Curcumin Inhibits Gastric Inflammation Induced by Helicobacter Pylori Infection in a Mouse Model
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.3390/nu7010306 |
Resumo: | This project was funded by PTDC/SAU-OSM/66323/2006 and SFRH/BPD/34094/2006 research grants from the Fundacao para a Ciencia e a Tecnologia (FCT), Portugal. |
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Curcumin Inhibits Gastric Inflammation Induced by Helicobacter Pylori Infection in a Mouse ModelCurcuminH. pyloriMouse modelNutritional approachSecondary preventionFood ScienceSDG 3 - Good Health and Well-beingThis project was funded by PTDC/SAU-OSM/66323/2006 and SFRH/BPD/34094/2006 research grants from the Fundacao para a Ciencia e a Tecnologia (FCT), Portugal.Helicobacter pylori (H. pylori) infection triggers a sequence of gastric alterations starting with an inflammation of the gastric mucosa that, in some cases, evolves to gastric cancer. Efficient vaccination has not been achieved, thus it is essential to find alternative therapies, particularly in the nutritional field. The current study evaluated whether curcumin could attenuate inflammation of the gastric mucosa due to H. pylori infection. Twenty-eight C57BL/6 mice, were inoculated with the H. pylori SS1 strain; ten non-infected mice were used as controls. H. pylori infection in live mice was followed-up using a modified 13C-Urea Breath Test (13C-UBT) and quantitative real-time polymerase chain reaction (PCR) Histologically confirmed, gastritis was observed in 42% of infected non-treated mice at both 6 and 18 weeks post-infection. These mice showed an up-regulation of the expression of inflammatory cytokines and chemokines, as well as of toll-like receptors (TLRs) and MyD88, at both time points. Treatment with curcumin decreased the expression of all these mediators. No inflammation was observed by histology in this group. Curcumin treatment exerted a significant anti-inflammatory effect in H. pylori-infected mucosa, pointing to the promising role of a nutritional approach in the prevention of H. pylori induced deleterious inflammation while the eradication or prevention of colonization by effective vaccine is not available.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNSantos, António M.Lopes, TeresaOleastro, MónicaGato, Inês ValeFloch, PaulineBenejat, LucieChaves, PaulaPereira, TeresaSeixas, ElsaMachado, JorgeGuerreiro, António S.2017-09-18T22:03:19Z2015-01-062015-01-06T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article15application/pdfhttps://doi.org/10.3390/nu7010306eng1422-8599PURE: 3137852http://www.scopus.com/inward/record.url?scp=84920545584&partnerID=8YFLogxKhttps://doi.org/10.3390/nu7010306info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T17:27:44Zoai:run.unl.pt:10362/23366Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T17:27:44Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Curcumin Inhibits Gastric Inflammation Induced by Helicobacter Pylori Infection in a Mouse Model |
title |
Curcumin Inhibits Gastric Inflammation Induced by Helicobacter Pylori Infection in a Mouse Model |
spellingShingle |
Curcumin Inhibits Gastric Inflammation Induced by Helicobacter Pylori Infection in a Mouse Model Santos, António M. Curcumin H. pylori Mouse model Nutritional approach Secondary prevention Food Science SDG 3 - Good Health and Well-being |
title_short |
Curcumin Inhibits Gastric Inflammation Induced by Helicobacter Pylori Infection in a Mouse Model |
title_full |
Curcumin Inhibits Gastric Inflammation Induced by Helicobacter Pylori Infection in a Mouse Model |
title_fullStr |
Curcumin Inhibits Gastric Inflammation Induced by Helicobacter Pylori Infection in a Mouse Model |
title_full_unstemmed |
Curcumin Inhibits Gastric Inflammation Induced by Helicobacter Pylori Infection in a Mouse Model |
title_sort |
Curcumin Inhibits Gastric Inflammation Induced by Helicobacter Pylori Infection in a Mouse Model |
author |
Santos, António M. |
author_facet |
Santos, António M. Lopes, Teresa Oleastro, Mónica Gato, Inês Vale Floch, Pauline Benejat, Lucie Chaves, Paula Pereira, Teresa Seixas, Elsa Machado, Jorge Guerreiro, António S. |
author_role |
author |
author2 |
Lopes, Teresa Oleastro, Mónica Gato, Inês Vale Floch, Pauline Benejat, Lucie Chaves, Paula Pereira, Teresa Seixas, Elsa Machado, Jorge Guerreiro, António S. |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Centro de Estudos de Doenças Crónicas (CEDOC) RUN |
dc.contributor.author.fl_str_mv |
Santos, António M. Lopes, Teresa Oleastro, Mónica Gato, Inês Vale Floch, Pauline Benejat, Lucie Chaves, Paula Pereira, Teresa Seixas, Elsa Machado, Jorge Guerreiro, António S. |
dc.subject.por.fl_str_mv |
Curcumin H. pylori Mouse model Nutritional approach Secondary prevention Food Science SDG 3 - Good Health and Well-being |
topic |
Curcumin H. pylori Mouse model Nutritional approach Secondary prevention Food Science SDG 3 - Good Health and Well-being |
description |
This project was funded by PTDC/SAU-OSM/66323/2006 and SFRH/BPD/34094/2006 research grants from the Fundacao para a Ciencia e a Tecnologia (FCT), Portugal. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-01-06 2015-01-06T00:00:00Z 2017-09-18T22:03:19Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.3390/nu7010306 |
url |
https://doi.org/10.3390/nu7010306 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1422-8599 PURE: 3137852 http://www.scopus.com/inward/record.url?scp=84920545584&partnerID=8YFLogxK https://doi.org/10.3390/nu7010306 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
15 application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
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1817545602481782784 |