Modelling and Development of a Microfluidic Platform for Dielectrophoretic Separation of Polymeric Nanoparticles
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Tipo de documento: | Dissertação |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/112989 |
Resumo: | The interest surrounding particle separation techniques has increased significantly in the past years, due to its importance in chemical and biological analysis, diagnostics, and food processing, among other areas. Out of the vast array of ways that have been used to separate particles in microfluidics, electric field may be the most common means of separation, given its applicability and versatility. Dielectrophoresis (DEP) occurs in the presence of a non-uniform electric field, and in order to achieve such field, there are two main approaches: by creating an array of metal electrodes along the main channel or by utilizing an electrodeless design. This latter approach is based on creating constrictions on the channel while applying an electric field between the inlet(s) and outlet(s) of the channel. In this work, done in the Department of Materials and Production of the University of Aalborg, five different models were designed and fabricated on a single fused silica wafer via photolithography, with the ultimate purpose of continuously separating particles with diameters of 20 nm and 150 nm. A detailed overview of the designs and COMSOL simulations, as well as the fabrication techniques and processes can be found throughout the work. Successful particle separation was achieved in the simulations, at voltages as low as 35 V, with the use of separation channels with a maximum length of 3.1 mm. The fabrication stage of the work was focused on the development of a robust microfabrication process suitable for small, well-defined channels, and its alignment with metal electrodes. Two different fabrication approaches were presented and analysed. |
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Modelling and Development of a Microfluidic Platform for Dielectrophoretic Separation of Polymeric NanoparticlesMicrofluidicsParticle separationDielectrophoresisPhotolithographyCOMSOL MultiphysicsSU-8Domínio/Área Científica::Engenharia e Tecnologia::NanotecnologiaThe interest surrounding particle separation techniques has increased significantly in the past years, due to its importance in chemical and biological analysis, diagnostics, and food processing, among other areas. Out of the vast array of ways that have been used to separate particles in microfluidics, electric field may be the most common means of separation, given its applicability and versatility. Dielectrophoresis (DEP) occurs in the presence of a non-uniform electric field, and in order to achieve such field, there are two main approaches: by creating an array of metal electrodes along the main channel or by utilizing an electrodeless design. This latter approach is based on creating constrictions on the channel while applying an electric field between the inlet(s) and outlet(s) of the channel. In this work, done in the Department of Materials and Production of the University of Aalborg, five different models were designed and fabricated on a single fused silica wafer via photolithography, with the ultimate purpose of continuously separating particles with diameters of 20 nm and 150 nm. A detailed overview of the designs and COMSOL simulations, as well as the fabrication techniques and processes can be found throughout the work. Successful particle separation was achieved in the simulations, at voltages as low as 35 V, with the use of separation channels with a maximum length of 3.1 mm. The fabrication stage of the work was focused on the development of a robust microfabrication process suitable for small, well-defined channels, and its alignment with metal electrodes. Two different fabrication approaches were presented and analysed.Gurevich, LeonidSilva, AnaRUNRebordão, Guilherme Santos2021-03-03T17:11:39Z2019-112019-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10362/112989enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:56:16Zoai:run.unl.pt:10362/112989Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:42:15.272759Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Modelling and Development of a Microfluidic Platform for Dielectrophoretic Separation of Polymeric Nanoparticles |
title |
Modelling and Development of a Microfluidic Platform for Dielectrophoretic Separation of Polymeric Nanoparticles |
spellingShingle |
Modelling and Development of a Microfluidic Platform for Dielectrophoretic Separation of Polymeric Nanoparticles Rebordão, Guilherme Santos Microfluidics Particle separation Dielectrophoresis Photolithography COMSOL Multiphysics SU-8 Domínio/Área Científica::Engenharia e Tecnologia::Nanotecnologia |
title_short |
Modelling and Development of a Microfluidic Platform for Dielectrophoretic Separation of Polymeric Nanoparticles |
title_full |
Modelling and Development of a Microfluidic Platform for Dielectrophoretic Separation of Polymeric Nanoparticles |
title_fullStr |
Modelling and Development of a Microfluidic Platform for Dielectrophoretic Separation of Polymeric Nanoparticles |
title_full_unstemmed |
Modelling and Development of a Microfluidic Platform for Dielectrophoretic Separation of Polymeric Nanoparticles |
title_sort |
Modelling and Development of a Microfluidic Platform for Dielectrophoretic Separation of Polymeric Nanoparticles |
author |
Rebordão, Guilherme Santos |
author_facet |
Rebordão, Guilherme Santos |
author_role |
author |
dc.contributor.none.fl_str_mv |
Gurevich, Leonid Silva, Ana RUN |
dc.contributor.author.fl_str_mv |
Rebordão, Guilherme Santos |
dc.subject.por.fl_str_mv |
Microfluidics Particle separation Dielectrophoresis Photolithography COMSOL Multiphysics SU-8 Domínio/Área Científica::Engenharia e Tecnologia::Nanotecnologia |
topic |
Microfluidics Particle separation Dielectrophoresis Photolithography COMSOL Multiphysics SU-8 Domínio/Área Científica::Engenharia e Tecnologia::Nanotecnologia |
description |
The interest surrounding particle separation techniques has increased significantly in the past years, due to its importance in chemical and biological analysis, diagnostics, and food processing, among other areas. Out of the vast array of ways that have been used to separate particles in microfluidics, electric field may be the most common means of separation, given its applicability and versatility. Dielectrophoresis (DEP) occurs in the presence of a non-uniform electric field, and in order to achieve such field, there are two main approaches: by creating an array of metal electrodes along the main channel or by utilizing an electrodeless design. This latter approach is based on creating constrictions on the channel while applying an electric field between the inlet(s) and outlet(s) of the channel. In this work, done in the Department of Materials and Production of the University of Aalborg, five different models were designed and fabricated on a single fused silica wafer via photolithography, with the ultimate purpose of continuously separating particles with diameters of 20 nm and 150 nm. A detailed overview of the designs and COMSOL simulations, as well as the fabrication techniques and processes can be found throughout the work. Successful particle separation was achieved in the simulations, at voltages as low as 35 V, with the use of separation channels with a maximum length of 3.1 mm. The fabrication stage of the work was focused on the development of a robust microfabrication process suitable for small, well-defined channels, and its alignment with metal electrodes. Two different fabrication approaches were presented and analysed. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-11 2019-11-01T00:00:00Z 2021-03-03T17:11:39Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/112989 |
url |
http://hdl.handle.net/10362/112989 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799138034351865856 |