Endothelial progenitor cells and integrins: Adhesive needs
Autor(a) principal: | |
---|---|
Data de Publicação: | 2012 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.1186/1755-1536-5-4 |
Resumo: | In the last decade there have been multiple studies concerning the contribution of endothelial progenitor cells (EPCs) to new vessel formation in different physiological and pathological settings. The process by which EPCs contribute to new vessel formation in adults is termed postnatal vasculogenesis and occurs via four inter-related steps. They must respond to chemoattractant signals and mobilize from the bone marrow to the peripheral blood; home in on sites of new vessel formation; invade and migrate at the same sites; and differentiate into mature endothelial cells (ECs) and/or regulate pre-existing ECs via paracrine or juxtacrine signals. During these four steps, EPCs interact with different physiological compartments, namely bone marrow, peripheral blood, blood vessels and homing tissues. The success of each step depends on the ability of EPCs to interact, adapt and respond to multiple molecular cues. The present review summarizes the interactions between integrins expressed by EPCs and their ligands: extracellular matrix components and cell surface proteins present at sites of postnatal vasculogenesis. The data summarized here indicate that integrins represent a major molecular determinant of EPC function, with different integrin subunits regulating different steps of EPC biology. Specifically, integrin α4β1 is a key regulator of EPC retention and/or mobilization from the bone marrow, while integrins α5β1, α6β1, αvβ3 and αvβ5 are major determinants of EPC homing, invasion, differentiation and paracrine factor production. β2 integrins are the major regulators of EPC transendothelial migration. The relevance of integrins in EPC biology is also demonstrated by many studies that use extracellular matrix-based scaffolds as a clinical tool to improve the vasculogenic functions of EPCs. We propose that targeted and tissue-specific manipulation of EPC integrin-mediated interactions may be crucial to further improve the usage of this cell population as a relevant clinical agent. © 2012 Caiado and Dias; licensee BioMed Central Ltd. |
id |
RCAP_12e92dfbf796815e3550c3f7abc115e7 |
---|---|
oai_identifier_str |
oai:run.unl.pt:10362/23940 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Endothelial progenitor cells and integrins: Adhesive needsalpha4 integrinbeta3 integrinCD133 antigenCD34 antigenintegrintoll like receptor adaptor molecule 1vascular cell adhesion molecule 1vasculotropinvasculotropin receptor 2angiogenesiscell activitycell adhesioncell compartmentalizationcell differentiationcell functioncell homingcell interactioncell invasioncell migrationcell populationcell proliferationcell survivalcytologyendothelial progenitor cellextracellular matrixhematopoietic stem cellhumanmolecular biologynonhumanpostnatal developmentprotein expressionprotein interactionreviewstem cell mobilizationtarget celltissue blood flowtissue regenerationtissue repairtissue specificitytransendothelial and transepithelial migrationIn the last decade there have been multiple studies concerning the contribution of endothelial progenitor cells (EPCs) to new vessel formation in different physiological and pathological settings. The process by which EPCs contribute to new vessel formation in adults is termed postnatal vasculogenesis and occurs via four inter-related steps. They must respond to chemoattractant signals and mobilize from the bone marrow to the peripheral blood; home in on sites of new vessel formation; invade and migrate at the same sites; and differentiate into mature endothelial cells (ECs) and/or regulate pre-existing ECs via paracrine or juxtacrine signals. During these four steps, EPCs interact with different physiological compartments, namely bone marrow, peripheral blood, blood vessels and homing tissues. The success of each step depends on the ability of EPCs to interact, adapt and respond to multiple molecular cues. The present review summarizes the interactions between integrins expressed by EPCs and their ligands: extracellular matrix components and cell surface proteins present at sites of postnatal vasculogenesis. The data summarized here indicate that integrins represent a major molecular determinant of EPC function, with different integrin subunits regulating different steps of EPC biology. Specifically, integrin α4β1 is a key regulator of EPC retention and/or mobilization from the bone marrow, while integrins α5β1, α6β1, αvβ3 and αvβ5 are major determinants of EPC homing, invasion, differentiation and paracrine factor production. β2 integrins are the major regulators of EPC transendothelial migration. The relevance of integrins in EPC biology is also demonstrated by many studies that use extracellular matrix-based scaffolds as a clinical tool to improve the vasculogenic functions of EPCs. We propose that targeted and tissue-specific manipulation of EPC integrin-mediated interactions may be crucial to further improve the usage of this cell population as a relevant clinical agent. © 2012 Caiado and Dias; licensee BioMed Central Ltd.Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNCaiado, F.Dias, Sérgio2017-10-06T22:02:24Z2012-032012-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article13application/pdfhttps://doi.org/10.1186/1755-1536-5-4eng1755-1536PURE: 3165967https://www.scopus.com/inward/record.uri?eid=2-s2.0-84859621920&doi=10.1186%2f1755-1536-5-4&partnerID=40&md5=98993cc23b2fb07e39ee032b86637f08https://doi.org/10.1186/1755-1536-5-4info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:12:19Zoai:run.unl.pt:10362/23940Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:27:56.451522Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Endothelial progenitor cells and integrins: Adhesive needs |
title |
Endothelial progenitor cells and integrins: Adhesive needs |
spellingShingle |
Endothelial progenitor cells and integrins: Adhesive needs Caiado, F. alpha4 integrin beta3 integrin CD133 antigen CD34 antigen integrin toll like receptor adaptor molecule 1 vascular cell adhesion molecule 1 vasculotropin vasculotropin receptor 2 angiogenesis cell activity cell adhesion cell compartmentalization cell differentiation cell function cell homing cell interaction cell invasion cell migration cell population cell proliferation cell survival cytology endothelial progenitor cell extracellular matrix hematopoietic stem cell human molecular biology nonhuman postnatal development protein expression protein interaction review stem cell mobilization target cell tissue blood flow tissue regeneration tissue repair tissue specificity transendothelial and transepithelial migration |
title_short |
Endothelial progenitor cells and integrins: Adhesive needs |
title_full |
Endothelial progenitor cells and integrins: Adhesive needs |
title_fullStr |
Endothelial progenitor cells and integrins: Adhesive needs |
title_full_unstemmed |
Endothelial progenitor cells and integrins: Adhesive needs |
title_sort |
Endothelial progenitor cells and integrins: Adhesive needs |
author |
Caiado, F. |
author_facet |
Caiado, F. Dias, Sérgio |
author_role |
author |
author2 |
Dias, Sérgio |
author2_role |
author |
dc.contributor.none.fl_str_mv |
Centro de Estudos de Doenças Crónicas (CEDOC) NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
dc.contributor.author.fl_str_mv |
Caiado, F. Dias, Sérgio |
dc.subject.por.fl_str_mv |
alpha4 integrin beta3 integrin CD133 antigen CD34 antigen integrin toll like receptor adaptor molecule 1 vascular cell adhesion molecule 1 vasculotropin vasculotropin receptor 2 angiogenesis cell activity cell adhesion cell compartmentalization cell differentiation cell function cell homing cell interaction cell invasion cell migration cell population cell proliferation cell survival cytology endothelial progenitor cell extracellular matrix hematopoietic stem cell human molecular biology nonhuman postnatal development protein expression protein interaction review stem cell mobilization target cell tissue blood flow tissue regeneration tissue repair tissue specificity transendothelial and transepithelial migration |
topic |
alpha4 integrin beta3 integrin CD133 antigen CD34 antigen integrin toll like receptor adaptor molecule 1 vascular cell adhesion molecule 1 vasculotropin vasculotropin receptor 2 angiogenesis cell activity cell adhesion cell compartmentalization cell differentiation cell function cell homing cell interaction cell invasion cell migration cell population cell proliferation cell survival cytology endothelial progenitor cell extracellular matrix hematopoietic stem cell human molecular biology nonhuman postnatal development protein expression protein interaction review stem cell mobilization target cell tissue blood flow tissue regeneration tissue repair tissue specificity transendothelial and transepithelial migration |
description |
In the last decade there have been multiple studies concerning the contribution of endothelial progenitor cells (EPCs) to new vessel formation in different physiological and pathological settings. The process by which EPCs contribute to new vessel formation in adults is termed postnatal vasculogenesis and occurs via four inter-related steps. They must respond to chemoattractant signals and mobilize from the bone marrow to the peripheral blood; home in on sites of new vessel formation; invade and migrate at the same sites; and differentiate into mature endothelial cells (ECs) and/or regulate pre-existing ECs via paracrine or juxtacrine signals. During these four steps, EPCs interact with different physiological compartments, namely bone marrow, peripheral blood, blood vessels and homing tissues. The success of each step depends on the ability of EPCs to interact, adapt and respond to multiple molecular cues. The present review summarizes the interactions between integrins expressed by EPCs and their ligands: extracellular matrix components and cell surface proteins present at sites of postnatal vasculogenesis. The data summarized here indicate that integrins represent a major molecular determinant of EPC function, with different integrin subunits regulating different steps of EPC biology. Specifically, integrin α4β1 is a key regulator of EPC retention and/or mobilization from the bone marrow, while integrins α5β1, α6β1, αvβ3 and αvβ5 are major determinants of EPC homing, invasion, differentiation and paracrine factor production. β2 integrins are the major regulators of EPC transendothelial migration. The relevance of integrins in EPC biology is also demonstrated by many studies that use extracellular matrix-based scaffolds as a clinical tool to improve the vasculogenic functions of EPCs. We propose that targeted and tissue-specific manipulation of EPC integrin-mediated interactions may be crucial to further improve the usage of this cell population as a relevant clinical agent. © 2012 Caiado and Dias; licensee BioMed Central Ltd. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-03 2012-03-01T00:00:00Z 2017-10-06T22:02:24Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.1186/1755-1536-5-4 |
url |
https://doi.org/10.1186/1755-1536-5-4 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1755-1536 PURE: 3165967 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84859621920&doi=10.1186%2f1755-1536-5-4&partnerID=40&md5=98993cc23b2fb07e39ee032b86637f08 https://doi.org/10.1186/1755-1536-5-4 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
13 application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799137906564005888 |