Adhesive and self-healing materials for central nervous system repair
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/84147 |
Resumo: | The central nervous system (CNS) has a limited ability to regenerate after a traumatic injury or a disease due to the low capacity of the neurons to re-grow and the inhibitory environment formed in situ. Current therapies include the use of drugs and rehabilitation, which do not fully restore the CNS functions and only delay the pathology progression. Tissue engineering offers a simple and versatile solution for this problem through the use of bioconstructs that promote nerve tissue repair by bridging cavity spaces. In this approach, the choice of biomaterial is crucial. Herein, we present recent advances in the design and development of adhesive and self-healing materials that support CNS healing. The adhesive materials have the advantage of promoting recovery without the use of needles or sewing, while the self-healing materials have the capacity to restore the tissue integrity without the need for external intervention. These materials can be used alone or in combination with cells and/or bioactive agents to control the inflammation, formation of free radicals, and proteases activity. We discuss the advantages and drawbacks of different systems. The remaining challenges that can bring these materials to clinical reality are also briefly presented. |
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Adhesive and self-healing materials for central nervous system repairBiomimetic adhesivesNeural tissue engineeringRegenerative medicineSpinal cord injuryTissue adhesivesThe central nervous system (CNS) has a limited ability to regenerate after a traumatic injury or a disease due to the low capacity of the neurons to re-grow and the inhibitory environment formed in situ. Current therapies include the use of drugs and rehabilitation, which do not fully restore the CNS functions and only delay the pathology progression. Tissue engineering offers a simple and versatile solution for this problem through the use of bioconstructs that promote nerve tissue repair by bridging cavity spaces. In this approach, the choice of biomaterial is crucial. Herein, we present recent advances in the design and development of adhesive and self-healing materials that support CNS healing. The adhesive materials have the advantage of promoting recovery without the use of needles or sewing, while the self-healing materials have the capacity to restore the tissue integrity without the need for external intervention. These materials can be used alone or in combination with cells and/or bioactive agents to control the inflammation, formation of free radicals, and proteases activity. We discuss the advantages and drawbacks of different systems. The remaining challenges that can bring these materials to clinical reality are also briefly presented.FCT -Fundação para a Ciência e a Tecnologia(PTDC/BTM-MAT/28123/2017)ElsevierUniversidade do MinhoCorreia, C.Reis, R. L.Pashkuleva, I.Alves, N. M.2023-042023-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/84147engCorreia C., Reis R. L., Pashkuleva I., Alves N. M. Adhesive and self-healing materials for central nervous system repair, Biomaterials Advances, pp. in press, doi:10.1016/j.bioadv.2023.213439, 20232772-950810.1016/j.bioadv.2023.213439https://doi.org/10.1016/j.bioadv.2023.213439info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:36:54ZPortal AgregadorONG |
dc.title.none.fl_str_mv |
Adhesive and self-healing materials for central nervous system repair |
title |
Adhesive and self-healing materials for central nervous system repair |
spellingShingle |
Adhesive and self-healing materials for central nervous system repair Correia, C. Biomimetic adhesives Neural tissue engineering Regenerative medicine Spinal cord injury Tissue adhesives |
title_short |
Adhesive and self-healing materials for central nervous system repair |
title_full |
Adhesive and self-healing materials for central nervous system repair |
title_fullStr |
Adhesive and self-healing materials for central nervous system repair |
title_full_unstemmed |
Adhesive and self-healing materials for central nervous system repair |
title_sort |
Adhesive and self-healing materials for central nervous system repair |
author |
Correia, C. |
author_facet |
Correia, C. Reis, R. L. Pashkuleva, I. Alves, N. M. |
author_role |
author |
author2 |
Reis, R. L. Pashkuleva, I. Alves, N. M. |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Correia, C. Reis, R. L. Pashkuleva, I. Alves, N. M. |
dc.subject.por.fl_str_mv |
Biomimetic adhesives Neural tissue engineering Regenerative medicine Spinal cord injury Tissue adhesives |
topic |
Biomimetic adhesives Neural tissue engineering Regenerative medicine Spinal cord injury Tissue adhesives |
description |
The central nervous system (CNS) has a limited ability to regenerate after a traumatic injury or a disease due to the low capacity of the neurons to re-grow and the inhibitory environment formed in situ. Current therapies include the use of drugs and rehabilitation, which do not fully restore the CNS functions and only delay the pathology progression. Tissue engineering offers a simple and versatile solution for this problem through the use of bioconstructs that promote nerve tissue repair by bridging cavity spaces. In this approach, the choice of biomaterial is crucial. Herein, we present recent advances in the design and development of adhesive and self-healing materials that support CNS healing. The adhesive materials have the advantage of promoting recovery without the use of needles or sewing, while the self-healing materials have the capacity to restore the tissue integrity without the need for external intervention. These materials can be used alone or in combination with cells and/or bioactive agents to control the inflammation, formation of free radicals, and proteases activity. We discuss the advantages and drawbacks of different systems. The remaining challenges that can bring these materials to clinical reality are also briefly presented. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-04 2023-04-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/84147 |
url |
https://hdl.handle.net/1822/84147 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Correia C., Reis R. L., Pashkuleva I., Alves N. M. Adhesive and self-healing materials for central nervous system repair, Biomaterials Advances, pp. in press, doi:10.1016/j.bioadv.2023.213439, 2023 2772-9508 10.1016/j.bioadv.2023.213439 https://doi.org/10.1016/j.bioadv.2023.213439 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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1777303800594300928 |