Antioxidant extracts of three russula genus species express diverse biological activity
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10198/23386 |
Resumo: | This study explored the biological properties of three wild growing Russula species (R. integra, R. rosea, R. nigricans) from Serbia. Compositional features and antioxidant, antibacterial, antibiofilm, and cytotoxic activities were analyzed. The studied mushroom species were identified as being rich sources of carbohydrates and of low caloric value. Mannitol was the most abundant free sugar and quinic and malic acids the major organic acids detected. The four tocopherol isoforms were found, and polyunsaturated fatty acids were the predominant fat constituents. Regarding phenolic compounds, P-hydroxybenzoic and cinnamic acids were identified in the prepared methanolic and ethanolic extracts, which displayed antioxidant activity through the inhibition of thiobarbituric acid reactive substances (TBARS) formation and oxidative hemolysis; the highest activity was attributed to the R. nigricans ethanolic extract. This is the first report on the antibacterial and antibiofilm potential of the studied species, with the most promising activity observed towards Streptococcus spp. (0.20–0.78 mg/mL as the minimal inhibitory concentration, MIC). The most promising cytotoxic effect was caused by the R. integra methanolic extract on non-small cell lung cancer cells (NCI-H460). Therefore, due to the observed in vitro bioactive properties, the studied mushrooms arise as a source of functional ingredients with potential to be used in novel nutraceutical and drug formulations, which can be used in the treatment of various diseases and health conditions. |
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Antioxidant extracts of three russula genus species express diverse biological activityAntibacterial agentsAntibiofilm activityAntioxidant activityCytotoxicityFunctional ingredientsRussula integraRussula nigricansRussula roseaThis study explored the biological properties of three wild growing Russula species (R. integra, R. rosea, R. nigricans) from Serbia. Compositional features and antioxidant, antibacterial, antibiofilm, and cytotoxic activities were analyzed. The studied mushroom species were identified as being rich sources of carbohydrates and of low caloric value. Mannitol was the most abundant free sugar and quinic and malic acids the major organic acids detected. The four tocopherol isoforms were found, and polyunsaturated fatty acids were the predominant fat constituents. Regarding phenolic compounds, P-hydroxybenzoic and cinnamic acids were identified in the prepared methanolic and ethanolic extracts, which displayed antioxidant activity through the inhibition of thiobarbituric acid reactive substances (TBARS) formation and oxidative hemolysis; the highest activity was attributed to the R. nigricans ethanolic extract. This is the first report on the antibacterial and antibiofilm potential of the studied species, with the most promising activity observed towards Streptococcus spp. (0.20–0.78 mg/mL as the minimal inhibitory concentration, MIC). The most promising cytotoxic effect was caused by the R. integra methanolic extract on non-small cell lung cancer cells (NCI-H460). Therefore, due to the observed in vitro bioactive properties, the studied mushrooms arise as a source of functional ingredients with potential to be used in novel nutraceutical and drug formulations, which can be used in the treatment of various diseases and health conditions.The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES to CIMO (UIDB/00690/2020). L. Barros, A. Fernandes, J. Pinela and R. Calhelha also thank the national funding by FCT–Foundation for Science and Technology, P.I. The authors are grateful to FEDER-Interreg España-Portugal programme for financial support through the project 0377_Iberphenol_6_E; and to the Ministry of Education, Science and Technological Development of Republic of Serbia (451-03-68/2020-14/200007).Biblioteca Digital do IPBKostić, MarinaIvanov, MarijaFernandes, ÂngelaPinela, JoséCalhelha, Ricardo C.Glamočlija, JasminaBarros, LillianFerreira, Isabel C.F.R.Soković, MarinaĆirić, Ana2018-01-19T10:00:00Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/23386engKostić, Marina; Ivanov, Marija; Fernandes, Ângela; Pinela, José; Calhelha, Ricardo C.; Glamočlija, Jasmina; Barros, Lillian; Ferreira, Isabel C.F.R.; Soković, Marina; Ćirić, Ana (2020). Antioxidant extracts of three russula genus species express diverse biological activity. Molecules. ISSN 1420-3049. 25:18, p. 1-1410.3390/molecules25184336info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:52:17Zoai:bibliotecadigital.ipb.pt:10198/23386Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:14:23.376339Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Antioxidant extracts of three russula genus species express diverse biological activity |
title |
Antioxidant extracts of three russula genus species express diverse biological activity |
spellingShingle |
Antioxidant extracts of three russula genus species express diverse biological activity Kostić, Marina Antibacterial agents Antibiofilm activity Antioxidant activity Cytotoxicity Functional ingredients Russula integra Russula nigricans Russula rosea |
title_short |
Antioxidant extracts of three russula genus species express diverse biological activity |
title_full |
Antioxidant extracts of three russula genus species express diverse biological activity |
title_fullStr |
Antioxidant extracts of three russula genus species express diverse biological activity |
title_full_unstemmed |
Antioxidant extracts of three russula genus species express diverse biological activity |
title_sort |
Antioxidant extracts of three russula genus species express diverse biological activity |
author |
Kostić, Marina |
author_facet |
Kostić, Marina Ivanov, Marija Fernandes, Ângela Pinela, José Calhelha, Ricardo C. Glamočlija, Jasmina Barros, Lillian Ferreira, Isabel C.F.R. Soković, Marina Ćirić, Ana |
author_role |
author |
author2 |
Ivanov, Marija Fernandes, Ângela Pinela, José Calhelha, Ricardo C. Glamočlija, Jasmina Barros, Lillian Ferreira, Isabel C.F.R. Soković, Marina Ćirić, Ana |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Biblioteca Digital do IPB |
dc.contributor.author.fl_str_mv |
Kostić, Marina Ivanov, Marija Fernandes, Ângela Pinela, José Calhelha, Ricardo C. Glamočlija, Jasmina Barros, Lillian Ferreira, Isabel C.F.R. Soković, Marina Ćirić, Ana |
dc.subject.por.fl_str_mv |
Antibacterial agents Antibiofilm activity Antioxidant activity Cytotoxicity Functional ingredients Russula integra Russula nigricans Russula rosea |
topic |
Antibacterial agents Antibiofilm activity Antioxidant activity Cytotoxicity Functional ingredients Russula integra Russula nigricans Russula rosea |
description |
This study explored the biological properties of three wild growing Russula species (R. integra, R. rosea, R. nigricans) from Serbia. Compositional features and antioxidant, antibacterial, antibiofilm, and cytotoxic activities were analyzed. The studied mushroom species were identified as being rich sources of carbohydrates and of low caloric value. Mannitol was the most abundant free sugar and quinic and malic acids the major organic acids detected. The four tocopherol isoforms were found, and polyunsaturated fatty acids were the predominant fat constituents. Regarding phenolic compounds, P-hydroxybenzoic and cinnamic acids were identified in the prepared methanolic and ethanolic extracts, which displayed antioxidant activity through the inhibition of thiobarbituric acid reactive substances (TBARS) formation and oxidative hemolysis; the highest activity was attributed to the R. nigricans ethanolic extract. This is the first report on the antibacterial and antibiofilm potential of the studied species, with the most promising activity observed towards Streptococcus spp. (0.20–0.78 mg/mL as the minimal inhibitory concentration, MIC). The most promising cytotoxic effect was caused by the R. integra methanolic extract on non-small cell lung cancer cells (NCI-H460). Therefore, due to the observed in vitro bioactive properties, the studied mushrooms arise as a source of functional ingredients with potential to be used in novel nutraceutical and drug formulations, which can be used in the treatment of various diseases and health conditions. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-19T10:00:00Z 2020 2020-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10198/23386 |
url |
http://hdl.handle.net/10198/23386 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Kostić, Marina; Ivanov, Marija; Fernandes, Ângela; Pinela, José; Calhelha, Ricardo C.; Glamočlija, Jasmina; Barros, Lillian; Ferreira, Isabel C.F.R.; Soković, Marina; Ćirić, Ana (2020). Antioxidant extracts of three russula genus species express diverse biological activity. Molecules. ISSN 1420-3049. 25:18, p. 1-14 10.3390/molecules25184336 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799135423255019520 |