Infections After Liver Transplantation: A Retrospective, Single-Center Study
Autor(a) principal: | |
---|---|
Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.17/2294 |
Resumo: | Objective. To access the incidence of infectious problems after liver transplantation (LT). Design. A retrospective, single-center study. Materials and Methods. Patients undergoing LT from January 2008 to December 2011 were considered. Exclusion criterion was death occurring in the first 48 hours after LT. We determined the site of infection and the bacterial isolates and collected and compared recipient’s variables, graft variables, surgical data, post-LT clinical data. Results. Of the 492 patients who underwent LT and the 463 considered for this study, 190 (Group 1, 41%) developed at least 1 infection, with 298 infections detected. Of these, 189 microorganisms were isolated, 81 (51%) gram-positive bacteria (most frequently Staphylococcus spp). Biliary infections were more frequent (mean time of 160.4 167.7 days after LT); from 3 months after LT, gram-negative bacteria were observed (57%). Patients with infections after LT presented lower aminotransferase levels, but higher requirements in blood transfusions, intraoperative vasopressors, hemodialysis, and hospital stay. Operative and cold ischemia times were similar. Conclusion. We found a 41% incidence of all infections in a 2-year follow-up after LT. Gram-positive bacteria were more frequent isolated; however, negative bacteria were commonly isolated later. Clinical data after LT were more relevant for the development of infections. Donors’ variables should be considered in future analyses. |
id |
RCAP_148595da8ec6743acdb09f10ef903fbc |
---|---|
oai_identifier_str |
oai:repositorio.chlc.min-saude.pt:10400.17/2294 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Infections After Liver Transplantation: A Retrospective, Single-Center StudyBacterial Infections/epidemiologyBacterial Infections/etiologyHCC CHBPTIncidenceLiver Transplantation/adverse effectsPortugal/epidemiologyRetrospective StudiesTissue DonorsObjective. To access the incidence of infectious problems after liver transplantation (LT). Design. A retrospective, single-center study. Materials and Methods. Patients undergoing LT from January 2008 to December 2011 were considered. Exclusion criterion was death occurring in the first 48 hours after LT. We determined the site of infection and the bacterial isolates and collected and compared recipient’s variables, graft variables, surgical data, post-LT clinical data. Results. Of the 492 patients who underwent LT and the 463 considered for this study, 190 (Group 1, 41%) developed at least 1 infection, with 298 infections detected. Of these, 189 microorganisms were isolated, 81 (51%) gram-positive bacteria (most frequently Staphylococcus spp). Biliary infections were more frequent (mean time of 160.4 167.7 days after LT); from 3 months after LT, gram-negative bacteria were observed (57%). Patients with infections after LT presented lower aminotransferase levels, but higher requirements in blood transfusions, intraoperative vasopressors, hemodialysis, and hospital stay. Operative and cold ischemia times were similar. Conclusion. We found a 41% incidence of all infections in a 2-year follow-up after LT. Gram-positive bacteria were more frequent isolated; however, negative bacteria were commonly isolated later. Clinical data after LT were more relevant for the development of infections. Donors’ variables should be considered in future analyses.ElsevierRepositório do Centro Hospitalar Universitário de Lisboa Central, EPEAntunes, MTeixeira, AFortuna, PMoya, BMartins, ABagulho, LPereira, JPBento, LPerdigoto, RBarroso, EMarcelino, P2015-08-25T11:59:12Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/2294engTransplant Proc. 2015 May;47(4):1019-24info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:36:14Zoai:repositorio.chlc.min-saude.pt:10400.17/2294Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:19:39.710942Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Infections After Liver Transplantation: A Retrospective, Single-Center Study |
title |
Infections After Liver Transplantation: A Retrospective, Single-Center Study |
spellingShingle |
Infections After Liver Transplantation: A Retrospective, Single-Center Study Antunes, M Bacterial Infections/epidemiology Bacterial Infections/etiology HCC CHBPT Incidence Liver Transplantation/adverse effects Portugal/epidemiology Retrospective Studies Tissue Donors |
title_short |
Infections After Liver Transplantation: A Retrospective, Single-Center Study |
title_full |
Infections After Liver Transplantation: A Retrospective, Single-Center Study |
title_fullStr |
Infections After Liver Transplantation: A Retrospective, Single-Center Study |
title_full_unstemmed |
Infections After Liver Transplantation: A Retrospective, Single-Center Study |
title_sort |
Infections After Liver Transplantation: A Retrospective, Single-Center Study |
author |
Antunes, M |
author_facet |
Antunes, M Teixeira, A Fortuna, P Moya, B Martins, A Bagulho, L Pereira, JP Bento, L Perdigoto, R Barroso, E Marcelino, P |
author_role |
author |
author2 |
Teixeira, A Fortuna, P Moya, B Martins, A Bagulho, L Pereira, JP Bento, L Perdigoto, R Barroso, E Marcelino, P |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Antunes, M Teixeira, A Fortuna, P Moya, B Martins, A Bagulho, L Pereira, JP Bento, L Perdigoto, R Barroso, E Marcelino, P |
dc.subject.por.fl_str_mv |
Bacterial Infections/epidemiology Bacterial Infections/etiology HCC CHBPT Incidence Liver Transplantation/adverse effects Portugal/epidemiology Retrospective Studies Tissue Donors |
topic |
Bacterial Infections/epidemiology Bacterial Infections/etiology HCC CHBPT Incidence Liver Transplantation/adverse effects Portugal/epidemiology Retrospective Studies Tissue Donors |
description |
Objective. To access the incidence of infectious problems after liver transplantation (LT). Design. A retrospective, single-center study. Materials and Methods. Patients undergoing LT from January 2008 to December 2011 were considered. Exclusion criterion was death occurring in the first 48 hours after LT. We determined the site of infection and the bacterial isolates and collected and compared recipient’s variables, graft variables, surgical data, post-LT clinical data. Results. Of the 492 patients who underwent LT and the 463 considered for this study, 190 (Group 1, 41%) developed at least 1 infection, with 298 infections detected. Of these, 189 microorganisms were isolated, 81 (51%) gram-positive bacteria (most frequently Staphylococcus spp). Biliary infections were more frequent (mean time of 160.4 167.7 days after LT); from 3 months after LT, gram-negative bacteria were observed (57%). Patients with infections after LT presented lower aminotransferase levels, but higher requirements in blood transfusions, intraoperative vasopressors, hemodialysis, and hospital stay. Operative and cold ischemia times were similar. Conclusion. We found a 41% incidence of all infections in a 2-year follow-up after LT. Gram-positive bacteria were more frequent isolated; however, negative bacteria were commonly isolated later. Clinical data after LT were more relevant for the development of infections. Donors’ variables should be considered in future analyses. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-08-25T11:59:12Z 2015 2015-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/2294 |
url |
http://hdl.handle.net/10400.17/2294 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Transplant Proc. 2015 May;47(4):1019-24 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799131293692198912 |