Sentinel Node Total Tumour Load As a Predictive Factor for Non-Sentinel Node Status in Early Breast Cancer Patients – The porttle study

Detalhes bibliográficos
Autor(a) principal: Fougo, JL
Data de Publicação: 2020
Outros Autores: Amendoeira, I, Brito, MJ, Correia, AP, Gonçalves, A, Honavar, M, Machado, A, Magalhães, A, Marta, S, Nogueira, M, Peleteiro, B, Pontes, P
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.17/4725
Resumo: OSNA is a molecular assay for the detection of sentinel node metastasis. TTL emerged as a concept that seems to accurately predict the status of the NSN. Authors tried to confirm this motion. This is a retrospective and multicentric study that analyzed 2164 patients, 579 of whom had positive SN and completion AD. Logistic regression models were performed in order to identify a suitable cutoff to identify patients who benefit from AD. Univariate and multivariate regression analysis showed a relationship between TTL>30000 and the presence of NSN metastasis (OR 2.84, CI 1.99-4.08, p < 0.001). Logistic regression indicated that the cutoff of 30000 copies/μL better discriminates patients with NSN positivity and allows wide use of these criteria. This cutoff value may safely assist clinicians and patients to decide to proceed or not with an AD.
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spelling Sentinel Node Total Tumour Load As a Predictive Factor for Non-Sentinel Node Status in Early Breast Cancer Patients – The porttle studyHCC CIRAdultAgedBreast Neoplasms / metabolismAged, 80 and overBreast Neoplasms / pathology*HumansFemaleBreast Neoplasms / surgeryMiddle AgedCarcinoma, Ductal, Breast / metabolismCarcinoma, Ductal, Breast / secondary*Carcinoma, Ductal, Breast / surgeryCarcinoma, Lobular / metabolismCarcinoma, Lobular / secondary*Carcinoma, Lobular / surgeryFollow-Up StudiesLymph Nodes / metabolismLymph Nodes / pathology*Lymph Nodes / surgeryLymphatic MetastasisPrognosisReceptor, ErbB-2 / metabolismReceptors, Estrogen / metabolismReceptors, Progesterone / metabolismYoung AdultSentinel Lymph Node Biopsy*Retrospective StudiesOSNA is a molecular assay for the detection of sentinel node metastasis. TTL emerged as a concept that seems to accurately predict the status of the NSN. Authors tried to confirm this motion. This is a retrospective and multicentric study that analyzed 2164 patients, 579 of whom had positive SN and completion AD. Logistic regression models were performed in order to identify a suitable cutoff to identify patients who benefit from AD. Univariate and multivariate regression analysis showed a relationship between TTL>30000 and the presence of NSN metastasis (OR 2.84, CI 1.99-4.08, p < 0.001). Logistic regression indicated that the cutoff of 30000 copies/μL better discriminates patients with NSN positivity and allows wide use of these criteria. This cutoff value may safely assist clinicians and patients to decide to proceed or not with an AD.ElsevierRepositório do Centro Hospitalar Universitário de Lisboa Central, EPEFougo, JLAmendoeira, IBrito, MJCorreia, APGonçalves, AHonavar, MMachado, AMagalhães, AMarta, SNogueira, MPeleteiro, BPontes, P2023-11-02T15:24:58Z2020-032020-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/4725engSurg Oncol . 2020 Mar:32:108-114.10.1016/j.suronc.2019.11.008info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-05T06:33:11Zoai:repositorio.chlc.min-saude.pt:10400.17/4725Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:26:49.699177Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Sentinel Node Total Tumour Load As a Predictive Factor for Non-Sentinel Node Status in Early Breast Cancer Patients – The porttle study
title Sentinel Node Total Tumour Load As a Predictive Factor for Non-Sentinel Node Status in Early Breast Cancer Patients – The porttle study
spellingShingle Sentinel Node Total Tumour Load As a Predictive Factor for Non-Sentinel Node Status in Early Breast Cancer Patients – The porttle study
Fougo, JL
HCC CIR
Adult
Aged
Breast Neoplasms / metabolism
Aged, 80 and over
Breast Neoplasms / pathology*
Humans
Female
Breast Neoplasms / surgery
Middle Aged
Carcinoma, Ductal, Breast / metabolism
Carcinoma, Ductal, Breast / secondary*
Carcinoma, Ductal, Breast / surgery
Carcinoma, Lobular / metabolism
Carcinoma, Lobular / secondary*
Carcinoma, Lobular / surgery
Follow-Up Studies
Lymph Nodes / metabolism
Lymph Nodes / pathology*
Lymph Nodes / surgery
Lymphatic Metastasis
Prognosis
Receptor, ErbB-2 / metabolism
Receptors, Estrogen / metabolism
Receptors, Progesterone / metabolism
Young Adult
Sentinel Lymph Node Biopsy*
Retrospective Studies
title_short Sentinel Node Total Tumour Load As a Predictive Factor for Non-Sentinel Node Status in Early Breast Cancer Patients – The porttle study
title_full Sentinel Node Total Tumour Load As a Predictive Factor for Non-Sentinel Node Status in Early Breast Cancer Patients – The porttle study
title_fullStr Sentinel Node Total Tumour Load As a Predictive Factor for Non-Sentinel Node Status in Early Breast Cancer Patients – The porttle study
title_full_unstemmed Sentinel Node Total Tumour Load As a Predictive Factor for Non-Sentinel Node Status in Early Breast Cancer Patients – The porttle study
title_sort Sentinel Node Total Tumour Load As a Predictive Factor for Non-Sentinel Node Status in Early Breast Cancer Patients – The porttle study
author Fougo, JL
author_facet Fougo, JL
Amendoeira, I
Brito, MJ
Correia, AP
Gonçalves, A
Honavar, M
Machado, A
Magalhães, A
Marta, S
Nogueira, M
Peleteiro, B
Pontes, P
author_role author
author2 Amendoeira, I
Brito, MJ
Correia, AP
Gonçalves, A
Honavar, M
Machado, A
Magalhães, A
Marta, S
Nogueira, M
Peleteiro, B
Pontes, P
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE
dc.contributor.author.fl_str_mv Fougo, JL
Amendoeira, I
Brito, MJ
Correia, AP
Gonçalves, A
Honavar, M
Machado, A
Magalhães, A
Marta, S
Nogueira, M
Peleteiro, B
Pontes, P
dc.subject.por.fl_str_mv HCC CIR
Adult
Aged
Breast Neoplasms / metabolism
Aged, 80 and over
Breast Neoplasms / pathology*
Humans
Female
Breast Neoplasms / surgery
Middle Aged
Carcinoma, Ductal, Breast / metabolism
Carcinoma, Ductal, Breast / secondary*
Carcinoma, Ductal, Breast / surgery
Carcinoma, Lobular / metabolism
Carcinoma, Lobular / secondary*
Carcinoma, Lobular / surgery
Follow-Up Studies
Lymph Nodes / metabolism
Lymph Nodes / pathology*
Lymph Nodes / surgery
Lymphatic Metastasis
Prognosis
Receptor, ErbB-2 / metabolism
Receptors, Estrogen / metabolism
Receptors, Progesterone / metabolism
Young Adult
Sentinel Lymph Node Biopsy*
Retrospective Studies
topic HCC CIR
Adult
Aged
Breast Neoplasms / metabolism
Aged, 80 and over
Breast Neoplasms / pathology*
Humans
Female
Breast Neoplasms / surgery
Middle Aged
Carcinoma, Ductal, Breast / metabolism
Carcinoma, Ductal, Breast / secondary*
Carcinoma, Ductal, Breast / surgery
Carcinoma, Lobular / metabolism
Carcinoma, Lobular / secondary*
Carcinoma, Lobular / surgery
Follow-Up Studies
Lymph Nodes / metabolism
Lymph Nodes / pathology*
Lymph Nodes / surgery
Lymphatic Metastasis
Prognosis
Receptor, ErbB-2 / metabolism
Receptors, Estrogen / metabolism
Receptors, Progesterone / metabolism
Young Adult
Sentinel Lymph Node Biopsy*
Retrospective Studies
description OSNA is a molecular assay for the detection of sentinel node metastasis. TTL emerged as a concept that seems to accurately predict the status of the NSN. Authors tried to confirm this motion. This is a retrospective and multicentric study that analyzed 2164 patients, 579 of whom had positive SN and completion AD. Logistic regression models were performed in order to identify a suitable cutoff to identify patients who benefit from AD. Univariate and multivariate regression analysis showed a relationship between TTL>30000 and the presence of NSN metastasis (OR 2.84, CI 1.99-4.08, p < 0.001). Logistic regression indicated that the cutoff of 30000 copies/μL better discriminates patients with NSN positivity and allows wide use of these criteria. This cutoff value may safely assist clinicians and patients to decide to proceed or not with an AD.
publishDate 2020
dc.date.none.fl_str_mv 2020-03
2020-03-01T00:00:00Z
2023-11-02T15:24:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.17/4725
url http://hdl.handle.net/10400.17/4725
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Surg Oncol . 2020 Mar:32:108-114.
10.1016/j.suronc.2019.11.008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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