3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine

Detalhes bibliográficos
Autor(a) principal: Clement, Cristina C.
Data de Publicação: 2021
Outros Autores: D’Alessandro, Angelo, Thangaswamy, Sangeetha, Chalmers, Samantha, Furtado, Raquel, Spada, Sheila, Mondanelli, Giada, Ianni, Federica, Gehrke, Sarah, Gargaro, Marco, Manni, Giorgia, Cara, Luisa Carlota Lopez, Runge, Peter, Tsai, Wanxia Li, Karaman, Sinem, Arasa, Jorge, Fernandez-Rodriguez, Ruben, Beck, Amanda, Macchiarulo, Antonio, Gadina, Massimo, Halin, Cornelia, Fallarino, Francesca, Skobe, Mihaela, Veldhoen, Marc, Moretti, Simone, Formenti, Silvia, Demaria, Sandra, Soni, Rajesh K., Galarini, Roberta, Sardella, Roccaldo, Lauvau, Gregoire, Putterman, Chaim, Alitalo, Kari, Grohmann, Ursula, Santambrogio, Laura
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/49217
Resumo: © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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spelling 3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amineAutoimmunityInflammationSkin diseases© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.Tryptophan catabolism is a major metabolic pathway utilized by several professional and non-professional antigen presenting cells to maintain immunological tolerance. Here we report that 3-hydroxy-L-kynurenamine (3-HKA) is a biogenic amine produced via an alternative pathway of tryptophan metabolism. In vitro, 3-HKA has an anti-inflammatory profile by inhibiting the IFN-γ mediated STAT1/NF-κΒ pathway in both mouse and human dendritic cells (DCs) with a consequent decrease in the release of pro-inflammatory chemokines and cytokines, most notably TNF, IL-6, and IL12p70. 3-HKA has protective effects in an experimental mouse model of psoriasis by decreasing skin thickness, erythema, scaling and fissuring, reducing TNF, IL-1β, IFN-γ, and IL-17 production, and inhibiting generation of effector CD8+ T cells. Similarly, in a mouse model of nephrotoxic nephritis, besides reducing inflammatory cytokines, 3-HKA improves proteinuria and serum urea nitrogen, overall ameliorating immune-mediated glomerulonephritis and renal dysfunction. Overall, we propose that this biogenic amine is a crucial component of tryptophan-mediated immune tolerance.The work was supported by the following grants: NIH-AG045223 and NIH-AI137198 to L.S.; the Swiss National Science Foundation, grant 310030_182528 to C.H.; Telethon GGP17094 and the Associazione Italiana per la Ricerca sul Cancro (AIRC; 19903) to F.F.; Sigrid Juselius Foundation to K.A.; NIH T32 DK007110 to S.C.; NIH-AI103338 and NIH-AI138552 to G.L.; NIH K12 GM102779/BETTR program to R.F.; Associazione Italiana per la Ricerca sul Cancro (AIRC 2019-23084) to U.G.; The Intramural Research Program of the National Institute of Arthritis and Musculoskeletal and Skin Diseases (ZIG AR041181-11) to W.L.T. and M.G. European Union H2020 ERA project (No. 667824 – EXCELLtoINNOV) to M.V.Springer NatureRepositório da Universidade de LisboaClement, Cristina C.D’Alessandro, AngeloThangaswamy, SangeethaChalmers, SamanthaFurtado, RaquelSpada, SheilaMondanelli, GiadaIanni, FedericaGehrke, SarahGargaro, MarcoManni, GiorgiaCara, Luisa Carlota LopezRunge, PeterTsai, Wanxia LiKaraman, SinemArasa, JorgeFernandez-Rodriguez, RubenBeck, AmandaMacchiarulo, AntonioGadina, MassimoHalin, CorneliaFallarino, FrancescaSkobe, MihaelaVeldhoen, MarcMoretti, SimoneFormenti, SilviaDemaria, SandraSoni, Rajesh K.Galarini, RobertaSardella, RoccaldoLauvau, GregoirePutterman, ChaimAlitalo, KariGrohmann, UrsulaSantambrogio, Laura2021-07-29T14:36:03Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/49217engNat Commun. 2021 Jul 21;12(1):444710.1038/s41467-021-24785-32041-1723info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:52:43Zoai:repositorio.ul.pt:10451/49217Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:00:50.595664Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv 3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine
title 3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine
spellingShingle 3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine
Clement, Cristina C.
Autoimmunity
Inflammation
Skin diseases
title_short 3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine
title_full 3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine
title_fullStr 3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine
title_full_unstemmed 3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine
title_sort 3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine
author Clement, Cristina C.
author_facet Clement, Cristina C.
D’Alessandro, Angelo
Thangaswamy, Sangeetha
Chalmers, Samantha
Furtado, Raquel
Spada, Sheila
Mondanelli, Giada
Ianni, Federica
Gehrke, Sarah
Gargaro, Marco
Manni, Giorgia
Cara, Luisa Carlota Lopez
Runge, Peter
Tsai, Wanxia Li
Karaman, Sinem
Arasa, Jorge
Fernandez-Rodriguez, Ruben
Beck, Amanda
Macchiarulo, Antonio
Gadina, Massimo
Halin, Cornelia
Fallarino, Francesca
Skobe, Mihaela
Veldhoen, Marc
Moretti, Simone
Formenti, Silvia
Demaria, Sandra
Soni, Rajesh K.
Galarini, Roberta
Sardella, Roccaldo
Lauvau, Gregoire
Putterman, Chaim
Alitalo, Kari
Grohmann, Ursula
Santambrogio, Laura
author_role author
author2 D’Alessandro, Angelo
Thangaswamy, Sangeetha
Chalmers, Samantha
Furtado, Raquel
Spada, Sheila
Mondanelli, Giada
Ianni, Federica
Gehrke, Sarah
Gargaro, Marco
Manni, Giorgia
Cara, Luisa Carlota Lopez
Runge, Peter
Tsai, Wanxia Li
Karaman, Sinem
Arasa, Jorge
Fernandez-Rodriguez, Ruben
Beck, Amanda
Macchiarulo, Antonio
Gadina, Massimo
Halin, Cornelia
Fallarino, Francesca
Skobe, Mihaela
Veldhoen, Marc
Moretti, Simone
Formenti, Silvia
Demaria, Sandra
Soni, Rajesh K.
Galarini, Roberta
Sardella, Roccaldo
Lauvau, Gregoire
Putterman, Chaim
Alitalo, Kari
Grohmann, Ursula
Santambrogio, Laura
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
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dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Clement, Cristina C.
D’Alessandro, Angelo
Thangaswamy, Sangeetha
Chalmers, Samantha
Furtado, Raquel
Spada, Sheila
Mondanelli, Giada
Ianni, Federica
Gehrke, Sarah
Gargaro, Marco
Manni, Giorgia
Cara, Luisa Carlota Lopez
Runge, Peter
Tsai, Wanxia Li
Karaman, Sinem
Arasa, Jorge
Fernandez-Rodriguez, Ruben
Beck, Amanda
Macchiarulo, Antonio
Gadina, Massimo
Halin, Cornelia
Fallarino, Francesca
Skobe, Mihaela
Veldhoen, Marc
Moretti, Simone
Formenti, Silvia
Demaria, Sandra
Soni, Rajesh K.
Galarini, Roberta
Sardella, Roccaldo
Lauvau, Gregoire
Putterman, Chaim
Alitalo, Kari
Grohmann, Ursula
Santambrogio, Laura
dc.subject.por.fl_str_mv Autoimmunity
Inflammation
Skin diseases
topic Autoimmunity
Inflammation
Skin diseases
description © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
publishDate 2021
dc.date.none.fl_str_mv 2021-07-29T14:36:03Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/49217
url http://hdl.handle.net/10451/49217
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Nat Commun. 2021 Jul 21;12(1):4447
10.1038/s41467-021-24785-3
2041-1723
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dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
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