Mesenchymal stem cells empowering tendon regenerative therapies

Detalhes bibliográficos
Autor(a) principal: Costa-Almeida, Raquel
Data de Publicação: 2019
Outros Autores: Calejo, Isabel, Gomes, Manuela E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/60696
Resumo: Tendon tissues have limited healing capacity. The incidence of tendon injuries and the unsatisfactory functional outcomes of tendon repair are driving the search for alternative therapeutic approaches envisioning tendon regeneration. Cellular therapies aim at delivering adequate, regeneration-competent cell types to the injured tendon and toward ultimately promoting its reconstruction and recovery of functionality. Mesenchymal stem cells (MSCs) either obtained from tendons or from non-tendon sources, like bone marrow (BM-MSCs) or adipose tissue (ASCs), have been receiving increasing attention over the years toward enhancing tendon healing. Evidences from in vitro and in vivo studies suggest MSCs can contribute to accelerate and improve the quality of tendon healing. Nonetheless, the exact mechanisms underlying these repair events are yet to be fully elucidated. This review provides an overview of the main challenges in the field of cell-based regenerative therapies, discussing the role of MSCs in boosting tendon regeneration, particularly through their capacity to enhance the tenogenic properties of tendon resident cells.
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spelling Mesenchymal stem cells empowering tendon regenerative therapiesadipose-derived stem cellsbone marrow derived stem cellscellular communicationExtracellular matrixtendon healingtendon stemprogenitor cellstenogenesisTendon stem/progenitor cellsScience & TechnologyTendon tissues have limited healing capacity. The incidence of tendon injuries and the unsatisfactory functional outcomes of tendon repair are driving the search for alternative therapeutic approaches envisioning tendon regeneration. Cellular therapies aim at delivering adequate, regeneration-competent cell types to the injured tendon and toward ultimately promoting its reconstruction and recovery of functionality. Mesenchymal stem cells (MSCs) either obtained from tendons or from non-tendon sources, like bone marrow (BM-MSCs) or adipose tissue (ASCs), have been receiving increasing attention over the years toward enhancing tendon healing. Evidences from in vitro and in vivo studies suggest MSCs can contribute to accelerate and improve the quality of tendon healing. Nonetheless, the exact mechanisms underlying these repair events are yet to be fully elucidated. This review provides an overview of the main challenges in the field of cell-based regenerative therapies, discussing the role of MSCs in boosting tendon regeneration, particularly through their capacity to enhance the tenogenic properties of tendon resident cells.The authors acknowledge the financial support from the European Union Framework Programme for Research and Innovation HORIZON2020, under the TEAMING Grant agreement No 739572-The Discoveries CTR, the ERC Grant CoG MagTendon nr 772817, and the Achilles Grant nr 810850, FCT-Fundacao para a Ciencia e a Tecnologia for the PhD grant of IC (PD/BD/128088/2016); and the Project NORTE-01-0145-FEDER-000021: "Accelerating tissue engineering and personalized medicine discoveries by the integration of key enabling nanotechnologies, marine-derived biomaterials and stem cells", supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF).info:eu-repo/semantics/publishedVersionMultidisciplinary Digital Publishing InstituteUniversidade do MinhoCosta-Almeida, RaquelCalejo, IsabelGomes, Manuela E.2019-06-192019-06-19T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/60696engCosta-Almeida, R.; Calejo, I.; Gomes, M.E. Mesenchymal Stem Cells Empowering Tendon Regenerative Therapies. Int. J. Mol. Sci. 2019, 20, 3002.1661-65961422-006710.3390/ijms2012300231248196https://www.mdpi.com/1422-0067/20/12/3002info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:01:13Zoai:repositorium.sdum.uminho.pt:1822/60696Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:51:08.689978Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Mesenchymal stem cells empowering tendon regenerative therapies
title Mesenchymal stem cells empowering tendon regenerative therapies
spellingShingle Mesenchymal stem cells empowering tendon regenerative therapies
Costa-Almeida, Raquel
adipose-derived stem cells
bone marrow derived stem cells
cellular communication
Extracellular matrix
tendon healing
tendon stem
progenitor cells
tenogenesis
Tendon stem/progenitor cells
Science & Technology
title_short Mesenchymal stem cells empowering tendon regenerative therapies
title_full Mesenchymal stem cells empowering tendon regenerative therapies
title_fullStr Mesenchymal stem cells empowering tendon regenerative therapies
title_full_unstemmed Mesenchymal stem cells empowering tendon regenerative therapies
title_sort Mesenchymal stem cells empowering tendon regenerative therapies
author Costa-Almeida, Raquel
author_facet Costa-Almeida, Raquel
Calejo, Isabel
Gomes, Manuela E.
author_role author
author2 Calejo, Isabel
Gomes, Manuela E.
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Costa-Almeida, Raquel
Calejo, Isabel
Gomes, Manuela E.
dc.subject.por.fl_str_mv adipose-derived stem cells
bone marrow derived stem cells
cellular communication
Extracellular matrix
tendon healing
tendon stem
progenitor cells
tenogenesis
Tendon stem/progenitor cells
Science & Technology
topic adipose-derived stem cells
bone marrow derived stem cells
cellular communication
Extracellular matrix
tendon healing
tendon stem
progenitor cells
tenogenesis
Tendon stem/progenitor cells
Science & Technology
description Tendon tissues have limited healing capacity. The incidence of tendon injuries and the unsatisfactory functional outcomes of tendon repair are driving the search for alternative therapeutic approaches envisioning tendon regeneration. Cellular therapies aim at delivering adequate, regeneration-competent cell types to the injured tendon and toward ultimately promoting its reconstruction and recovery of functionality. Mesenchymal stem cells (MSCs) either obtained from tendons or from non-tendon sources, like bone marrow (BM-MSCs) or adipose tissue (ASCs), have been receiving increasing attention over the years toward enhancing tendon healing. Evidences from in vitro and in vivo studies suggest MSCs can contribute to accelerate and improve the quality of tendon healing. Nonetheless, the exact mechanisms underlying these repair events are yet to be fully elucidated. This review provides an overview of the main challenges in the field of cell-based regenerative therapies, discussing the role of MSCs in boosting tendon regeneration, particularly through their capacity to enhance the tenogenic properties of tendon resident cells.
publishDate 2019
dc.date.none.fl_str_mv 2019-06-19
2019-06-19T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/60696
url http://hdl.handle.net/1822/60696
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Costa-Almeida, R.; Calejo, I.; Gomes, M.E. Mesenchymal Stem Cells Empowering Tendon Regenerative Therapies. Int. J. Mol. Sci. 2019, 20, 3002.
1661-6596
1422-0067
10.3390/ijms20123002
31248196
https://www.mdpi.com/1422-0067/20/12/3002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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