From plant survival under severe stress to anti-viral human defense - a perspective that calls for common efforts
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10174/32111 |
Resumo: | Reprogramming of primary virus-infected cells is the critical step that turns viral attacks harmful to humans by initiating super-spreading at cell, organism and population levels. To develop early anti-viral therapies and proactive administration, it is important to understand the very first steps of this process. Plant somatic embryogenesis (SE) is the earliest and most studied model for de novo programming upon severe stress that, in contrast to virus attacks, promotes individual cell and organism survival. We argued that transcript level profiles of target genes established from in vitro SE induction as reference compared to virus-induced profiles can identify differential virus traits that link to harmful reprogramming. To validate this hypothesis, we selected a standard set of genes named ‘ReprogVirus’. This approach was recently applied and published. It resulted in identifying ‘CoV-MAC-TED’, a complex trait that is promising to support combating SARS-CoV-2-induced cell reprogramming in primary infected nose and mouth cells. In this perspective, we aim to explain the rationale of our scientific approach. We are highlighting relevant background knowledge on SE, emphasize the role of alternative oxidase in plant reprogramming and resilience as a learning tool for designing human virus-defense strategies and, present the list of selected genes. As an outlook, we announce wider data collection in a ‘ReprogVirus Platform’ to support anti-viral strategy design through common efforts. |
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From plant survival under severe stress to anti-viral human defense - a perspective that calls for common effortsReprogramming of primary virus-infected cells is the critical step that turns viral attacks harmful to humans by initiating super-spreading at cell, organism and population levels. To develop early anti-viral therapies and proactive administration, it is important to understand the very first steps of this process. Plant somatic embryogenesis (SE) is the earliest and most studied model for de novo programming upon severe stress that, in contrast to virus attacks, promotes individual cell and organism survival. We argued that transcript level profiles of target genes established from in vitro SE induction as reference compared to virus-induced profiles can identify differential virus traits that link to harmful reprogramming. To validate this hypothesis, we selected a standard set of genes named ‘ReprogVirus’. This approach was recently applied and published. It resulted in identifying ‘CoV-MAC-TED’, a complex trait that is promising to support combating SARS-CoV-2-induced cell reprogramming in primary infected nose and mouth cells. In this perspective, we aim to explain the rationale of our scientific approach. We are highlighting relevant background knowledge on SE, emphasize the role of alternative oxidase in plant reprogramming and resilience as a learning tool for designing human virus-defense strategies and, present the list of selected genes. As an outlook, we announce wider data collection in a ‘ReprogVirus Platform’ to support anti-viral strategy design through common efforts.Frontiers Media2022-05-30T10:48:28Z2022-05-302021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10174/32111http://hdl.handle.net/10174/32111engBirgit Arnholdt-Schmitt, Gunasekaran Mohanapriya, Revuru Bharadwaj, Carlos Noceda, Elisete Santos Macedo, Ramalingam Sathishkumar, Kapuganti Jagadis Gupta, Debabrata Sircar, Sarma Rajeev Kumar, Shivani Srivastava, Alok Adholeya, KarineLeitão Lima Thiers, Shahid Aziz, Isabel Velada, Manuela Oliveira, Paulo Quaresma, Arvind Achra, Nidhi Gupta, Ashwani Kumar, and José Hélio Costa. From plant survival under severe stress to anti-viral human defense - a perspective that calls for common efforts. Frontiers in Immunology, 12:2066, 2021.https://www.frontiersin.org/articles/10.3389/fimmu.2021.673723/fullndndndndndndndndndndndndndndndpq@uevora.ptndndndnd370Arnholdt-Schmitt, BirgitMohanapriya, GunasekaranBharadwaj, RevuruNoceda, CarlosMacedo, EliseteSathishkumar, RamalingamGupta, KapugantiSircar, DebabrataKumar, SarmaSrivastava, ShivaniAdholeya, AlokThiers, KarineAziz, ShahidVelada, IsabelOliveira, ManuelaQuaresma, PauloAchra, ArvindGupta, NidhiKumar, AshwaniHélio Costa, Joséinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-03T19:32:29Zoai:dspace.uevora.pt:10174/32111Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:21:12.417791Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
From plant survival under severe stress to anti-viral human defense - a perspective that calls for common efforts |
title |
From plant survival under severe stress to anti-viral human defense - a perspective that calls for common efforts |
spellingShingle |
From plant survival under severe stress to anti-viral human defense - a perspective that calls for common efforts Arnholdt-Schmitt, Birgit |
title_short |
From plant survival under severe stress to anti-viral human defense - a perspective that calls for common efforts |
title_full |
From plant survival under severe stress to anti-viral human defense - a perspective that calls for common efforts |
title_fullStr |
From plant survival under severe stress to anti-viral human defense - a perspective that calls for common efforts |
title_full_unstemmed |
From plant survival under severe stress to anti-viral human defense - a perspective that calls for common efforts |
title_sort |
From plant survival under severe stress to anti-viral human defense - a perspective that calls for common efforts |
author |
Arnholdt-Schmitt, Birgit |
author_facet |
Arnholdt-Schmitt, Birgit Mohanapriya, Gunasekaran Bharadwaj, Revuru Noceda, Carlos Macedo, Elisete Sathishkumar, Ramalingam Gupta, Kapuganti Sircar, Debabrata Kumar, Sarma Srivastava, Shivani Adholeya, Alok Thiers, Karine Aziz, Shahid Velada, Isabel Oliveira, Manuela Quaresma, Paulo Achra, Arvind Gupta, Nidhi Kumar, Ashwani Hélio Costa, José |
author_role |
author |
author2 |
Mohanapriya, Gunasekaran Bharadwaj, Revuru Noceda, Carlos Macedo, Elisete Sathishkumar, Ramalingam Gupta, Kapuganti Sircar, Debabrata Kumar, Sarma Srivastava, Shivani Adholeya, Alok Thiers, Karine Aziz, Shahid Velada, Isabel Oliveira, Manuela Quaresma, Paulo Achra, Arvind Gupta, Nidhi Kumar, Ashwani Hélio Costa, José |
author2_role |
author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Arnholdt-Schmitt, Birgit Mohanapriya, Gunasekaran Bharadwaj, Revuru Noceda, Carlos Macedo, Elisete Sathishkumar, Ramalingam Gupta, Kapuganti Sircar, Debabrata Kumar, Sarma Srivastava, Shivani Adholeya, Alok Thiers, Karine Aziz, Shahid Velada, Isabel Oliveira, Manuela Quaresma, Paulo Achra, Arvind Gupta, Nidhi Kumar, Ashwani Hélio Costa, José |
description |
Reprogramming of primary virus-infected cells is the critical step that turns viral attacks harmful to humans by initiating super-spreading at cell, organism and population levels. To develop early anti-viral therapies and proactive administration, it is important to understand the very first steps of this process. Plant somatic embryogenesis (SE) is the earliest and most studied model for de novo programming upon severe stress that, in contrast to virus attacks, promotes individual cell and organism survival. We argued that transcript level profiles of target genes established from in vitro SE induction as reference compared to virus-induced profiles can identify differential virus traits that link to harmful reprogramming. To validate this hypothesis, we selected a standard set of genes named ‘ReprogVirus’. This approach was recently applied and published. It resulted in identifying ‘CoV-MAC-TED’, a complex trait that is promising to support combating SARS-CoV-2-induced cell reprogramming in primary infected nose and mouth cells. In this perspective, we aim to explain the rationale of our scientific approach. We are highlighting relevant background knowledge on SE, emphasize the role of alternative oxidase in plant reprogramming and resilience as a learning tool for designing human virus-defense strategies and, present the list of selected genes. As an outlook, we announce wider data collection in a ‘ReprogVirus Platform’ to support anti-viral strategy design through common efforts. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01T00:00:00Z 2022-05-30T10:48:28Z 2022-05-30 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10174/32111 http://hdl.handle.net/10174/32111 |
url |
http://hdl.handle.net/10174/32111 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Birgit Arnholdt-Schmitt, Gunasekaran Mohanapriya, Revuru Bharadwaj, Carlos Noceda, Elisete Santos Macedo, Ramalingam Sathishkumar, Kapuganti Jagadis Gupta, Debabrata Sircar, Sarma Rajeev Kumar, Shivani Srivastava, Alok Adholeya, KarineLeitão Lima Thiers, Shahid Aziz, Isabel Velada, Manuela Oliveira, Paulo Quaresma, Arvind Achra, Nidhi Gupta, Ashwani Kumar, and José Hélio Costa. From plant survival under severe stress to anti-viral human defense - a perspective that calls for common efforts. Frontiers in Immunology, 12:2066, 2021. https://www.frontiersin.org/articles/10.3389/fimmu.2021.673723/full nd nd nd nd nd nd nd nd nd nd nd nd nd nd nd pq@uevora.pt nd nd nd nd 370 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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