Nanogrooved microdiscs for bottom-up modulation of osteogenic differentiation

Detalhes bibliográficos
Autor(a) principal: Bjorge, Isabel M.
Data de Publicação: 2019
Outros Autores: Choi, Insung S., Correia, Clara R., Mano, João F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10773/28509
Resumo: Grooved topographical features have effectively modulated cell differentiation on two-dimensional substrates. To transpose patterning into a 3D environmment, nanogrooved microdiscs, "topodiscs", are produced as cell carriers for bottom-up cell-mediated assembly. While enhancing cell proliferation, topodiscs led to the formation of bone-like aggregates, even in culture medium lacking osteoinductive factors.
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spelling Nanogrooved microdiscs for bottom-up modulation of osteogenic differentiationCell DifferentiationOsteogenesisMicroparticlesTopographyBottom-upGrooved topographical features have effectively modulated cell differentiation on two-dimensional substrates. To transpose patterning into a 3D environmment, nanogrooved microdiscs, "topodiscs", are produced as cell carriers for bottom-up cell-mediated assembly. While enhancing cell proliferation, topodiscs led to the formation of bone-like aggregates, even in culture medium lacking osteoinductive factors.Royal Society of Chemistry2020-09-21T00:00:00Z2019-09-21T00:00:00Z2019-09-21info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/28509eng2040-336410.1039/c9nr06267jBjorge, Isabel M.Choi, Insung S.Correia, Clara R.Mano, João F.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:55:09Zoai:ria.ua.pt:10773/28509Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:01:02.031390Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Nanogrooved microdiscs for bottom-up modulation of osteogenic differentiation
title Nanogrooved microdiscs for bottom-up modulation of osteogenic differentiation
spellingShingle Nanogrooved microdiscs for bottom-up modulation of osteogenic differentiation
Bjorge, Isabel M.
Cell Differentiation
Osteogenesis
Microparticles
Topography
Bottom-up
title_short Nanogrooved microdiscs for bottom-up modulation of osteogenic differentiation
title_full Nanogrooved microdiscs for bottom-up modulation of osteogenic differentiation
title_fullStr Nanogrooved microdiscs for bottom-up modulation of osteogenic differentiation
title_full_unstemmed Nanogrooved microdiscs for bottom-up modulation of osteogenic differentiation
title_sort Nanogrooved microdiscs for bottom-up modulation of osteogenic differentiation
author Bjorge, Isabel M.
author_facet Bjorge, Isabel M.
Choi, Insung S.
Correia, Clara R.
Mano, João F.
author_role author
author2 Choi, Insung S.
Correia, Clara R.
Mano, João F.
author2_role author
author
author
dc.contributor.author.fl_str_mv Bjorge, Isabel M.
Choi, Insung S.
Correia, Clara R.
Mano, João F.
dc.subject.por.fl_str_mv Cell Differentiation
Osteogenesis
Microparticles
Topography
Bottom-up
topic Cell Differentiation
Osteogenesis
Microparticles
Topography
Bottom-up
description Grooved topographical features have effectively modulated cell differentiation on two-dimensional substrates. To transpose patterning into a 3D environmment, nanogrooved microdiscs, "topodiscs", are produced as cell carriers for bottom-up cell-mediated assembly. While enhancing cell proliferation, topodiscs led to the formation of bone-like aggregates, even in culture medium lacking osteoinductive factors.
publishDate 2019
dc.date.none.fl_str_mv 2019-09-21T00:00:00Z
2019-09-21
2020-09-21T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10773/28509
url http://hdl.handle.net/10773/28509
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2040-3364
10.1039/c9nr06267j
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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