Association of peripheral blood and cutaneous eosinophils with bullous pemphigoid disease severity and treatment outcomes

Detalhes bibliográficos
Autor(a) principal: Garrido, Pedro
Data de Publicação: 2022
Outros Autores: Aguado Lobo, Marta, Espinosa Lara, Pablo, Soares-de-Almeida, Luís, Filipe, Paulo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/54751
Resumo: © 2022 AEDV. Published by Elsevier España, S.L.U. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).
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spelling Association of peripheral blood and cutaneous eosinophils with bullous pemphigoid disease severity and treatment outcomesAsociación entre eosinófilos de sangre periférica y cutáneos con la gravedad del penfigoide ampolloso y los resultados terapéuticosBullous dermatosisBullous pemphigoidEosinophiliaEosinophils© 2022 AEDV. Published by Elsevier España, S.L.U. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).Background and aims: A dermal inflammatory infiltrate rich in eosinophils is a prominent histological feature of bullous pemphigoid (BP) and peripheral blood eosinophilia has been documented in 50-60% of BP patients. Nevertheless, the impact of circulating and dermal infiltrate eosinophil levels on BP remains poorly understood. The main objective of this work was to investigate the association of peripheral blood and dermal infiltrate eosinophil levels with clinical and immunological characteristics of the disease. Material and methods: Retrospective cohort study including all patients diagnosed with BP between 2011 and 2020. Results: The study cohort included 233 patients with BP. The mean baseline peripheral blood eosinophil count was 956.3 ± 408.6 × 106/L and the mean number of tissue eosinophils at the dermal hot spot area was 30.5 ± 19.0. Patients with disseminated presentation (i.e. BSA > 50%) had significantly higher peripheral blood eosinophil counts (P = .028). Mucosal involvement was significantly associated with lower dermal eosinophil count (P = .001). Requiring inpatient care and relapsing were significantly associated with high peripheral blood eosinophil count (P = .025; P = .020, respectively). Among the 68 patients who experienced a relapse, 31 had peripheral blood eosinophilia (i.e. > 500 × 106/L) at relapse (44.2%). Peripheral blood eosinophil counts at baseline and at relapse were significantly correlated (r = 0.82, P < .001). Conclusions: Peripheral blood and cutaneous eosinophils levels may be useful biomarkers for disease activity and treatment outcomes in BP. Monitoring peripheral blood eosinophil counts may allow early detection of relapse.ElsevierRepositório da Universidade de LisboaGarrido, PedroAguado Lobo, MartaEspinosa Lara, PabloSoares-de-Almeida, LuísFilipe, Paulo2022-10-12T15:10:06Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/54751engActas Dermosifiliogr. 2022 Oct;113(9):T881-T8870001-731010.1016/j.ad.2022.05.0211578-2190info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:01:19Zoai:repositorio.ul.pt:10451/54751Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:05:31.182017Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Association of peripheral blood and cutaneous eosinophils with bullous pemphigoid disease severity and treatment outcomes
Asociación entre eosinófilos de sangre periférica y cutáneos con la gravedad del penfigoide ampolloso y los resultados terapéuticos
title Association of peripheral blood and cutaneous eosinophils with bullous pemphigoid disease severity and treatment outcomes
spellingShingle Association of peripheral blood and cutaneous eosinophils with bullous pemphigoid disease severity and treatment outcomes
Garrido, Pedro
Bullous dermatosis
Bullous pemphigoid
Eosinophilia
Eosinophils
title_short Association of peripheral blood and cutaneous eosinophils with bullous pemphigoid disease severity and treatment outcomes
title_full Association of peripheral blood and cutaneous eosinophils with bullous pemphigoid disease severity and treatment outcomes
title_fullStr Association of peripheral blood and cutaneous eosinophils with bullous pemphigoid disease severity and treatment outcomes
title_full_unstemmed Association of peripheral blood and cutaneous eosinophils with bullous pemphigoid disease severity and treatment outcomes
title_sort Association of peripheral blood and cutaneous eosinophils with bullous pemphigoid disease severity and treatment outcomes
author Garrido, Pedro
author_facet Garrido, Pedro
Aguado Lobo, Marta
Espinosa Lara, Pablo
Soares-de-Almeida, Luís
Filipe, Paulo
author_role author
author2 Aguado Lobo, Marta
Espinosa Lara, Pablo
Soares-de-Almeida, Luís
Filipe, Paulo
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Garrido, Pedro
Aguado Lobo, Marta
Espinosa Lara, Pablo
Soares-de-Almeida, Luís
Filipe, Paulo
dc.subject.por.fl_str_mv Bullous dermatosis
Bullous pemphigoid
Eosinophilia
Eosinophils
topic Bullous dermatosis
Bullous pemphigoid
Eosinophilia
Eosinophils
description © 2022 AEDV. Published by Elsevier España, S.L.U. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).
publishDate 2022
dc.date.none.fl_str_mv 2022-10-12T15:10:06Z
2022
2022-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/54751
url http://hdl.handle.net/10451/54751
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Actas Dermosifiliogr. 2022 Oct;113(9):T881-T887
0001-7310
10.1016/j.ad.2022.05.021
1578-2190
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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