Systemic markers of the redox balance and Apolipoprotein E Polymorphism in Atherosclerosis: the Relevance for an Integrated Study
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2006 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.3/2742 |
Resumo: | Copyright © 2006 by Humana Press Inc. |
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Systemic markers of the redox balance and Apolipoprotein E Polymorphism in Atherosclerosis: the Relevance for an Integrated StudyAtherosclerosisAntioxidant DefensesOxidative DamageTrace ElementsApolipoprotein ECopyright © 2006 by Humana Press Inc.Artigo original publicado por Humana Press Inc. Actual Editora da Revista Biological Trace Element Research: Springer [A publicação original está disponível em www.springerlink.com].Prospective studies have demonstrated that an imbalance between oxidative damage and antioxidative protection can play a role in the development and progression of atherosclerosis. Also, genotypes with the apolipoprotein E ζ4 allele have been associated with an increase risk for this pathology. Based on this knowledge, the aim of this study was to evaluate indicators of the redox balance, trace elements, and apolipoprotein E allelic profile in subjects from the Lisbon population with clinically stable atherosclerosis, at risk for atherosclerotic events, and in healthy subjects for comparison. The activities of superoxide dismutase in erythrocytes and glutathione peroxidase in whole blood, plasma total thiols, and serum ceruloplasmin were kept unchanged among the three groups. Serum α-tocopherol was increased in atherosclerotic patients. Total malondialdehyde in serum and protein carbonyls in plasma, which are indicators of lipid and protein oxidative damage, respectively, reached their highest values in risk subjects. The concentrations of potassium and calcium, in plasma and in blood cells, were slightly elevated in patients and might reflect an electrolytic imbalance. Regarding the apolipoprotein E polymorphism, atherosclerotic patients had an increased incidence of the high-risk genotypes for atherogenesis (ζ3/ζ4 and ζ4/ζ4). A multivariate model applied to the general population using most of the parameters clearly separated the three groups at study (i.e., the healthy group from the steady-state group of risk disease and from the atherosclerotic one). As shown by us, the usefulness of biochemical and complementary genetic markers is warranted for a better knowledge on atherosclerosis molecular basis.Fundação para a Ciência e a Tecnologia; Centro de Biologia Ambiental; Instituto de Investigação Científica Bento da Rocha Cabral; Instituto Nacional de Saúde Dr. Ricardo Jorge.Humana Press Inc.Repositório da Universidade dos AçoresLopes, Paula AlexandraNapoleão, PatríciaPinheiro, TeresaCeia, FátimaSteghens, Jean-PaulPavão, Maria LeonorSantos, Maria CristinaViegas-Crespo, Ana Maria2014-02-11T11:55:01Z20062006-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.3/2742engLOPES, P. A., NAPOLEÃO, P., PINHEIRO, T., CEIA, F., STEGHENS, J. P., PAVÃO, M. L., SANTOS, M. C. e VIEGAS-CRESPO, A. M. (2006). "Systemic markers of the redox balance and Apolipoprotein E Polymorphism in Atherosclerosis: the Relevance for an Integrated Study". Biological Trace Element Research, 112(1): 57-75. http://dx.doi.org/10.1385/BTER:112:1:57.1559-0720 (Online)info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-12-20T14:30:36Zoai:repositorio.uac.pt:10400.3/2742Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:25:24.161175Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Systemic markers of the redox balance and Apolipoprotein E Polymorphism in Atherosclerosis: the Relevance for an Integrated Study |
| title |
Systemic markers of the redox balance and Apolipoprotein E Polymorphism in Atherosclerosis: the Relevance for an Integrated Study |
| spellingShingle |
Systemic markers of the redox balance and Apolipoprotein E Polymorphism in Atherosclerosis: the Relevance for an Integrated Study Lopes, Paula Alexandra Atherosclerosis Antioxidant Defenses Oxidative Damage Trace Elements Apolipoprotein E |
| title_short |
Systemic markers of the redox balance and Apolipoprotein E Polymorphism in Atherosclerosis: the Relevance for an Integrated Study |
| title_full |
Systemic markers of the redox balance and Apolipoprotein E Polymorphism in Atherosclerosis: the Relevance for an Integrated Study |
| title_fullStr |
Systemic markers of the redox balance and Apolipoprotein E Polymorphism in Atherosclerosis: the Relevance for an Integrated Study |
| title_full_unstemmed |
Systemic markers of the redox balance and Apolipoprotein E Polymorphism in Atherosclerosis: the Relevance for an Integrated Study |
| title_sort |
Systemic markers of the redox balance and Apolipoprotein E Polymorphism in Atherosclerosis: the Relevance for an Integrated Study |
| author |
Lopes, Paula Alexandra |
| author_facet |
Lopes, Paula Alexandra Napoleão, Patrícia Pinheiro, Teresa Ceia, Fátima Steghens, Jean-Paul Pavão, Maria Leonor Santos, Maria Cristina Viegas-Crespo, Ana Maria |
| author_role |
author |
| author2 |
Napoleão, Patrícia Pinheiro, Teresa Ceia, Fátima Steghens, Jean-Paul Pavão, Maria Leonor Santos, Maria Cristina Viegas-Crespo, Ana Maria |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade dos Açores |
| dc.contributor.author.fl_str_mv |
Lopes, Paula Alexandra Napoleão, Patrícia Pinheiro, Teresa Ceia, Fátima Steghens, Jean-Paul Pavão, Maria Leonor Santos, Maria Cristina Viegas-Crespo, Ana Maria |
| dc.subject.por.fl_str_mv |
Atherosclerosis Antioxidant Defenses Oxidative Damage Trace Elements Apolipoprotein E |
| topic |
Atherosclerosis Antioxidant Defenses Oxidative Damage Trace Elements Apolipoprotein E |
| description |
Copyright © 2006 by Humana Press Inc. |
| publishDate |
2006 |
| dc.date.none.fl_str_mv |
2006 2006-01-01T00:00:00Z 2014-02-11T11:55:01Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.3/2742 |
| url |
http://hdl.handle.net/10400.3/2742 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
LOPES, P. A., NAPOLEÃO, P., PINHEIRO, T., CEIA, F., STEGHENS, J. P., PAVÃO, M. L., SANTOS, M. C. e VIEGAS-CRESPO, A. M. (2006). "Systemic markers of the redox balance and Apolipoprotein E Polymorphism in Atherosclerosis: the Relevance for an Integrated Study". Biological Trace Element Research, 112(1): 57-75. http://dx.doi.org/10.1385/BTER:112:1:57. 1559-0720 (Online) |
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info:eu-repo/semantics/openAccess |
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openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Humana Press Inc. |
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Humana Press Inc. |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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