A Randomized Study of Nutritional Supplementation in Patients with Unilateral Wet Age-Related Macular Degeneration
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/105299 https://doi.org/10.3390/nu13041253 |
Resumo: | The purpose of this study is evaluate the efficacy and safety of medicinal products containing the original Age-Related Eye Disease group (AREDS) formulation at doses approved in Europe (EU, control group; n = 59) with a product that adds DHA, lutein, zeaxanthin, resveratrol and hydroxytyrosol to the formula (intervention group; n = 50). This was a multicenter, randomized, observer-blinded trial conducted in patients aged 50 years or older diagnosed with unilateral exudative Age related Macular Degeneration AMD. At month 12, the intervention did not have a significant differential effect on visual acuity compared with the control group, with an estimated treatment difference in Early Treatment Diabetic Retinopathy Study (ETDRS) of -1.63 (95% CI -0.83 to 4.09; p = 0.192). The intervention exhibited a significant and, in most cases, relevant effect in terms of a reduction in some inflammatory cytokines and a greater improvement in the fatty acid profile and serum lutein and zeaxantin concentration. In patients with unilateral wet AMD, the addition of lutein, zeaxanthin, resveratrol, hydroxytyrosol and DHA to the AREDS EU recommended doses in the short-term did not have a differential effect on visual acuity compared to a standard AREDS EU formula but, in addition to improving the fatty acid profile and increasing carotenoid serum levels, may provide a beneficial effect in improving the proinflammatory and proangiogenic profile of patients with AMD. |
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A Randomized Study of Nutritional Supplementation in Patients with Unilateral Wet Age-Related Macular Degenerationage-related macular degenerationAREDSTheavit®Retilut®carotenoidspolyunsaturated fatty acidsinflammatory markersangiogenic factors at month 12The purpose of this study is evaluate the efficacy and safety of medicinal products containing the original Age-Related Eye Disease group (AREDS) formulation at doses approved in Europe (EU, control group; n = 59) with a product that adds DHA, lutein, zeaxanthin, resveratrol and hydroxytyrosol to the formula (intervention group; n = 50). This was a multicenter, randomized, observer-blinded trial conducted in patients aged 50 years or older diagnosed with unilateral exudative Age related Macular Degeneration AMD. At month 12, the intervention did not have a significant differential effect on visual acuity compared with the control group, with an estimated treatment difference in Early Treatment Diabetic Retinopathy Study (ETDRS) of -1.63 (95% CI -0.83 to 4.09; p = 0.192). The intervention exhibited a significant and, in most cases, relevant effect in terms of a reduction in some inflammatory cytokines and a greater improvement in the fatty acid profile and serum lutein and zeaxantin concentration. In patients with unilateral wet AMD, the addition of lutein, zeaxanthin, resveratrol, hydroxytyrosol and DHA to the AREDS EU recommended doses in the short-term did not have a differential effect on visual acuity compared to a standard AREDS EU formula but, in addition to improving the fatty acid profile and increasing carotenoid serum levels, may provide a beneficial effect in improving the proinflammatory and proangiogenic profile of patients with AMD.MDPI2021-04-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/105299http://hdl.handle.net/10316/105299https://doi.org/10.3390/nu13041253eng2072-6643339202322072-6643García-Layana, AlfredoRecalde, SergioHernandez, MariaAbraldes, Maximino J.Nascimento, JoãoHernández-Galilea, EmilianoOlmedilla-Alonso, BegoñaEscobar-Barranco, Jose JuanZapata, Miguel AngelSilva, RufinoCaballero Arredondo, MarianaLopez-Sabater, María CarmenMendez-Martínez, SilviaPardiñas-Barón, NievesCalvo, PilarFernández-Robredo, Patriciainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-02-15T12:03:53Zoai:estudogeral.uc.pt:10316/105299Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:21:53.754463Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
A Randomized Study of Nutritional Supplementation in Patients with Unilateral Wet Age-Related Macular Degeneration |
title |
A Randomized Study of Nutritional Supplementation in Patients with Unilateral Wet Age-Related Macular Degeneration |
spellingShingle |
A Randomized Study of Nutritional Supplementation in Patients with Unilateral Wet Age-Related Macular Degeneration García-Layana, Alfredo age-related macular degeneration AREDS Theavit® Retilut® carotenoids polyunsaturated fatty acids inflammatory markers angiogenic factors at month 12 |
title_short |
A Randomized Study of Nutritional Supplementation in Patients with Unilateral Wet Age-Related Macular Degeneration |
title_full |
A Randomized Study of Nutritional Supplementation in Patients with Unilateral Wet Age-Related Macular Degeneration |
title_fullStr |
A Randomized Study of Nutritional Supplementation in Patients with Unilateral Wet Age-Related Macular Degeneration |
title_full_unstemmed |
A Randomized Study of Nutritional Supplementation in Patients with Unilateral Wet Age-Related Macular Degeneration |
title_sort |
A Randomized Study of Nutritional Supplementation in Patients with Unilateral Wet Age-Related Macular Degeneration |
author |
García-Layana, Alfredo |
author_facet |
García-Layana, Alfredo Recalde, Sergio Hernandez, Maria Abraldes, Maximino J. Nascimento, João Hernández-Galilea, Emiliano Olmedilla-Alonso, Begoña Escobar-Barranco, Jose Juan Zapata, Miguel Angel Silva, Rufino Caballero Arredondo, Mariana Lopez-Sabater, María Carmen Mendez-Martínez, Silvia Pardiñas-Barón, Nieves Calvo, Pilar Fernández-Robredo, Patricia |
author_role |
author |
author2 |
Recalde, Sergio Hernandez, Maria Abraldes, Maximino J. Nascimento, João Hernández-Galilea, Emiliano Olmedilla-Alonso, Begoña Escobar-Barranco, Jose Juan Zapata, Miguel Angel Silva, Rufino Caballero Arredondo, Mariana Lopez-Sabater, María Carmen Mendez-Martínez, Silvia Pardiñas-Barón, Nieves Calvo, Pilar Fernández-Robredo, Patricia |
author2_role |
author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
García-Layana, Alfredo Recalde, Sergio Hernandez, Maria Abraldes, Maximino J. Nascimento, João Hernández-Galilea, Emiliano Olmedilla-Alonso, Begoña Escobar-Barranco, Jose Juan Zapata, Miguel Angel Silva, Rufino Caballero Arredondo, Mariana Lopez-Sabater, María Carmen Mendez-Martínez, Silvia Pardiñas-Barón, Nieves Calvo, Pilar Fernández-Robredo, Patricia |
dc.subject.por.fl_str_mv |
age-related macular degeneration AREDS Theavit® Retilut® carotenoids polyunsaturated fatty acids inflammatory markers angiogenic factors at month 12 |
topic |
age-related macular degeneration AREDS Theavit® Retilut® carotenoids polyunsaturated fatty acids inflammatory markers angiogenic factors at month 12 |
description |
The purpose of this study is evaluate the efficacy and safety of medicinal products containing the original Age-Related Eye Disease group (AREDS) formulation at doses approved in Europe (EU, control group; n = 59) with a product that adds DHA, lutein, zeaxanthin, resveratrol and hydroxytyrosol to the formula (intervention group; n = 50). This was a multicenter, randomized, observer-blinded trial conducted in patients aged 50 years or older diagnosed with unilateral exudative Age related Macular Degeneration AMD. At month 12, the intervention did not have a significant differential effect on visual acuity compared with the control group, with an estimated treatment difference in Early Treatment Diabetic Retinopathy Study (ETDRS) of -1.63 (95% CI -0.83 to 4.09; p = 0.192). The intervention exhibited a significant and, in most cases, relevant effect in terms of a reduction in some inflammatory cytokines and a greater improvement in the fatty acid profile and serum lutein and zeaxantin concentration. In patients with unilateral wet AMD, the addition of lutein, zeaxanthin, resveratrol, hydroxytyrosol and DHA to the AREDS EU recommended doses in the short-term did not have a differential effect on visual acuity compared to a standard AREDS EU formula but, in addition to improving the fatty acid profile and increasing carotenoid serum levels, may provide a beneficial effect in improving the proinflammatory and proangiogenic profile of patients with AMD. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-04-10 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/105299 http://hdl.handle.net/10316/105299 https://doi.org/10.3390/nu13041253 |
url |
http://hdl.handle.net/10316/105299 https://doi.org/10.3390/nu13041253 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2072-6643 33920232 2072-6643 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799134109471080448 |