Firefighters' exposure biomonitoring: Impact of firefighting activities on levels of urinary monohydroxyl metabolites
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/4071 |
Resumo: | The concentrations of six urinary monohydroxyl metabolites (OH-PAHs) of polycyclic aromatic hydrocarbons, namely 1-hydroxynaphthalene, 1-hydroxyacenaphthene, 2-hydroxyfluorene, 1-hydroxyphenanthrene, 1-hydroxypyrene (1OHPy), and 3-hydroxybenzo[a]pyrene, were assessed in the post-shift urine of wildland firefighters involved in fire combat activities at six Portuguese fire corporations, and compared with those of non-exposed subjects. Overall, median levels of urinary individual and total OH-PAHs (ΣOH-PAHs) suggest an increased exposure to polycyclic aromatic hydrocarbons during firefighting activities with ΣOH-PAH levels in exposed firefighters 1.7-35 times higher than in non-exposed ones. Urinary 1-hydroxynaphthalene and/or 1-hydroxyacenapthene were the predominant compounds, representing 63-98% of ΣOH-PAHs, followed by 2-hydroxyfluorene (1-17%), 1-hydroxyphenanthrene (1-13%), and 1OHPy (0.3-10%). A similar profile was observed when gender discrimination was considered. Participation in fire combat activities promoted an increase of the distribution percentage of 1-hydroxynaphthalene and 1-hydroxyacenaphthene, while contributions of 1-hydroxyphenanthrene and 1OHPy decreased. The detected urinary 1OHPy concentrations (1.73×10(-2) to 0.152μmol/mol creatinine in exposed subjects versus 1.21×10(-2) to 5.44×10(-2)μmol/mol creatinine in non-exposed individuals) were lower than the benchmark level (0.5μmol/mol creatinine) proposed by the American Conference of Governmental Industrial Hygienists. This compound, considered the biomarker of exposure to PAHs, was the less abundant one from the six analyzed biomarkers. Thus the inclusion of other metabolites, in addition to 1OHPy, in future studies is suggested to better estimate firefighters' occupational exposure to PAHs. Moreover, strong to moderate Spearman correlations were observed between individual compounds and ΣOH-PAHs corroborating the prevalence of an emission source. |
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Firefighters' exposure biomonitoring: Impact of firefighting activities on levels of urinary monohydroxyl metabolitesWildland FirefightersPolycyclic Aromatic HydrocarbonsOccupational ExposureBiomarkers of ExposureUrinary Monohydroxyl MetabolitesAr e Saúde OcupacionalThe concentrations of six urinary monohydroxyl metabolites (OH-PAHs) of polycyclic aromatic hydrocarbons, namely 1-hydroxynaphthalene, 1-hydroxyacenaphthene, 2-hydroxyfluorene, 1-hydroxyphenanthrene, 1-hydroxypyrene (1OHPy), and 3-hydroxybenzo[a]pyrene, were assessed in the post-shift urine of wildland firefighters involved in fire combat activities at six Portuguese fire corporations, and compared with those of non-exposed subjects. Overall, median levels of urinary individual and total OH-PAHs (ΣOH-PAHs) suggest an increased exposure to polycyclic aromatic hydrocarbons during firefighting activities with ΣOH-PAH levels in exposed firefighters 1.7-35 times higher than in non-exposed ones. Urinary 1-hydroxynaphthalene and/or 1-hydroxyacenapthene were the predominant compounds, representing 63-98% of ΣOH-PAHs, followed by 2-hydroxyfluorene (1-17%), 1-hydroxyphenanthrene (1-13%), and 1OHPy (0.3-10%). A similar profile was observed when gender discrimination was considered. Participation in fire combat activities promoted an increase of the distribution percentage of 1-hydroxynaphthalene and 1-hydroxyacenaphthene, while contributions of 1-hydroxyphenanthrene and 1OHPy decreased. The detected urinary 1OHPy concentrations (1.73×10(-2) to 0.152μmol/mol creatinine in exposed subjects versus 1.21×10(-2) to 5.44×10(-2)μmol/mol creatinine in non-exposed individuals) were lower than the benchmark level (0.5μmol/mol creatinine) proposed by the American Conference of Governmental Industrial Hygienists. This compound, considered the biomarker of exposure to PAHs, was the less abundant one from the six analyzed biomarkers. Thus the inclusion of other metabolites, in addition to 1OHPy, in future studies is suggested to better estimate firefighters' occupational exposure to PAHs. Moreover, strong to moderate Spearman correlations were observed between individual compounds and ΣOH-PAHs corroborating the prevalence of an emission source.This study was financed by European (FEDER funds through COMPETE) and National (Fundação para a Ciência e Tecnologia project UID/QUI/50006/2013) funds and in the scope of the P2020 Partnership Agreement Project POCI-01-0145-FEDER-006939 (Laboratory for Process Engineering, Environment, Biotechnology and Energy—LEPABE) funded by FEDER funds through COMPETE2020—Programa Operacional Competitividade e Internacionalização (POCI). Authors are also grateful to for the financial support through the fellowships (SFRH/BD/80113/2011 and SFRH/BPD/65722/2009).Elsevier/Urban and FischerRepositório Científico do Instituto Nacional de SaúdeOliveira, MartaSlezakova, KlaraAlves, Maria JoséFernandes, AdíliaTeixeira, João PauloDelerue-Matos, CristinaPereira, Maria do CarmoMorais, Simone2020-07-16T00:30:11Z2016-07-152016-07-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/4071engInt J Hyg Environ Health. 2016 Nov;219(8):857-866. doi: 10.1016/j.ijheh.2016.07.011. Epub 2016 Jul 15.1438-463910.1016/j.ijheh.2016.07.011info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:40:05Zoai:repositorio.insa.pt:10400.18/4071Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:38:49.171957Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Firefighters' exposure biomonitoring: Impact of firefighting activities on levels of urinary monohydroxyl metabolites |
title |
Firefighters' exposure biomonitoring: Impact of firefighting activities on levels of urinary monohydroxyl metabolites |
spellingShingle |
Firefighters' exposure biomonitoring: Impact of firefighting activities on levels of urinary monohydroxyl metabolites Oliveira, Marta Wildland Firefighters Polycyclic Aromatic Hydrocarbons Occupational Exposure Biomarkers of Exposure Urinary Monohydroxyl Metabolites Ar e Saúde Ocupacional |
title_short |
Firefighters' exposure biomonitoring: Impact of firefighting activities on levels of urinary monohydroxyl metabolites |
title_full |
Firefighters' exposure biomonitoring: Impact of firefighting activities on levels of urinary monohydroxyl metabolites |
title_fullStr |
Firefighters' exposure biomonitoring: Impact of firefighting activities on levels of urinary monohydroxyl metabolites |
title_full_unstemmed |
Firefighters' exposure biomonitoring: Impact of firefighting activities on levels of urinary monohydroxyl metabolites |
title_sort |
Firefighters' exposure biomonitoring: Impact of firefighting activities on levels of urinary monohydroxyl metabolites |
author |
Oliveira, Marta |
author_facet |
Oliveira, Marta Slezakova, Klara Alves, Maria José Fernandes, Adília Teixeira, João Paulo Delerue-Matos, Cristina Pereira, Maria do Carmo Morais, Simone |
author_role |
author |
author2 |
Slezakova, Klara Alves, Maria José Fernandes, Adília Teixeira, João Paulo Delerue-Matos, Cristina Pereira, Maria do Carmo Morais, Simone |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Oliveira, Marta Slezakova, Klara Alves, Maria José Fernandes, Adília Teixeira, João Paulo Delerue-Matos, Cristina Pereira, Maria do Carmo Morais, Simone |
dc.subject.por.fl_str_mv |
Wildland Firefighters Polycyclic Aromatic Hydrocarbons Occupational Exposure Biomarkers of Exposure Urinary Monohydroxyl Metabolites Ar e Saúde Ocupacional |
topic |
Wildland Firefighters Polycyclic Aromatic Hydrocarbons Occupational Exposure Biomarkers of Exposure Urinary Monohydroxyl Metabolites Ar e Saúde Ocupacional |
description |
The concentrations of six urinary monohydroxyl metabolites (OH-PAHs) of polycyclic aromatic hydrocarbons, namely 1-hydroxynaphthalene, 1-hydroxyacenaphthene, 2-hydroxyfluorene, 1-hydroxyphenanthrene, 1-hydroxypyrene (1OHPy), and 3-hydroxybenzo[a]pyrene, were assessed in the post-shift urine of wildland firefighters involved in fire combat activities at six Portuguese fire corporations, and compared with those of non-exposed subjects. Overall, median levels of urinary individual and total OH-PAHs (ΣOH-PAHs) suggest an increased exposure to polycyclic aromatic hydrocarbons during firefighting activities with ΣOH-PAH levels in exposed firefighters 1.7-35 times higher than in non-exposed ones. Urinary 1-hydroxynaphthalene and/or 1-hydroxyacenapthene were the predominant compounds, representing 63-98% of ΣOH-PAHs, followed by 2-hydroxyfluorene (1-17%), 1-hydroxyphenanthrene (1-13%), and 1OHPy (0.3-10%). A similar profile was observed when gender discrimination was considered. Participation in fire combat activities promoted an increase of the distribution percentage of 1-hydroxynaphthalene and 1-hydroxyacenaphthene, while contributions of 1-hydroxyphenanthrene and 1OHPy decreased. The detected urinary 1OHPy concentrations (1.73×10(-2) to 0.152μmol/mol creatinine in exposed subjects versus 1.21×10(-2) to 5.44×10(-2)μmol/mol creatinine in non-exposed individuals) were lower than the benchmark level (0.5μmol/mol creatinine) proposed by the American Conference of Governmental Industrial Hygienists. This compound, considered the biomarker of exposure to PAHs, was the less abundant one from the six analyzed biomarkers. Thus the inclusion of other metabolites, in addition to 1OHPy, in future studies is suggested to better estimate firefighters' occupational exposure to PAHs. Moreover, strong to moderate Spearman correlations were observed between individual compounds and ΣOH-PAHs corroborating the prevalence of an emission source. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-07-15 2016-07-15T00:00:00Z 2020-07-16T00:30:11Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/4071 |
url |
http://hdl.handle.net/10400.18/4071 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Int J Hyg Environ Health. 2016 Nov;219(8):857-866. doi: 10.1016/j.ijheh.2016.07.011. Epub 2016 Jul 15. 1438-4639 10.1016/j.ijheh.2016.07.011 |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier/Urban and Fischer |
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Elsevier/Urban and Fischer |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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