Associations between Trace Elements and Cognitive Decline: An Exploratory 5-Year Follow-Up Study of an Elderly Cohort

• Autor(a) principal: Gerardo, Bianca
• Data de Publicação: 2020
• Outros Autores: Pinto, Marina Cabral, Nogueira, Joana, Pinto, Paula, Almeida, Agostinho, Pinto, Edgar, Marinho-Reis, Paula, Diniz, Luísa, Moreira, Paula I., Simões, Mário, Freitas, Sandra
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10316/106168; https://doi.org/10.3390/ijerph17176051
• topic: cognitive decline; human tissues; industrial area; longitudinal study; mining area; nickel; risk for dementia; selenium; trace elements; Aged; Follow-Up Studies; Humans; Mental Status and Dementia Tests; Nails; Neuropsychological Tests; Cognitive Dysfunction; Trace Elements

Trace elements (TE) homeostasis is crucial in normal brain functioning. Although imbalances have the potential to exacerbate events leading neurodegenerative diseases, few studies have directly addressed the eventual relationships between TE levels in the human body and future cognitive status. The present study aimed to assess how different TE body-levels relate to cognitive decline. This exploratory research included a study-group (RES) of 20 elderly individuals living in two Portuguese geographical areas of interest (Estarreja; Mértola), as well as a 20 subjects neuropsychological control-group (CTR). Participants were neuropsychologically assessed through the Mini Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) and the RES group was biomonitored for TE through fingernail analysis. After 5 years, the cognitive assessments were repeated. Analyses of the RES neuropsychological data showed an average decrease of 6.5 and 5.27 points in MMSE and MoCA, respectively, but TE contents in fingernails were generally within the referenced values for non-exposed individuals. Higher levels of Nickel and Selenium significantly predicted lesser cognitive decline within 5 years. Such preliminary results evidence an association between higher contents of these TE and higher cognitive scores at follow-up, suggesting their contribution to the maintenance of cognitive abilities. Future expansion of the present study is needed in order to comprehensively assess the potential benefits of these TE.