Curcumin Inhibits Gastric Inflammation Induced by Helicobacter Pylori Infection in a Mouse Model

Detalhes bibliográficos
Autor(a) principal: Santos, António M.
Data de Publicação: 2015
Outros Autores: Lopes, Teresa, Oleastro, Mónica, Gato, Inês Vale, Floch, Pauline, Benejat, Lucie, Chaves, Paula, Pereira, Teresa, Seixas, Elsa, Machado, Jorge, Guerreiro, António S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.3390/nu7010306
Resumo: This project was funded by PTDC/SAU-OSM/66323/2006 and SFRH/BPD/34094/2006 research grants from the Fundacao para a Ciencia e a Tecnologia (FCT), Portugal.
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spelling Curcumin Inhibits Gastric Inflammation Induced by Helicobacter Pylori Infection in a Mouse ModelCurcuminH. pyloriMouse modelNutritional approachSecondary preventionFood ScienceSDG 3 - Good Health and Well-beingThis project was funded by PTDC/SAU-OSM/66323/2006 and SFRH/BPD/34094/2006 research grants from the Fundacao para a Ciencia e a Tecnologia (FCT), Portugal.Helicobacter pylori (H. pylori) infection triggers a sequence of gastric alterations starting with an inflammation of the gastric mucosa that, in some cases, evolves to gastric cancer. Efficient vaccination has not been achieved, thus it is essential to find alternative therapies, particularly in the nutritional field. The current study evaluated whether curcumin could attenuate inflammation of the gastric mucosa due to H. pylori infection. Twenty-eight C57BL/6 mice, were inoculated with the H. pylori SS1 strain; ten non-infected mice were used as controls. H. pylori infection in live mice was followed-up using a modified 13C-Urea Breath Test (13C-UBT) and quantitative real-time polymerase chain reaction (PCR) Histologically confirmed, gastritis was observed in 42% of infected non-treated mice at both 6 and 18 weeks post-infection. These mice showed an up-regulation of the expression of inflammatory cytokines and chemokines, as well as of toll-like receptors (TLRs) and MyD88, at both time points. Treatment with curcumin decreased the expression of all these mediators. No inflammation was observed by histology in this group. Curcumin treatment exerted a significant anti-inflammatory effect in H. pylori-infected mucosa, pointing to the promising role of a nutritional approach in the prevention of H. pylori induced deleterious inflammation while the eradication or prevention of colonization by effective vaccine is not available.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNSantos, António M.Lopes, TeresaOleastro, MónicaGato, Inês ValeFloch, PaulineBenejat, LucieChaves, PaulaPereira, TeresaSeixas, ElsaMachado, JorgeGuerreiro, António S.2017-09-18T22:03:19Z2015-01-062015-01-06T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article15application/pdfhttps://doi.org/10.3390/nu7010306eng1422-8599PURE: 3137852http://www.scopus.com/inward/record.url?scp=84920545584&partnerID=8YFLogxKhttps://doi.org/10.3390/nu7010306info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T17:27:44Zoai:run.unl.pt:10362/23366Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T17:27:44Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Curcumin Inhibits Gastric Inflammation Induced by Helicobacter Pylori Infection in a Mouse Model
title Curcumin Inhibits Gastric Inflammation Induced by Helicobacter Pylori Infection in a Mouse Model
spellingShingle Curcumin Inhibits Gastric Inflammation Induced by Helicobacter Pylori Infection in a Mouse Model
Santos, António M.
Curcumin
H. pylori
Mouse model
Nutritional approach
Secondary prevention
Food Science
SDG 3 - Good Health and Well-being
title_short Curcumin Inhibits Gastric Inflammation Induced by Helicobacter Pylori Infection in a Mouse Model
title_full Curcumin Inhibits Gastric Inflammation Induced by Helicobacter Pylori Infection in a Mouse Model
title_fullStr Curcumin Inhibits Gastric Inflammation Induced by Helicobacter Pylori Infection in a Mouse Model
title_full_unstemmed Curcumin Inhibits Gastric Inflammation Induced by Helicobacter Pylori Infection in a Mouse Model
title_sort Curcumin Inhibits Gastric Inflammation Induced by Helicobacter Pylori Infection in a Mouse Model
author Santos, António M.
author_facet Santos, António M.
Lopes, Teresa
Oleastro, Mónica
Gato, Inês Vale
Floch, Pauline
Benejat, Lucie
Chaves, Paula
Pereira, Teresa
Seixas, Elsa
Machado, Jorge
Guerreiro, António S.
author_role author
author2 Lopes, Teresa
Oleastro, Mónica
Gato, Inês Vale
Floch, Pauline
Benejat, Lucie
Chaves, Paula
Pereira, Teresa
Seixas, Elsa
Machado, Jorge
Guerreiro, António S.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centro de Estudos de Doenças Crónicas (CEDOC)
RUN
dc.contributor.author.fl_str_mv Santos, António M.
Lopes, Teresa
Oleastro, Mónica
Gato, Inês Vale
Floch, Pauline
Benejat, Lucie
Chaves, Paula
Pereira, Teresa
Seixas, Elsa
Machado, Jorge
Guerreiro, António S.
dc.subject.por.fl_str_mv Curcumin
H. pylori
Mouse model
Nutritional approach
Secondary prevention
Food Science
SDG 3 - Good Health and Well-being
topic Curcumin
H. pylori
Mouse model
Nutritional approach
Secondary prevention
Food Science
SDG 3 - Good Health and Well-being
description This project was funded by PTDC/SAU-OSM/66323/2006 and SFRH/BPD/34094/2006 research grants from the Fundacao para a Ciencia e a Tecnologia (FCT), Portugal.
publishDate 2015
dc.date.none.fl_str_mv 2015-01-06
2015-01-06T00:00:00Z
2017-09-18T22:03:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv https://doi.org/10.3390/nu7010306
url https://doi.org/10.3390/nu7010306
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1422-8599
PURE: 3137852
http://www.scopus.com/inward/record.url?scp=84920545584&partnerID=8YFLogxK
https://doi.org/10.3390/nu7010306
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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