Nonequilibrium model for estimating parameters of deleterious mutations

Detalhes bibliográficos
Autor(a) principal: Gordo, I.
Data de Publicação: 2005
Outros Autores: Dionisio, F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/91
Resumo: Deleterious mutations are of extreme evolutionary importance because, even though they are eliminated by natural selection, their continuous pressure creates a pool of variability in natural populations. They are of potential relevance for the existence of several features in evolution, such as sexual reproduction, and pose a risk to small asexual populations. Despite their extreme importance, the deleterious mutation rate and the effects of each mutation on fitness are poorly known quantities. Here we analyze a simple model that can be applied to simple experiments, in microorganisms, aiming at the quantification of these values.
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spelling Nonequilibrium model for estimating parameters of deleterious mutationsEvolutionGenetic Variation/geneticsGenetics, Population/methodsModels, GeneticMutation/geneticsPopulation DynamicsSelection, GeneticDeleterious mutations are of extreme evolutionary importance because, even though they are eliminated by natural selection, their continuous pressure creates a pool of variability in natural populations. They are of potential relevance for the existence of several features in evolution, such as sexual reproduction, and pose a risk to small asexual populations. Despite their extreme importance, the deleterious mutation rate and the effects of each mutation on fitness are poorly known quantities. Here we analyze a simple model that can be applied to simple experiments, in microorganisms, aiming at the quantification of these values.American Physical SocietyARCAGordo, I.Dionisio, F.2010-03-25T16:03:24Z2005-03-182005-03-18T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/91engISSN: 1539-375510.1103/PhysRevE.71.031907info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-21T14:19:09Zoai:arca.igc.gulbenkian.pt:10400.7/91Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-21T14:19:09Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Nonequilibrium model for estimating parameters of deleterious mutations
title Nonequilibrium model for estimating parameters of deleterious mutations
spellingShingle Nonequilibrium model for estimating parameters of deleterious mutations
Gordo, I.
Evolution
Genetic Variation/genetics
Genetics, Population/methods
Models, Genetic
Mutation/genetics
Population Dynamics
Selection, Genetic
title_short Nonequilibrium model for estimating parameters of deleterious mutations
title_full Nonequilibrium model for estimating parameters of deleterious mutations
title_fullStr Nonequilibrium model for estimating parameters of deleterious mutations
title_full_unstemmed Nonequilibrium model for estimating parameters of deleterious mutations
title_sort Nonequilibrium model for estimating parameters of deleterious mutations
author Gordo, I.
author_facet Gordo, I.
Dionisio, F.
author_role author
author2 Dionisio, F.
author2_role author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Gordo, I.
Dionisio, F.
dc.subject.por.fl_str_mv Evolution
Genetic Variation/genetics
Genetics, Population/methods
Models, Genetic
Mutation/genetics
Population Dynamics
Selection, Genetic
topic Evolution
Genetic Variation/genetics
Genetics, Population/methods
Models, Genetic
Mutation/genetics
Population Dynamics
Selection, Genetic
description Deleterious mutations are of extreme evolutionary importance because, even though they are eliminated by natural selection, their continuous pressure creates a pool of variability in natural populations. They are of potential relevance for the existence of several features in evolution, such as sexual reproduction, and pose a risk to small asexual populations. Despite their extreme importance, the deleterious mutation rate and the effects of each mutation on fitness are poorly known quantities. Here we analyze a simple model that can be applied to simple experiments, in microorganisms, aiming at the quantification of these values.
publishDate 2005
dc.date.none.fl_str_mv 2005-03-18
2005-03-18T00:00:00Z
2010-03-25T16:03:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/91
url http://hdl.handle.net/10400.7/91
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv ISSN: 1539-3755
10.1103/PhysRevE.71.031907
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Physical Society
publisher.none.fl_str_mv American Physical Society
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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