Competition and fixation of cohorts of adaptive mutations under Fisher geometrical model
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.7/695 |
Resumo: | One of the simplest models of adaptation to a new environment is Fisher's Geometric Model (FGM), in which populations move on a multidimensional landscape defined by the traits under selection. The predictions of this model have been found to be consistent with current observations of patterns of fitness increase in experimentally evolved populations. Recent studies investigated the dynamics of allele frequency change along adaptation of microbes to simple laboratory conditions and unveiled a dramatic pattern of competition between cohorts of mutations, i.e., multiple mutations simultaneously segregating and ultimately reaching fixation. Here, using simulations, we study the dynamics of phenotypic and genetic change as asexual populations under clonal interference climb a Fisherian landscape, and ask about the conditions under which FGM can display the simultaneous increase and fixation of multiple mutations-mutation cohorts-along the adaptive walk. We find that FGM under clonal interference, and with varying levels of pleiotropy, can reproduce the experimentally observed competition between different cohorts of mutations, some of which have a high probability of fixation along the adaptive walk. Overall, our results show that the surprising dynamics of mutation cohorts recently observed during experimental adaptation of microbial populations can be expected under one of the oldest and simplest theoretical models of adaptation-FGM. |
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Competition and fixation of cohorts of adaptive mutations under Fisher geometrical modelFisher Geometric ModelClonal interferenceGenetic hitchikingNatural selectionOne of the simplest models of adaptation to a new environment is Fisher's Geometric Model (FGM), in which populations move on a multidimensional landscape defined by the traits under selection. The predictions of this model have been found to be consistent with current observations of patterns of fitness increase in experimentally evolved populations. Recent studies investigated the dynamics of allele frequency change along adaptation of microbes to simple laboratory conditions and unveiled a dramatic pattern of competition between cohorts of mutations, i.e., multiple mutations simultaneously segregating and ultimately reaching fixation. Here, using simulations, we study the dynamics of phenotypic and genetic change as asexual populations under clonal interference climb a Fisherian landscape, and ask about the conditions under which FGM can display the simultaneous increase and fixation of multiple mutations-mutation cohorts-along the adaptive walk. We find that FGM under clonal interference, and with varying levels of pleiotropy, can reproduce the experimentally observed competition between different cohorts of mutations, some of which have a high probability of fixation along the adaptive walk. Overall, our results show that the surprising dynamics of mutation cohorts recently observed during experimental adaptation of microbial populations can be expected under one of the oldest and simplest theoretical models of adaptation-FGM.Fundação para a Ciência e a Tecnologia; LAO/ITQB; Conselho Nacional de Desenvolvimento CientÌfico e Tecnologico (CNPq).PeerJARCAMoura de Sousa, Jorge A.Alpedrinha, JoãoCampos, Paulo R.A.Gordo, Isabel2016-08-29T12:16:55Z2016-08-022016-08-02T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/10400.7/695engMoura de Sousa et al. (2016), Competition and fixation of cohorts of adaptive mutations under Fisher geometri- cal model. PeerJ 4:e2256; DOI 10.7717/peerj.225610.7717/peerj.2256info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:35:05Zoai:arca.igc.gulbenkian.pt:10400.7/695Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:55.668192Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Competition and fixation of cohorts of adaptive mutations under Fisher geometrical model |
title |
Competition and fixation of cohorts of adaptive mutations under Fisher geometrical model |
spellingShingle |
Competition and fixation of cohorts of adaptive mutations under Fisher geometrical model Moura de Sousa, Jorge A. Fisher Geometric Model Clonal interference Genetic hitchiking Natural selection |
title_short |
Competition and fixation of cohorts of adaptive mutations under Fisher geometrical model |
title_full |
Competition and fixation of cohorts of adaptive mutations under Fisher geometrical model |
title_fullStr |
Competition and fixation of cohorts of adaptive mutations under Fisher geometrical model |
title_full_unstemmed |
Competition and fixation of cohorts of adaptive mutations under Fisher geometrical model |
title_sort |
Competition and fixation of cohorts of adaptive mutations under Fisher geometrical model |
author |
Moura de Sousa, Jorge A. |
author_facet |
Moura de Sousa, Jorge A. Alpedrinha, João Campos, Paulo R.A. Gordo, Isabel |
author_role |
author |
author2 |
Alpedrinha, João Campos, Paulo R.A. Gordo, Isabel |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
ARCA |
dc.contributor.author.fl_str_mv |
Moura de Sousa, Jorge A. Alpedrinha, João Campos, Paulo R.A. Gordo, Isabel |
dc.subject.por.fl_str_mv |
Fisher Geometric Model Clonal interference Genetic hitchiking Natural selection |
topic |
Fisher Geometric Model Clonal interference Genetic hitchiking Natural selection |
description |
One of the simplest models of adaptation to a new environment is Fisher's Geometric Model (FGM), in which populations move on a multidimensional landscape defined by the traits under selection. The predictions of this model have been found to be consistent with current observations of patterns of fitness increase in experimentally evolved populations. Recent studies investigated the dynamics of allele frequency change along adaptation of microbes to simple laboratory conditions and unveiled a dramatic pattern of competition between cohorts of mutations, i.e., multiple mutations simultaneously segregating and ultimately reaching fixation. Here, using simulations, we study the dynamics of phenotypic and genetic change as asexual populations under clonal interference climb a Fisherian landscape, and ask about the conditions under which FGM can display the simultaneous increase and fixation of multiple mutations-mutation cohorts-along the adaptive walk. We find that FGM under clonal interference, and with varying levels of pleiotropy, can reproduce the experimentally observed competition between different cohorts of mutations, some of which have a high probability of fixation along the adaptive walk. Overall, our results show that the surprising dynamics of mutation cohorts recently observed during experimental adaptation of microbial populations can be expected under one of the oldest and simplest theoretical models of adaptation-FGM. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-08-29T12:16:55Z 2016-08-02 2016-08-02T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.7/695 |
url |
http://hdl.handle.net/10400.7/695 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Moura de Sousa et al. (2016), Competition and fixation of cohorts of adaptive mutations under Fisher geometri- cal model. PeerJ 4:e2256; DOI 10.7717/peerj.2256 10.7717/peerj.2256 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
PeerJ |
publisher.none.fl_str_mv |
PeerJ |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799130574698315776 |