Choroidal thinning
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.1016/j.dadm.2017.03.004 |
Resumo: | Introduction The purpose of this study was to measure and to compare macular choroidal thickness (CT) between patients with mild Alzheimer's disease (AD), patients without AD, and elderly patients. Methods CT was measured manually in 13 locations at 500-μm intervals of a horizontal and a vertical section from the fovea. Linear regression models were used to analyze the data. Results Fifty patients with a diagnosis of mild AD (73.1 years), 152 patients without AD (71.03 years), and 50 elderly without AD (82.14 years) were included. In the AD patients, CT was significantly thinner in all 13 locations (P < .001—comparing with age-match group), and comparing with the elderly group, a more pronounced difference was found in two locations temporal to the fovea. Discussion Patients with AD showed a significant choroidal thinning even when compared with elderly subjects. The reduction of CT may aid in the diagnoses of AD, probably reflecting the importance of vascular factors in their pathogenesis. |
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Choroidal thinningAlzheimer's disease and agingAgingAlzheimer's choroidopathyAlzheimer's diseaseChoroidal thicknessEnhanced depth imagingSpectral-domain optical coherence tomographyClinical NeurologyPsychiatry and Mental healthSDG 3 - Good Health and Well-beingIntroduction The purpose of this study was to measure and to compare macular choroidal thickness (CT) between patients with mild Alzheimer's disease (AD), patients without AD, and elderly patients. Methods CT was measured manually in 13 locations at 500-μm intervals of a horizontal and a vertical section from the fovea. Linear regression models were used to analyze the data. Results Fifty patients with a diagnosis of mild AD (73.1 years), 152 patients without AD (71.03 years), and 50 elderly without AD (82.14 years) were included. In the AD patients, CT was significantly thinner in all 13 locations (P < .001—comparing with age-match group), and comparing with the elderly group, a more pronounced difference was found in two locations temporal to the fovea. Discussion Patients with AD showed a significant choroidal thinning even when compared with elderly subjects. The reduction of CT may aid in the diagnoses of AD, probably reflecting the importance of vascular factors in their pathogenesis.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNCunha, João PauloProença, RitaDias-Santos, ArnaldoMelancia, DianaAlmeida, RitaÁguas, HelenaSantos, Bruno OliveiraAlves, MartaFerreira, JoanaPapoila, Ana LuísaLouro, CarlotaCastanheira-Dinis, António2017-09-29T22:04:10Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article7application/pdfhttps://doi.org/10.1016/j.dadm.2017.03.004eng2352-8729PURE: 3157121http://www.scopus.com/inward/record.url?scp=85017291672&partnerID=8YFLogxKhttps://doi.org/10.1016/j.dadm.2017.03.004info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:12:02Zoai:run.unl.pt:10362/23740Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:27:53.066782Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Choroidal thinning Alzheimer's disease and aging |
title |
Choroidal thinning |
spellingShingle |
Choroidal thinning Cunha, João Paulo Aging Alzheimer's choroidopathy Alzheimer's disease Choroidal thickness Enhanced depth imaging Spectral-domain optical coherence tomography Clinical Neurology Psychiatry and Mental health SDG 3 - Good Health and Well-being |
title_short |
Choroidal thinning |
title_full |
Choroidal thinning |
title_fullStr |
Choroidal thinning |
title_full_unstemmed |
Choroidal thinning |
title_sort |
Choroidal thinning |
author |
Cunha, João Paulo |
author_facet |
Cunha, João Paulo Proença, Rita Dias-Santos, Arnaldo Melancia, Diana Almeida, Rita Águas, Helena Santos, Bruno Oliveira Alves, Marta Ferreira, Joana Papoila, Ana Luísa Louro, Carlota Castanheira-Dinis, António |
author_role |
author |
author2 |
Proença, Rita Dias-Santos, Arnaldo Melancia, Diana Almeida, Rita Águas, Helena Santos, Bruno Oliveira Alves, Marta Ferreira, Joana Papoila, Ana Luísa Louro, Carlota Castanheira-Dinis, António |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
dc.contributor.author.fl_str_mv |
Cunha, João Paulo Proença, Rita Dias-Santos, Arnaldo Melancia, Diana Almeida, Rita Águas, Helena Santos, Bruno Oliveira Alves, Marta Ferreira, Joana Papoila, Ana Luísa Louro, Carlota Castanheira-Dinis, António |
dc.subject.por.fl_str_mv |
Aging Alzheimer's choroidopathy Alzheimer's disease Choroidal thickness Enhanced depth imaging Spectral-domain optical coherence tomography Clinical Neurology Psychiatry and Mental health SDG 3 - Good Health and Well-being |
topic |
Aging Alzheimer's choroidopathy Alzheimer's disease Choroidal thickness Enhanced depth imaging Spectral-domain optical coherence tomography Clinical Neurology Psychiatry and Mental health SDG 3 - Good Health and Well-being |
description |
Introduction The purpose of this study was to measure and to compare macular choroidal thickness (CT) between patients with mild Alzheimer's disease (AD), patients without AD, and elderly patients. Methods CT was measured manually in 13 locations at 500-μm intervals of a horizontal and a vertical section from the fovea. Linear regression models were used to analyze the data. Results Fifty patients with a diagnosis of mild AD (73.1 years), 152 patients without AD (71.03 years), and 50 elderly without AD (82.14 years) were included. In the AD patients, CT was significantly thinner in all 13 locations (P < .001—comparing with age-match group), and comparing with the elderly group, a more pronounced difference was found in two locations temporal to the fovea. Discussion Patients with AD showed a significant choroidal thinning even when compared with elderly subjects. The reduction of CT may aid in the diagnoses of AD, probably reflecting the importance of vascular factors in their pathogenesis. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-09-29T22:04:10Z 2017 2017-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.1016/j.dadm.2017.03.004 |
url |
https://doi.org/10.1016/j.dadm.2017.03.004 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2352-8729 PURE: 3157121 http://www.scopus.com/inward/record.url?scp=85017291672&partnerID=8YFLogxK https://doi.org/10.1016/j.dadm.2017.03.004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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7 application/pdf |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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