Antioxidant extracts of three russula genus species express diverse biological activity

Detalhes bibliográficos
Autor(a) principal: Kostić, Marina
Data de Publicação: 2018
Outros Autores: Ivanov, Marija, Fernandes, Ângela, Pinela, José, Calhelha, Ricardo C., Glamočlija, Jasmina, Barros, Lillian, Ferreira, Isabel C.F.R., Soković, Marina, Ćirić, Ana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10198/23386
Resumo: This study explored the biological properties of three wild growing Russula species (R. integra, R. rosea, R. nigricans) from Serbia. Compositional features and antioxidant, antibacterial, antibiofilm, and cytotoxic activities were analyzed. The studied mushroom species were identified as being rich sources of carbohydrates and of low caloric value. Mannitol was the most abundant free sugar and quinic and malic acids the major organic acids detected. The four tocopherol isoforms were found, and polyunsaturated fatty acids were the predominant fat constituents. Regarding phenolic compounds, P-hydroxybenzoic and cinnamic acids were identified in the prepared methanolic and ethanolic extracts, which displayed antioxidant activity through the inhibition of thiobarbituric acid reactive substances (TBARS) formation and oxidative hemolysis; the highest activity was attributed to the R. nigricans ethanolic extract. This is the first report on the antibacterial and antibiofilm potential of the studied species, with the most promising activity observed towards Streptococcus spp. (0.20–0.78 mg/mL as the minimal inhibitory concentration, MIC). The most promising cytotoxic effect was caused by the R. integra methanolic extract on non-small cell lung cancer cells (NCI-H460). Therefore, due to the observed in vitro bioactive properties, the studied mushrooms arise as a source of functional ingredients with potential to be used in novel nutraceutical and drug formulations, which can be used in the treatment of various diseases and health conditions.
id RCAP_0fddbec2069c8810c0727f5cc6b4a47c
oai_identifier_str oai:bibliotecadigital.ipb.pt:10198/23386
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Antioxidant extracts of three russula genus species express diverse biological activityAntibacterial agentsAntibiofilm activityAntioxidant activityCytotoxicityFunctional ingredientsRussula integraRussula nigricansRussula roseaThis study explored the biological properties of three wild growing Russula species (R. integra, R. rosea, R. nigricans) from Serbia. Compositional features and antioxidant, antibacterial, antibiofilm, and cytotoxic activities were analyzed. The studied mushroom species were identified as being rich sources of carbohydrates and of low caloric value. Mannitol was the most abundant free sugar and quinic and malic acids the major organic acids detected. The four tocopherol isoforms were found, and polyunsaturated fatty acids were the predominant fat constituents. Regarding phenolic compounds, P-hydroxybenzoic and cinnamic acids were identified in the prepared methanolic and ethanolic extracts, which displayed antioxidant activity through the inhibition of thiobarbituric acid reactive substances (TBARS) formation and oxidative hemolysis; the highest activity was attributed to the R. nigricans ethanolic extract. This is the first report on the antibacterial and antibiofilm potential of the studied species, with the most promising activity observed towards Streptococcus spp. (0.20–0.78 mg/mL as the minimal inhibitory concentration, MIC). The most promising cytotoxic effect was caused by the R. integra methanolic extract on non-small cell lung cancer cells (NCI-H460). Therefore, due to the observed in vitro bioactive properties, the studied mushrooms arise as a source of functional ingredients with potential to be used in novel nutraceutical and drug formulations, which can be used in the treatment of various diseases and health conditions.The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES to CIMO (UIDB/00690/2020). L. Barros, A. Fernandes, J. Pinela and R. Calhelha also thank the national funding by FCT–Foundation for Science and Technology, P.I. The authors are grateful to FEDER-Interreg España-Portugal programme for financial support through the project 0377_Iberphenol_6_E; and to the Ministry of Education, Science and Technological Development of Republic of Serbia (451-03-68/2020-14/200007).Biblioteca Digital do IPBKostić, MarinaIvanov, MarijaFernandes, ÂngelaPinela, JoséCalhelha, Ricardo C.Glamočlija, JasminaBarros, LillianFerreira, Isabel C.F.R.Soković, MarinaĆirić, Ana2018-01-19T10:00:00Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/23386engKostić, Marina; Ivanov, Marija; Fernandes, Ângela; Pinela, José; Calhelha, Ricardo C.; Glamočlija, Jasmina; Barros, Lillian; Ferreira, Isabel C.F.R.; Soković, Marina; Ćirić, Ana (2020). Antioxidant extracts of three russula genus species express diverse biological activity. Molecules. ISSN 1420-3049. 25:18, p. 1-1410.3390/molecules25184336info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:52:17Zoai:bibliotecadigital.ipb.pt:10198/23386Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:14:23.376339Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Antioxidant extracts of three russula genus species express diverse biological activity
title Antioxidant extracts of three russula genus species express diverse biological activity
spellingShingle Antioxidant extracts of three russula genus species express diverse biological activity
Kostić, Marina
Antibacterial agents
Antibiofilm activity
Antioxidant activity
Cytotoxicity
Functional ingredients
Russula integra
Russula nigricans
Russula rosea
title_short Antioxidant extracts of three russula genus species express diverse biological activity
title_full Antioxidant extracts of three russula genus species express diverse biological activity
title_fullStr Antioxidant extracts of three russula genus species express diverse biological activity
title_full_unstemmed Antioxidant extracts of three russula genus species express diverse biological activity
title_sort Antioxidant extracts of three russula genus species express diverse biological activity
author Kostić, Marina
author_facet Kostić, Marina
Ivanov, Marija
Fernandes, Ângela
Pinela, José
Calhelha, Ricardo C.
Glamočlija, Jasmina
Barros, Lillian
Ferreira, Isabel C.F.R.
Soković, Marina
Ćirić, Ana
author_role author
author2 Ivanov, Marija
Fernandes, Ângela
Pinela, José
Calhelha, Ricardo C.
Glamočlija, Jasmina
Barros, Lillian
Ferreira, Isabel C.F.R.
Soković, Marina
Ćirić, Ana
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Biblioteca Digital do IPB
dc.contributor.author.fl_str_mv Kostić, Marina
Ivanov, Marija
Fernandes, Ângela
Pinela, José
Calhelha, Ricardo C.
Glamočlija, Jasmina
Barros, Lillian
Ferreira, Isabel C.F.R.
Soković, Marina
Ćirić, Ana
dc.subject.por.fl_str_mv Antibacterial agents
Antibiofilm activity
Antioxidant activity
Cytotoxicity
Functional ingredients
Russula integra
Russula nigricans
Russula rosea
topic Antibacterial agents
Antibiofilm activity
Antioxidant activity
Cytotoxicity
Functional ingredients
Russula integra
Russula nigricans
Russula rosea
description This study explored the biological properties of three wild growing Russula species (R. integra, R. rosea, R. nigricans) from Serbia. Compositional features and antioxidant, antibacterial, antibiofilm, and cytotoxic activities were analyzed. The studied mushroom species were identified as being rich sources of carbohydrates and of low caloric value. Mannitol was the most abundant free sugar and quinic and malic acids the major organic acids detected. The four tocopherol isoforms were found, and polyunsaturated fatty acids were the predominant fat constituents. Regarding phenolic compounds, P-hydroxybenzoic and cinnamic acids were identified in the prepared methanolic and ethanolic extracts, which displayed antioxidant activity through the inhibition of thiobarbituric acid reactive substances (TBARS) formation and oxidative hemolysis; the highest activity was attributed to the R. nigricans ethanolic extract. This is the first report on the antibacterial and antibiofilm potential of the studied species, with the most promising activity observed towards Streptococcus spp. (0.20–0.78 mg/mL as the minimal inhibitory concentration, MIC). The most promising cytotoxic effect was caused by the R. integra methanolic extract on non-small cell lung cancer cells (NCI-H460). Therefore, due to the observed in vitro bioactive properties, the studied mushrooms arise as a source of functional ingredients with potential to be used in novel nutraceutical and drug formulations, which can be used in the treatment of various diseases and health conditions.
publishDate 2018
dc.date.none.fl_str_mv 2018-01-19T10:00:00Z
2020
2020-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10198/23386
url http://hdl.handle.net/10198/23386
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Kostić, Marina; Ivanov, Marija; Fernandes, Ângela; Pinela, José; Calhelha, Ricardo C.; Glamočlija, Jasmina; Barros, Lillian; Ferreira, Isabel C.F.R.; Soković, Marina; Ćirić, Ana (2020). Antioxidant extracts of three russula genus species express diverse biological activity. Molecules. ISSN 1420-3049. 25:18, p. 1-14
10.3390/molecules25184336
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799135423255019520