Comparison of Different Metrics for the Identification of Vascular Changes in Diabetic Retinopathy Using OCTA
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/104547 https://doi.org/10.3389/fnins.2021.755730 |
Resumo: | Retinal vessel metrics identifying microvascular changes such as vessel closure (VC) have shown potential clinical value by identifying eyes with diabetic retinopathy (DR) at different severity levels and at increased risk for disease progression to more severe stages. We compare the performance of 11 different metrics, which include 2 metrics supplied by the manufacturer, based on OCTA for identification of VC in different Early Treatment for Diabetic Retinopathy Study (ETDRS) severity groups. OCTA en-face slabs from 84 healthy eyes (70 ± 4.8 years) and 78 eyes of diabetic individuals (67 ± 7.5 years) were processed using different methods that include abnormal intercapillary spaces (AIS), vessel density (VD), and nine metrics extracted from the en-face slab. The best separation between the eyes with DR and the control group was obtained in the superficial capillary plexus (SCP), with the full retina (FR) also performing well. In the SCP, the metrics that show better performance were the AIS and the VD with a value of area under curve (AUC) equal to 0.89 [95% CI 0.84-0.94] and 0.85 [95% CI 0.79-0.91], respectively, indicating that the VD metric supported by the manufacturer is satisfactory. The values of these metrics on the different ETDRS groups show a progressive increase in VC, which is correlated with disease severity. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Comparison of Different Metrics for the Identification of Vascular Changes in Diabetic Retinopathy Using OCTAOCTAdiabetesretinaretinopathyvascularRetinal vessel metrics identifying microvascular changes such as vessel closure (VC) have shown potential clinical value by identifying eyes with diabetic retinopathy (DR) at different severity levels and at increased risk for disease progression to more severe stages. We compare the performance of 11 different metrics, which include 2 metrics supplied by the manufacturer, based on OCTA for identification of VC in different Early Treatment for Diabetic Retinopathy Study (ETDRS) severity groups. OCTA en-face slabs from 84 healthy eyes (70 ± 4.8 years) and 78 eyes of diabetic individuals (67 ± 7.5 years) were processed using different methods that include abnormal intercapillary spaces (AIS), vessel density (VD), and nine metrics extracted from the en-face slab. The best separation between the eyes with DR and the control group was obtained in the superficial capillary plexus (SCP), with the full retina (FR) also performing well. In the SCP, the metrics that show better performance were the AIS and the VD with a value of area under curve (AUC) equal to 0.89 [95% CI 0.84-0.94] and 0.85 [95% CI 0.79-0.91], respectively, indicating that the VD metric supported by the manufacturer is satisfactory. The values of these metrics on the different ETDRS groups show a progressive increase in VC, which is correlated with disease severity.Frontiers Media S.A.2021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/104547http://hdl.handle.net/10316/104547https://doi.org/10.3389/fnins.2021.755730eng1662-4548Mendes, LuísMarques, Inês P.Cunha-Vaz, Joséinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-01-17T21:47:26ZPortal AgregadorONG |
dc.title.none.fl_str_mv |
Comparison of Different Metrics for the Identification of Vascular Changes in Diabetic Retinopathy Using OCTA |
title |
Comparison of Different Metrics for the Identification of Vascular Changes in Diabetic Retinopathy Using OCTA |
spellingShingle |
Comparison of Different Metrics for the Identification of Vascular Changes in Diabetic Retinopathy Using OCTA Mendes, Luís OCTA diabetes retina retinopathy vascular |
title_short |
Comparison of Different Metrics for the Identification of Vascular Changes in Diabetic Retinopathy Using OCTA |
title_full |
Comparison of Different Metrics for the Identification of Vascular Changes in Diabetic Retinopathy Using OCTA |
title_fullStr |
Comparison of Different Metrics for the Identification of Vascular Changes in Diabetic Retinopathy Using OCTA |
title_full_unstemmed |
Comparison of Different Metrics for the Identification of Vascular Changes in Diabetic Retinopathy Using OCTA |
title_sort |
Comparison of Different Metrics for the Identification of Vascular Changes in Diabetic Retinopathy Using OCTA |
author |
Mendes, Luís |
author_facet |
Mendes, Luís Marques, Inês P. Cunha-Vaz, José |
author_role |
author |
author2 |
Marques, Inês P. Cunha-Vaz, José |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Mendes, Luís Marques, Inês P. Cunha-Vaz, José |
dc.subject.por.fl_str_mv |
OCTA diabetes retina retinopathy vascular |
topic |
OCTA diabetes retina retinopathy vascular |
description |
Retinal vessel metrics identifying microvascular changes such as vessel closure (VC) have shown potential clinical value by identifying eyes with diabetic retinopathy (DR) at different severity levels and at increased risk for disease progression to more severe stages. We compare the performance of 11 different metrics, which include 2 metrics supplied by the manufacturer, based on OCTA for identification of VC in different Early Treatment for Diabetic Retinopathy Study (ETDRS) severity groups. OCTA en-face slabs from 84 healthy eyes (70 ± 4.8 years) and 78 eyes of diabetic individuals (67 ± 7.5 years) were processed using different methods that include abnormal intercapillary spaces (AIS), vessel density (VD), and nine metrics extracted from the en-face slab. The best separation between the eyes with DR and the control group was obtained in the superficial capillary plexus (SCP), with the full retina (FR) also performing well. In the SCP, the metrics that show better performance were the AIS and the VD with a value of area under curve (AUC) equal to 0.89 [95% CI 0.84-0.94] and 0.85 [95% CI 0.79-0.91], respectively, indicating that the VD metric supported by the manufacturer is satisfactory. The values of these metrics on the different ETDRS groups show a progressive increase in VC, which is correlated with disease severity. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/104547 http://hdl.handle.net/10316/104547 https://doi.org/10.3389/fnins.2021.755730 |
url |
http://hdl.handle.net/10316/104547 https://doi.org/10.3389/fnins.2021.755730 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1662-4548 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Frontiers Media S.A. |
publisher.none.fl_str_mv |
Frontiers Media S.A. |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
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_version_ |
1777302817222950912 |