Leprosy in wild chimpanzees
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/127179 |
Resumo: | UIDB/04038/2020 UIDP/04038/2020 FCT EXPL/IVC-ANT/0997/2013 IF/01128/2014 |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Leprosy in wild chimpanzeesUIDB/04038/2020 UIDP/04038/2020 FCT EXPL/IVC-ANT/0997/2013 IF/01128/2014Humans are considered as the main host for Mycobacterium leprae1, the aetiological agent of leprosy, but spillover has occurred to other mammals that are now maintenance hosts, such as nine-banded armadillos and red squirrels2,3. Although naturally acquired leprosy has also been described in captive nonhuman primates4–7, the exact origins of infection remain unclear. Here we describe leprosy-like lesions in two wild populations of western chimpanzees (Pan troglodytes verus) in Cantanhez National Park, Guinea-Bissau and Taï National Park, Côte d’Ivoire, West Africa. Longitudinal monitoring of both populations revealed the progression of disease symptoms compatible with advanced leprosy. Screening of faecal and necropsy samples confirmed the presence of M. leprae as the causative agent at each site and phylogenomic comparisons with other strains from humans and other animals show that the chimpanzee strains belong to different and rare genotypes (4N/O and 2F). These findings suggest that M. leprae may be circulating in more wild animals than suspected, either as a result of exposure to humans or other unknown environmental sources.Centro em Rede de Investigação em Antropologia (CRIA - NOVA FCSH)RUNHockings, Kimberley J.Mubemba, BenjaminAvanzi, CharlottePleh, KamillaDux, ArianeBersacola, ElenaBessa, JoanaRamon, MarinaMetzger, SonjaPatrono, Livia V.Jaffe, Jenny E.Benjak, AndrejBonneaud, CamilleBusso, PhilippeCouacy-Hymann, EmmanuelGado, MoussaGagneux, SebastienJohnson, Roch C.Kodio, MamoudouLynton-Jenkins, JoshuaMorozova, IrinaMatz-Rensing, KerstinRegalla, AissaSaid, Abilio R.Schuenemann, Verena J.Sow, Samba O.Spencer, John S.Ulrich, MarkusZoubi, HyacintheCole, Stewart T.Wittig, Roman M.Calvignac-Spencer, SebastienLeendertz, Fabian H.2021-11-04T23:38:24Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article6application/pdfhttp://hdl.handle.net/10362/127179eng0028-0836PURE: 34527223https://doi.org/10.1038/s41586-021-03968-4info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:07:15Zoai:run.unl.pt:10362/127179Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:46:03.694068Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Leprosy in wild chimpanzees |
| title |
Leprosy in wild chimpanzees |
| spellingShingle |
Leprosy in wild chimpanzees Hockings, Kimberley J. |
| title_short |
Leprosy in wild chimpanzees |
| title_full |
Leprosy in wild chimpanzees |
| title_fullStr |
Leprosy in wild chimpanzees |
| title_full_unstemmed |
Leprosy in wild chimpanzees |
| title_sort |
Leprosy in wild chimpanzees |
| author |
Hockings, Kimberley J. |
| author_facet |
Hockings, Kimberley J. Mubemba, Benjamin Avanzi, Charlotte Pleh, Kamilla Dux, Ariane Bersacola, Elena Bessa, Joana Ramon, Marina Metzger, Sonja Patrono, Livia V. Jaffe, Jenny E. Benjak, Andrej Bonneaud, Camille Busso, Philippe Couacy-Hymann, Emmanuel Gado, Moussa Gagneux, Sebastien Johnson, Roch C. Kodio, Mamoudou Lynton-Jenkins, Joshua Morozova, Irina Matz-Rensing, Kerstin Regalla, Aissa Said, Abilio R. Schuenemann, Verena J. Sow, Samba O. Spencer, John S. Ulrich, Markus Zoubi, Hyacinthe Cole, Stewart T. Wittig, Roman M. Calvignac-Spencer, Sebastien Leendertz, Fabian H. |
| author_role |
author |
| author2 |
Mubemba, Benjamin Avanzi, Charlotte Pleh, Kamilla Dux, Ariane Bersacola, Elena Bessa, Joana Ramon, Marina Metzger, Sonja Patrono, Livia V. Jaffe, Jenny E. Benjak, Andrej Bonneaud, Camille Busso, Philippe Couacy-Hymann, Emmanuel Gado, Moussa Gagneux, Sebastien Johnson, Roch C. Kodio, Mamoudou Lynton-Jenkins, Joshua Morozova, Irina Matz-Rensing, Kerstin Regalla, Aissa Said, Abilio R. Schuenemann, Verena J. Sow, Samba O. Spencer, John S. Ulrich, Markus Zoubi, Hyacinthe Cole, Stewart T. Wittig, Roman M. Calvignac-Spencer, Sebastien Leendertz, Fabian H. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Centro em Rede de Investigação em Antropologia (CRIA - NOVA FCSH) RUN |
| dc.contributor.author.fl_str_mv |
Hockings, Kimberley J. Mubemba, Benjamin Avanzi, Charlotte Pleh, Kamilla Dux, Ariane Bersacola, Elena Bessa, Joana Ramon, Marina Metzger, Sonja Patrono, Livia V. Jaffe, Jenny E. Benjak, Andrej Bonneaud, Camille Busso, Philippe Couacy-Hymann, Emmanuel Gado, Moussa Gagneux, Sebastien Johnson, Roch C. Kodio, Mamoudou Lynton-Jenkins, Joshua Morozova, Irina Matz-Rensing, Kerstin Regalla, Aissa Said, Abilio R. Schuenemann, Verena J. Sow, Samba O. Spencer, John S. Ulrich, Markus Zoubi, Hyacinthe Cole, Stewart T. Wittig, Roman M. Calvignac-Spencer, Sebastien Leendertz, Fabian H. |
| description |
UIDB/04038/2020 UIDP/04038/2020 FCT EXPL/IVC-ANT/0997/2013 IF/01128/2014 |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-11-04T23:38:24Z 2021 2021-01-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/127179 |
| url |
http://hdl.handle.net/10362/127179 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
0028-0836 PURE: 34527223 https://doi.org/10.1038/s41586-021-03968-4 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
6 application/pdf |
| dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
| instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| instacron_str |
RCAAP |
| institution |
RCAAP |
| reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799138064530931712 |