Biological Thermal Performance of Organic and Inorganic Aerogels as Patches for Photothermal Therapy
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/150796 |
Resumo: | Funding Information: The authors would like to thank to Fundação para a Ciência e a Tecnologia (FCT) for the essential financial support under project reference UIDB/EQU/00102/2020, and to MICINN [PID2020-120010RB-I00], Agencia Estatal de Investigación [AEI] and FEDER funds. A.I.-M. also acknowledges to Xunta de Galicia for her predoctoral research fellowship [ED481A-2020/104]. Funding Information: This work was performed within the frame of a Short-Term Scientific Mission from COST Action “Advanced Engineering of AeroGels for Environment and Life Sciences” (AERoGELS, ref. CA18125), supported by the COST (European Cooperation in Science and Technology). Moreover, the authors are also grateful to Manuel Fitas from the PhDTrials, Lda for his support. The authors also acknowledge Nuno Costa for its support during DSC analysis and TripleBlue-Pharma Consulting, Lda. ( info@tripleblue.pt ) for revising and editing the manuscript in order to meet English standards. Lastly, the authors are grateful to Carlos Pinheiro, for human skin ex vivo grafts. ® Publisher Copyright: © 2022 by the authors. |
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Biological Thermal Performance of Organic and Inorganic Aerogels as Patches for Photothermal Therapylight delimiterspectin aerogelssilica aerogelsBioengineeringBiomaterialsOrganic ChemistryPolymers and PlasticsSDG 3 - Good Health and Well-beingFunding Information: The authors would like to thank to Fundação para a Ciência e a Tecnologia (FCT) for the essential financial support under project reference UIDB/EQU/00102/2020, and to MICINN [PID2020-120010RB-I00], Agencia Estatal de Investigación [AEI] and FEDER funds. A.I.-M. also acknowledges to Xunta de Galicia for her predoctoral research fellowship [ED481A-2020/104]. Funding Information: This work was performed within the frame of a Short-Term Scientific Mission from COST Action “Advanced Engineering of AeroGels for Environment and Life Sciences” (AERoGELS, ref. CA18125), supported by the COST (European Cooperation in Science and Technology). Moreover, the authors are also grateful to Manuel Fitas from the PhDTrials, Lda for his support. The authors also acknowledge Nuno Costa for its support during DSC analysis and TripleBlue-Pharma Consulting, Lda. ( info@tripleblue.pt ) for revising and editing the manuscript in order to meet English standards. Lastly, the authors are grateful to Carlos Pinheiro, for human skin ex vivo grafts. ® Publisher Copyright: © 2022 by the authors.Aerogels are materials with unique properties, among which are low density and thermal conductivity. They are also known for their exquisite biocompatibility and biodegradability. All these features make them attractive for biomedical applications, such as their potential use in photothermal therapy (PTT). This technique is, yet, still associated with undesirable effects on surrounding tissues which emphasizes the need to minimize the exposure of healthy regions. One way to do so relies on the use of materials able to block the radiation and the heat generated. Aerogels might be potentially useful for this purpose by acting as insulators. Silica- and pectin-based aerogels are reported as the best inorganic and organic thermal insulators, respectively; thus, the aim of this work relies on assessing the possibility of using these materials as light and thermal insulators and delimiters for PTT. Silica- and pectin-based aerogels were prepared and fully characterized. The thermal protection efficacy of the aerogels when irradiated with a near-infrared laser was assessed using phantoms and ex vivo grafts. Lastly, safety was assessed in human volunteers. Both types presented good textural properties and safe profiles. Moreover, thermal activation unveils the better performance of silica-based aerogels, confirming the potential of this material for PTT.DF – Departamento de FísicaRUNFerreira-Gonçalves, TâniaIglesias-Mejuto, AnaLinhares, TeresaCoelho, João M. P.Vieira, PedroFaísca, PedroCatarino, JoséPinto, PedroFerreira, DavidFerreira, Hugo A.Gaspar, Maria ManuelaDurães, LuísaGarcía-González, Carlos A.Reis, Catarina Pinto2023-03-17T22:30:49Z2022-08-032022-08-03T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article18application/pdfhttp://hdl.handle.net/10362/150796eng2310-2861PURE: 56162529https://doi.org/10.3390/gels8080485info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:33:13Zoai:run.unl.pt:10362/150796Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:54:19.413160Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Biological Thermal Performance of Organic and Inorganic Aerogels as Patches for Photothermal Therapy |
title |
Biological Thermal Performance of Organic and Inorganic Aerogels as Patches for Photothermal Therapy |
spellingShingle |
Biological Thermal Performance of Organic and Inorganic Aerogels as Patches for Photothermal Therapy Ferreira-Gonçalves, Tânia light delimiters pectin aerogels silica aerogels Bioengineering Biomaterials Organic Chemistry Polymers and Plastics SDG 3 - Good Health and Well-being |
title_short |
Biological Thermal Performance of Organic and Inorganic Aerogels as Patches for Photothermal Therapy |
title_full |
Biological Thermal Performance of Organic and Inorganic Aerogels as Patches for Photothermal Therapy |
title_fullStr |
Biological Thermal Performance of Organic and Inorganic Aerogels as Patches for Photothermal Therapy |
title_full_unstemmed |
Biological Thermal Performance of Organic and Inorganic Aerogels as Patches for Photothermal Therapy |
title_sort |
Biological Thermal Performance of Organic and Inorganic Aerogels as Patches for Photothermal Therapy |
author |
Ferreira-Gonçalves, Tânia |
author_facet |
Ferreira-Gonçalves, Tânia Iglesias-Mejuto, Ana Linhares, Teresa Coelho, João M. P. Vieira, Pedro Faísca, Pedro Catarino, José Pinto, Pedro Ferreira, David Ferreira, Hugo A. Gaspar, Maria Manuela Durães, Luísa García-González, Carlos A. Reis, Catarina Pinto |
author_role |
author |
author2 |
Iglesias-Mejuto, Ana Linhares, Teresa Coelho, João M. P. Vieira, Pedro Faísca, Pedro Catarino, José Pinto, Pedro Ferreira, David Ferreira, Hugo A. Gaspar, Maria Manuela Durães, Luísa García-González, Carlos A. Reis, Catarina Pinto |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
DF – Departamento de Física RUN |
dc.contributor.author.fl_str_mv |
Ferreira-Gonçalves, Tânia Iglesias-Mejuto, Ana Linhares, Teresa Coelho, João M. P. Vieira, Pedro Faísca, Pedro Catarino, José Pinto, Pedro Ferreira, David Ferreira, Hugo A. Gaspar, Maria Manuela Durães, Luísa García-González, Carlos A. Reis, Catarina Pinto |
dc.subject.por.fl_str_mv |
light delimiters pectin aerogels silica aerogels Bioengineering Biomaterials Organic Chemistry Polymers and Plastics SDG 3 - Good Health and Well-being |
topic |
light delimiters pectin aerogels silica aerogels Bioengineering Biomaterials Organic Chemistry Polymers and Plastics SDG 3 - Good Health and Well-being |
description |
Funding Information: The authors would like to thank to Fundação para a Ciência e a Tecnologia (FCT) for the essential financial support under project reference UIDB/EQU/00102/2020, and to MICINN [PID2020-120010RB-I00], Agencia Estatal de Investigación [AEI] and FEDER funds. A.I.-M. also acknowledges to Xunta de Galicia for her predoctoral research fellowship [ED481A-2020/104]. Funding Information: This work was performed within the frame of a Short-Term Scientific Mission from COST Action “Advanced Engineering of AeroGels for Environment and Life Sciences” (AERoGELS, ref. CA18125), supported by the COST (European Cooperation in Science and Technology). Moreover, the authors are also grateful to Manuel Fitas from the PhDTrials, Lda for his support. The authors also acknowledge Nuno Costa for its support during DSC analysis and TripleBlue-Pharma Consulting, Lda. ( info@tripleblue.pt ) for revising and editing the manuscript in order to meet English standards. Lastly, the authors are grateful to Carlos Pinheiro, for human skin ex vivo grafts. ® Publisher Copyright: © 2022 by the authors. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-08-03 2022-08-03T00:00:00Z 2023-03-17T22:30:49Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/150796 |
url |
http://hdl.handle.net/10362/150796 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2310-2861 PURE: 56162529 https://doi.org/10.3390/gels8080485 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
18 application/pdf |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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