Novel magnetoliposomes containing magnetic nanoparticles covered with gold as nanocarriers for new antitumor tricyclic lactones
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/60769 |
Resumo: | In this work, core/shell magnetic nanoparticles of manganese ferrite/gold were prepared and characterized. In order to develop applications in combined cancer therapy, the prepared nanoparticles were covered with a lipid bilayer (forming magnetoliposomes), these systems being able to transport drugs. TEM and DLS measurements indicated that these systems exhibit sizes around 120 nm. Two new potential antitumor tricyclic lactones were successfully encapsulated in these nanocarriers. The heating capabilities of the developed nanosystems were evaluated upon excitation with a light source. These multifunctional nanosystems have shown promising results for application combined cancer therapy (chemo/phototherapy). |
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Novel magnetoliposomes containing magnetic nanoparticles covered with gold as nanocarriers for new antitumor tricyclic lactonesMagnetic/plasmonic nanoparticlesMagnetoliposomesDrug deliveryAntitumor drugsCancer therapyEngenharia e Tecnologia::NanotecnologiaIn this work, core/shell magnetic nanoparticles of manganese ferrite/gold were prepared and characterized. In order to develop applications in combined cancer therapy, the prepared nanoparticles were covered with a lipid bilayer (forming magnetoliposomes), these systems being able to transport drugs. TEM and DLS measurements indicated that these systems exhibit sizes around 120 nm. Two new potential antitumor tricyclic lactones were successfully encapsulated in these nanocarriers. The heating capabilities of the developed nanosystems were evaluated upon excitation with a light source. These multifunctional nanosystems have shown promising results for application combined cancer therapy (chemo/phototherapy).FCT-Portugal, FEDER, PORTUGAL2020 and COMPETE2020 for funding under Project PTDC/QUI-QFI/28020/2017 (POCI-01-0145-FEDER-028020) and Strategic funding of CF-UM-UP (UID/FIS/04650/2019) and CQUM (UID/QUI/00686/2019). J.M.R. PhD grant is financed by FCT, POCH and ESFRICT 2019. Organizing CommitteeUniversidade do MinhoRio, Irina S. R.Rodrigues, Juliana M.Rodrigues, Ana Rita OliveiraCoutinho, Paulo J. G.Castanheira, Elisabete M. S.Queiroz, Maria João R. P.20192019-01-01T00:00:00Zconference objectinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/1822/60769enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-11T07:32:11Zoai:repositorium.sdum.uminho.pt:1822/60769Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-11T07:32:11Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Novel magnetoliposomes containing magnetic nanoparticles covered with gold as nanocarriers for new antitumor tricyclic lactones |
title |
Novel magnetoliposomes containing magnetic nanoparticles covered with gold as nanocarriers for new antitumor tricyclic lactones |
spellingShingle |
Novel magnetoliposomes containing magnetic nanoparticles covered with gold as nanocarriers for new antitumor tricyclic lactones Rio, Irina S. R. Magnetic/plasmonic nanoparticles Magnetoliposomes Drug delivery Antitumor drugs Cancer therapy Engenharia e Tecnologia::Nanotecnologia |
title_short |
Novel magnetoliposomes containing magnetic nanoparticles covered with gold as nanocarriers for new antitumor tricyclic lactones |
title_full |
Novel magnetoliposomes containing magnetic nanoparticles covered with gold as nanocarriers for new antitumor tricyclic lactones |
title_fullStr |
Novel magnetoliposomes containing magnetic nanoparticles covered with gold as nanocarriers for new antitumor tricyclic lactones |
title_full_unstemmed |
Novel magnetoliposomes containing magnetic nanoparticles covered with gold as nanocarriers for new antitumor tricyclic lactones |
title_sort |
Novel magnetoliposomes containing magnetic nanoparticles covered with gold as nanocarriers for new antitumor tricyclic lactones |
author |
Rio, Irina S. R. |
author_facet |
Rio, Irina S. R. Rodrigues, Juliana M. Rodrigues, Ana Rita Oliveira Coutinho, Paulo J. G. Castanheira, Elisabete M. S. Queiroz, Maria João R. P. |
author_role |
author |
author2 |
Rodrigues, Juliana M. Rodrigues, Ana Rita Oliveira Coutinho, Paulo J. G. Castanheira, Elisabete M. S. Queiroz, Maria João R. P. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Rio, Irina S. R. Rodrigues, Juliana M. Rodrigues, Ana Rita Oliveira Coutinho, Paulo J. G. Castanheira, Elisabete M. S. Queiroz, Maria João R. P. |
dc.subject.por.fl_str_mv |
Magnetic/plasmonic nanoparticles Magnetoliposomes Drug delivery Antitumor drugs Cancer therapy Engenharia e Tecnologia::Nanotecnologia |
topic |
Magnetic/plasmonic nanoparticles Magnetoliposomes Drug delivery Antitumor drugs Cancer therapy Engenharia e Tecnologia::Nanotecnologia |
description |
In this work, core/shell magnetic nanoparticles of manganese ferrite/gold were prepared and characterized. In order to develop applications in combined cancer therapy, the prepared nanoparticles were covered with a lipid bilayer (forming magnetoliposomes), these systems being able to transport drugs. TEM and DLS measurements indicated that these systems exhibit sizes around 120 nm. Two new potential antitumor tricyclic lactones were successfully encapsulated in these nanocarriers. The heating capabilities of the developed nanosystems were evaluated upon excitation with a light source. These multifunctional nanosystems have shown promising results for application combined cancer therapy (chemo/phototherapy). |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019 2019-01-01T00:00:00Z |
dc.type.driver.fl_str_mv |
conference object |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/60769 |
url |
http://hdl.handle.net/1822/60769 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
RICT 2019. Organizing Committee |
publisher.none.fl_str_mv |
RICT 2019. Organizing Committee |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
_version_ |
1817545351500922880 |