Prodrug Systems (II): a perspective of Polymer-based Doxorubicin Prodrug systems towards chemotherapy

Detalhes bibliográficos
Autor(a) principal: Wang, Zhao
Data de Publicação: 2021
Outros Autores: Olim, Filipe, Sun, Jingjing, Neves, Ana Rute, Mendes, Fátima, Tomás, Helena, Sheng, Ruilong
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.13/3821
Resumo: Utilizing biocompatible polymers as platforms to covalently conjugate with chemotherapeutics to construct polymer-based prodrugs and their nano drug delivery systems has attracted great attention in recent years. This perspective reviewed state-of-the-arts for polymer-based doxorubicin prodrugs and the related nanodelivery systems, including: (1) pH-responsive polymer-doxorubicin prodrugs/conjugates; (2) pH/redox dual responsive prodrugs/conjugates; (3) reactive oxygen species/hypoxia-responsive polymer-doxorubicin prodrugs; (4) tumor receptor targeting polymer prodrugs; (5) enzyme-responsive polymer-doxorubicin prodrugs. Finally, possible future perspectives were also stated and discussed.
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spelling Prodrug Systems (II): a perspective of Polymer-based Doxorubicin Prodrug systems towards chemotherapyPolymersDoxorubicinProdrugStimuli-responsiveDrug deliveryNanosystem.Faculdade de Ciências Exatas e da EngenhariaCentro de Química da MadeiraUtilizing biocompatible polymers as platforms to covalently conjugate with chemotherapeutics to construct polymer-based prodrugs and their nano drug delivery systems has attracted great attention in recent years. This perspective reviewed state-of-the-arts for polymer-based doxorubicin prodrugs and the related nanodelivery systems, including: (1) pH-responsive polymer-doxorubicin prodrugs/conjugates; (2) pH/redox dual responsive prodrugs/conjugates; (3) reactive oxygen species/hypoxia-responsive polymer-doxorubicin prodrugs; (4) tumor receptor targeting polymer prodrugs; (5) enzyme-responsive polymer-doxorubicin prodrugs. Finally, possible future perspectives were also stated and discussed.Medicine ResearchDigitUMaWang, ZhaoOlim, FilipeSun, JingjingNeves, Ana RuteMendes, FátimaTomás, HelenaSheng, Ruilong2021-11-16T14:44:17Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.13/3821engWang, Z., Olim, F., Sun, J., Neves, A. R., Mendes, F., Tomás, H., & Sheng, R. Prodrug Systems (II): a perspective of Polymer-based Doxorubicin Prodrug systems towards chemotherapy. Medicine Research. DOI: 10.21127/yaoyimr2020002310.21127/yaoyimr20200023info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-10T06:27:05Zoai:digituma.uma.pt:10400.13/3821Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:07:16.428762Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Prodrug Systems (II): a perspective of Polymer-based Doxorubicin Prodrug systems towards chemotherapy
title Prodrug Systems (II): a perspective of Polymer-based Doxorubicin Prodrug systems towards chemotherapy
spellingShingle Prodrug Systems (II): a perspective of Polymer-based Doxorubicin Prodrug systems towards chemotherapy
Wang, Zhao
Polymers
Doxorubicin
Prodrug
Stimuli-responsive
Drug delivery
Nanosystem
.
Faculdade de Ciências Exatas e da Engenharia
Centro de Química da Madeira
title_short Prodrug Systems (II): a perspective of Polymer-based Doxorubicin Prodrug systems towards chemotherapy
title_full Prodrug Systems (II): a perspective of Polymer-based Doxorubicin Prodrug systems towards chemotherapy
title_fullStr Prodrug Systems (II): a perspective of Polymer-based Doxorubicin Prodrug systems towards chemotherapy
title_full_unstemmed Prodrug Systems (II): a perspective of Polymer-based Doxorubicin Prodrug systems towards chemotherapy
title_sort Prodrug Systems (II): a perspective of Polymer-based Doxorubicin Prodrug systems towards chemotherapy
author Wang, Zhao
author_facet Wang, Zhao
Olim, Filipe
Sun, Jingjing
Neves, Ana Rute
Mendes, Fátima
Tomás, Helena
Sheng, Ruilong
author_role author
author2 Olim, Filipe
Sun, Jingjing
Neves, Ana Rute
Mendes, Fátima
Tomás, Helena
Sheng, Ruilong
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv DigitUMa
dc.contributor.author.fl_str_mv Wang, Zhao
Olim, Filipe
Sun, Jingjing
Neves, Ana Rute
Mendes, Fátima
Tomás, Helena
Sheng, Ruilong
dc.subject.por.fl_str_mv Polymers
Doxorubicin
Prodrug
Stimuli-responsive
Drug delivery
Nanosystem
.
Faculdade de Ciências Exatas e da Engenharia
Centro de Química da Madeira
topic Polymers
Doxorubicin
Prodrug
Stimuli-responsive
Drug delivery
Nanosystem
.
Faculdade de Ciências Exatas e da Engenharia
Centro de Química da Madeira
description Utilizing biocompatible polymers as platforms to covalently conjugate with chemotherapeutics to construct polymer-based prodrugs and their nano drug delivery systems has attracted great attention in recent years. This perspective reviewed state-of-the-arts for polymer-based doxorubicin prodrugs and the related nanodelivery systems, including: (1) pH-responsive polymer-doxorubicin prodrugs/conjugates; (2) pH/redox dual responsive prodrugs/conjugates; (3) reactive oxygen species/hypoxia-responsive polymer-doxorubicin prodrugs; (4) tumor receptor targeting polymer prodrugs; (5) enzyme-responsive polymer-doxorubicin prodrugs. Finally, possible future perspectives were also stated and discussed.
publishDate 2021
dc.date.none.fl_str_mv 2021-11-16T14:44:17Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.13/3821
url http://hdl.handle.net/10400.13/3821
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Wang, Z., Olim, F., Sun, J., Neves, A. R., Mendes, F., Tomás, H., & Sheng, R. Prodrug Systems (II): a perspective of Polymer-based Doxorubicin Prodrug systems towards chemotherapy. Medicine Research. DOI: 10.21127/yaoyimr20200023
10.21127/yaoyimr20200023
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Medicine Research
publisher.none.fl_str_mv Medicine Research
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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