Optical coherence tomography angiography in exudative age-related macular degeneration

Detalhes bibliográficos
Autor(a) principal: Coscas, Florence
Data de Publicação: 2019
Outros Autores: Lupidi, Marco, Boulet, Jean François, Sellam, Alexandre, Cabral, Diogo, Serra, Rita, Français, Catherine, Souied, Eric H, Coscas, Gabriel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/60949
Resumo: © Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
id RCAP_13b96283e76e4ddbaa7cc4a4054a20a1
oai_identifier_str oai:run.unl.pt:10362/60949
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Optical coherence tomography angiography in exudative age-related macular degenerationa predictive model for treatment decisionsAMD, age-related macular degenerationchoroidal neovascularisationexudative-AMDOCT angiographyoptical coherence tomography angiographypredictive modelstructuralOCT© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.AIMS: To evaluate on optical coherence tomography angiography (OCT-A), the predictive role of different qualitative findings of choroidal neovascularisations (CNV) in assessing the status of exudative age-related macular degeneration (eAMD) and to develop a potential model to predict the CNV activity. METHODS: Retrospective review of the multimodal imaging records of patients with eAMD obtained during treatment for type 1 or type 2 CNV. The qualitative analysis of CNVs on OCT angiograms assessed the presence or absence of tiny branching vessels, loops, peripheral anastomotic arcades and choriocapillaris hypointense halo. These findings were then correlated with those of structural OCT scans. A score forecast was built and validated. RESULTS: One hundred and twenty-six eAMD eyes were enrolled in the study. Exudation was observed in 90 eyes (71%) on structural OCT. The qualitative OCT-A analysis revealed: tiny branching vessels in 82.5% of the cases, vascular loops in 81.7%, peripheral anastomotic arcades in 66.7% and choriocapillaris hypointense halo in 54.8%. In the univariate analysis, each OCT-A parameter showed a statistically significant correlation with exudation on structural OCT (p<0.001). The overall analysis demonstrated a sensitivity of 96.7% and a positive predictive value of 87.9%. In the multivariate analysis, a model with four criteria predicted an exudative lesion in 97.6% of cases and one with two criteria (tiny branching vessels and peripheral anastomotic arcades) in 71.2%. CONCLUSIONS: The presence of tiny branching vessels and a peripheral anastomotic arcade appears to predict the lesion activity with a good accuracy and the model based on four criteria enables optimal decisions regarding retreatment in eAMD.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNCoscas, FlorenceLupidi, MarcoBoulet, Jean FrançoisSellam, AlexandreCabral, DiogoSerra, RitaFrançais, CatherineSouied, Eric HCoscas, Gabriel2019-02-18T23:45:24Z2019-092019-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/60949eng0007-1161PURE: 11114868https://doi.org/10.1136/bjophthalmol-2018-313065info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:29:00Zoai:run.unl.pt:10362/60949Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:33:33.185128Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Optical coherence tomography angiography in exudative age-related macular degeneration
a predictive model for treatment decisions
title Optical coherence tomography angiography in exudative age-related macular degeneration
spellingShingle Optical coherence tomography angiography in exudative age-related macular degeneration
Coscas, Florence
AMD, age-related macular degeneration
choroidal neovascularisation
exudative-AMD
OCT angiography
optical coherence tomography angiography
predictive model
structuralOCT
title_short Optical coherence tomography angiography in exudative age-related macular degeneration
title_full Optical coherence tomography angiography in exudative age-related macular degeneration
title_fullStr Optical coherence tomography angiography in exudative age-related macular degeneration
title_full_unstemmed Optical coherence tomography angiography in exudative age-related macular degeneration
title_sort Optical coherence tomography angiography in exudative age-related macular degeneration
author Coscas, Florence
author_facet Coscas, Florence
Lupidi, Marco
Boulet, Jean François
Sellam, Alexandre
Cabral, Diogo
Serra, Rita
Français, Catherine
Souied, Eric H
Coscas, Gabriel
author_role author
author2 Lupidi, Marco
Boulet, Jean François
Sellam, Alexandre
Cabral, Diogo
Serra, Rita
Français, Catherine
Souied, Eric H
Coscas, Gabriel
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centro de Estudos de Doenças Crónicas (CEDOC)
RUN
dc.contributor.author.fl_str_mv Coscas, Florence
Lupidi, Marco
Boulet, Jean François
Sellam, Alexandre
Cabral, Diogo
Serra, Rita
Français, Catherine
Souied, Eric H
Coscas, Gabriel
dc.subject.por.fl_str_mv AMD, age-related macular degeneration
choroidal neovascularisation
exudative-AMD
OCT angiography
optical coherence tomography angiography
predictive model
structuralOCT
topic AMD, age-related macular degeneration
choroidal neovascularisation
exudative-AMD
OCT angiography
optical coherence tomography angiography
predictive model
structuralOCT
description © Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
publishDate 2019
dc.date.none.fl_str_mv 2019-02-18T23:45:24Z
2019-09
2019-09-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/60949
url http://hdl.handle.net/10362/60949
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0007-1161
PURE: 11114868
https://doi.org/10.1136/bjophthalmol-2018-313065
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799137957551013888

Registros relacionados