Mitochondria and the heart
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2024 |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.1/20456 |
Resumo: | Cardiac work demands a substantial amount of energy, stored in adenosine triphosphate (ATP), necessary for both contraction and relaxation. To meet these energy requirements, the heart is equipped with an efficient metabolic machinery. Mitochondria, the central organelle in maintaining cardiac function, primarily generate ATP through oxidative phosphorylation, involving redox reactions coupled with a chemiosmotic process across their membranes. Additionally, mitochondria play a role in regulating cell death and survival and modulating second messenger levels, such as calcium ions (Ca2+) and reactive oxygen species (ROS). |
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Mitochondria and the heartCardiac work demands a substantial amount of energy, stored in adenosine triphosphate (ATP), necessary for both contraction and relaxation. To meet these energy requirements, the heart is equipped with an efficient metabolic machinery. Mitochondria, the central organelle in maintaining cardiac function, primarily generate ATP through oxidative phosphorylation, involving redox reactions coupled with a chemiosmotic process across their membranes. Additionally, mitochondria play a role in regulating cell death and survival and modulating second messenger levels, such as calcium ions (Ca2+) and reactive oxygen species (ROS).Oxford university pressSapientiaZuccolotto- Dos- Reis, Felippe Henrique2024-02-27T13:47:36Z2024-012024-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/20456eng10.1093/eurheartj/ehae0311522-9645info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-06T02:03:54Zoai:sapientia.ualg.pt:10400.1/20456Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:11:39.724423Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Mitochondria and the heart |
| title |
Mitochondria and the heart |
| spellingShingle |
Mitochondria and the heart Zuccolotto- Dos- Reis, Felippe Henrique |
| title_short |
Mitochondria and the heart |
| title_full |
Mitochondria and the heart |
| title_fullStr |
Mitochondria and the heart |
| title_full_unstemmed |
Mitochondria and the heart |
| title_sort |
Mitochondria and the heart |
| author |
Zuccolotto- Dos- Reis, Felippe Henrique |
| author_facet |
Zuccolotto- Dos- Reis, Felippe Henrique |
| author_role |
author |
| dc.contributor.none.fl_str_mv |
Sapientia |
| dc.contributor.author.fl_str_mv |
Zuccolotto- Dos- Reis, Felippe Henrique |
| description |
Cardiac work demands a substantial amount of energy, stored in adenosine triphosphate (ATP), necessary for both contraction and relaxation. To meet these energy requirements, the heart is equipped with an efficient metabolic machinery. Mitochondria, the central organelle in maintaining cardiac function, primarily generate ATP through oxidative phosphorylation, involving redox reactions coupled with a chemiosmotic process across their membranes. Additionally, mitochondria play a role in regulating cell death and survival and modulating second messenger levels, such as calcium ions (Ca2+) and reactive oxygen species (ROS). |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024-02-27T13:47:36Z 2024-01 2024-01-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10400.1/20456 |
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http://hdl.handle.net/10400.1/20456 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
10.1093/eurheartj/ehae031 1522-9645 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Oxford university press |
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Oxford university press |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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