Association of antioxidant monophenolic compounds with β-cyclodextrin-functionalized cellulose and starch substrates

• Autor(a) principal: Aguado, Roberto
• Data de Publicação: 2021
• Outros Autores: Murtinho, Dina, Valente, Artur J. M.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10316/107448; https://doi.org/10.1016/j.carbpol.2021.118189
• topic: Carbohydrate chemistry; Cellulose; Crosslinking; Phenolics; Release kinetics; Starch; β-Cyclodextrin; Acrolein; Antioxidants; Benzaldehydes; Butanes; Carboxylic Acids; Cellulose; Cross-Linking Reagents; Cymenes; Drug Liberation; Kinetics; Phenols; Phenylethyl Alcohol; Starch; beta-Cyclodextrins

Polysaccharide substrates loaded with antioxidant and antimicrobial compounds, effectively protected by cyclodextrin moieties, can be a long-lasting solution to confer certain properties to fabrics, paper and other materials. β-Cyclodextrin was attached to α-cellulose, bleached pulp and starch by a two-step esterification with a tetracarboxylic acid. The resulting derivatives were characterized by spectroscopy, thermal degradation analysis and capability of phenolphthalein inclusion. The carriers, containing between 89 and 171 μmol of β-cyclodextrin per gram, were loaded with carvacrol, cuminaldehyde, cinnamaldehyde and hydroxytyrosol. From a stoichiometric addition, the percentage of compound retained ranged from 49% (hydroxytyrosol in pulp-cyclodextrin) to 92% (carvacrol in starch-cyclodextrin). Finally, the release rate to aqueous ethanol was measured over eight days and fitted to kinetic models. From the analysis of the mean dissolution time, it can be concluded that inserting β-cyclodextrin units enhanced the long-term holding of phenolic active compounds in carbohydrate matrices.