroxidation seleium gluthatione peroxidase rat liver |
description |
Two age groups, 3 and 15 mo, were used to investigate whether age-associated changes in some parameters related to lipid peroxidation occur in the liver of male Wistar rats and to observe possible effects of dietary selenium supplementation (0.25 and 0.50 ppm) for 12 mo on the same parameters. At these experimental conditions, the most important observation was that peroxidation did not change by aging, at least until 15 mo of age. In addition, the activity of Sedependent glutathione peroxidase (GSH-Px, EC 1.11.1.9) was higher in the liver of the older animals. It is suggested that the enzyme could have a role in the unchanged hepatic peroxidation observed in aged male rats. On the other hand, an effect of dietary selenium supplementation on those parameters was not observed, probably because the selenium levels were still at an adequate plateau. |
publishDate |
1995 |
dc.date.none.fl_str_mv |
1995-01-01T00:00:00Z 2011-10-31T12:11:56Z 2011-10-31 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10174/2817 http://hdl.handle.net/10174/2817 https://doi.org/10.1007/BF02790125 |
url |
http://hdl.handle.net/10174/2817 https://doi.org/10.1007/BF02790125 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
257-261 47 Biological Trace Element Research nd nd nd nd mjlanca@uevora.pt nd 543 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Springer, Biological Trace Element Research |
publisher.none.fl_str_mv |
Springer, Biological Trace Element Research |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799136467105087488 |