Spatiotemporal phosphoregulation of Lgl: Finding meaning in multiple on/off buttons
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10216/114510 |
Resumo: | Intracellular asymmetries, often termed cell polarity, determine how cells organize and divide to ultimately control cell fate and shape animal tissues. The tumor suppressor Lethal giant larvae (Lgl) functions at the core of the evolutionarily conserved cell polarity machinery that controls apico-basal polarization. This function relies on its restricted basolateral localization via phosphorylation by aPKC. Here, we summarize the spatial and temporal control of Lgl during the cell cycle, highlighting two ideas that emerged from our recent findings: 1) Aurora A directly phosphorylates Lgl during symmetric division to couple reorganization of epithelial polarity with the cell cycle; 2) Phosphorylation of Lgl within three conserved serines controls its localization and function in a site-specific manner. Considering the importance of phosphorylation to regulate the concentration of Lgl at the plasma membrane, we will further discuss how it may work as an on-off switch for the interaction with cortical binding partners, with implications on epithelial polarization and spindle orientation. |
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Spatiotemporal phosphoregulation of Lgl: Finding meaning in multiple on/off buttonsAnimalsAurora Kinase A/metabolismCell DivisionDrosophila Proteins/metabolismProtein Kinase C/metabolismSpindle Apparatus/physiologyTumor Suppressor Proteins/metabolismIntracellular asymmetries, often termed cell polarity, determine how cells organize and divide to ultimately control cell fate and shape animal tissues. The tumor suppressor Lethal giant larvae (Lgl) functions at the core of the evolutionarily conserved cell polarity machinery that controls apico-basal polarization. This function relies on its restricted basolateral localization via phosphorylation by aPKC. Here, we summarize the spatial and temporal control of Lgl during the cell cycle, highlighting two ideas that emerged from our recent findings: 1) Aurora A directly phosphorylates Lgl during symmetric division to couple reorganization of epithelial polarity with the cell cycle; 2) Phosphorylation of Lgl within three conserved serines controls its localization and function in a site-specific manner. Considering the importance of phosphorylation to regulate the concentration of Lgl at the plasma membrane, we will further discuss how it may work as an on-off switch for the interaction with cortical binding partners, with implications on epithelial polarization and spindle orientation.Taylor & Francis20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10216/114510eng1949-099210.1080/19490992.2016.1149290Moreira, SMorais-de-Sá, Einfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T15:29:23Zoai:repositorio-aberto.up.pt:10216/114510Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:24:48.758667Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Spatiotemporal phosphoregulation of Lgl: Finding meaning in multiple on/off buttons |
title |
Spatiotemporal phosphoregulation of Lgl: Finding meaning in multiple on/off buttons |
spellingShingle |
Spatiotemporal phosphoregulation of Lgl: Finding meaning in multiple on/off buttons Moreira, S Animals Aurora Kinase A/metabolism Cell Division Drosophila Proteins/metabolism Protein Kinase C/metabolism Spindle Apparatus/physiology Tumor Suppressor Proteins/metabolism |
title_short |
Spatiotemporal phosphoregulation of Lgl: Finding meaning in multiple on/off buttons |
title_full |
Spatiotemporal phosphoregulation of Lgl: Finding meaning in multiple on/off buttons |
title_fullStr |
Spatiotemporal phosphoregulation of Lgl: Finding meaning in multiple on/off buttons |
title_full_unstemmed |
Spatiotemporal phosphoregulation of Lgl: Finding meaning in multiple on/off buttons |
title_sort |
Spatiotemporal phosphoregulation of Lgl: Finding meaning in multiple on/off buttons |
author |
Moreira, S |
author_facet |
Moreira, S Morais-de-Sá, E |
author_role |
author |
author2 |
Morais-de-Sá, E |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Moreira, S Morais-de-Sá, E |
dc.subject.por.fl_str_mv |
Animals Aurora Kinase A/metabolism Cell Division Drosophila Proteins/metabolism Protein Kinase C/metabolism Spindle Apparatus/physiology Tumor Suppressor Proteins/metabolism |
topic |
Animals Aurora Kinase A/metabolism Cell Division Drosophila Proteins/metabolism Protein Kinase C/metabolism Spindle Apparatus/physiology Tumor Suppressor Proteins/metabolism |
description |
Intracellular asymmetries, often termed cell polarity, determine how cells organize and divide to ultimately control cell fate and shape animal tissues. The tumor suppressor Lethal giant larvae (Lgl) functions at the core of the evolutionarily conserved cell polarity machinery that controls apico-basal polarization. This function relies on its restricted basolateral localization via phosphorylation by aPKC. Here, we summarize the spatial and temporal control of Lgl during the cell cycle, highlighting two ideas that emerged from our recent findings: 1) Aurora A directly phosphorylates Lgl during symmetric division to couple reorganization of epithelial polarity with the cell cycle; 2) Phosphorylation of Lgl within three conserved serines controls its localization and function in a site-specific manner. Considering the importance of phosphorylation to regulate the concentration of Lgl at the plasma membrane, we will further discuss how it may work as an on-off switch for the interaction with cortical binding partners, with implications on epithelial polarization and spindle orientation. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016 2016-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10216/114510 |
url |
http://hdl.handle.net/10216/114510 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1949-0992 10.1080/19490992.2016.1149290 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Taylor & Francis |
publisher.none.fl_str_mv |
Taylor & Francis |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799136163091447808 |