Biological Thermal Performance of Organic and Inorganic Aerogels as Patches for Photothermal Therapy

Detalhes bibliográficos
Autor(a) principal: Ferreira-Gonçalves, Tânia
Data de Publicação: 2022
Outros Autores: Iglesias-Mejuto, Ana, Linhares, Teresa, Coelho, João M. P., Vieira, Pedro, Faísca, Pedro, Catarino, José, Pinto, Pedro, Ferreira, David, Ferreira, Hugo A., Gaspar, Maria Manuela, Durães, Luísa, García-González, Carlos A., Reis, Catarina Pinto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/150796
Resumo: Funding Information: The authors would like to thank to Fundação para a Ciência e a Tecnologia (FCT) for the essential financial support under project reference UIDB/EQU/00102/2020, and to MICINN [PID2020-120010RB-I00], Agencia Estatal de Investigación [AEI] and FEDER funds. A.I.-M. also acknowledges to Xunta de Galicia for her predoctoral research fellowship [ED481A-2020/104]. Funding Information: This work was performed within the frame of a Short-Term Scientific Mission from COST Action “Advanced Engineering of AeroGels for Environment and Life Sciences” (AERoGELS, ref. CA18125), supported by the COST (European Cooperation in Science and Technology). Moreover, the authors are also grateful to Manuel Fitas from the PhDTrials, Lda for his support. The authors also acknowledge Nuno Costa for its support during DSC analysis and TripleBlue-Pharma Consulting, Lda. ( info@tripleblue.pt ) for revising and editing the manuscript in order to meet English standards. Lastly, the authors are grateful to Carlos Pinheiro, for human skin ex vivo grafts. ® Publisher Copyright: © 2022 by the authors.
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spelling Biological Thermal Performance of Organic and Inorganic Aerogels as Patches for Photothermal Therapylight delimiterspectin aerogelssilica aerogelsBioengineeringBiomaterialsOrganic ChemistryPolymers and PlasticsSDG 3 - Good Health and Well-beingFunding Information: The authors would like to thank to Fundação para a Ciência e a Tecnologia (FCT) for the essential financial support under project reference UIDB/EQU/00102/2020, and to MICINN [PID2020-120010RB-I00], Agencia Estatal de Investigación [AEI] and FEDER funds. A.I.-M. also acknowledges to Xunta de Galicia for her predoctoral research fellowship [ED481A-2020/104]. Funding Information: This work was performed within the frame of a Short-Term Scientific Mission from COST Action “Advanced Engineering of AeroGels for Environment and Life Sciences” (AERoGELS, ref. CA18125), supported by the COST (European Cooperation in Science and Technology). Moreover, the authors are also grateful to Manuel Fitas from the PhDTrials, Lda for his support. The authors also acknowledge Nuno Costa for its support during DSC analysis and TripleBlue-Pharma Consulting, Lda. ( info@tripleblue.pt ) for revising and editing the manuscript in order to meet English standards. Lastly, the authors are grateful to Carlos Pinheiro, for human skin ex vivo grafts. ® Publisher Copyright: © 2022 by the authors.Aerogels are materials with unique properties, among which are low density and thermal conductivity. They are also known for their exquisite biocompatibility and biodegradability. All these features make them attractive for biomedical applications, such as their potential use in photothermal therapy (PTT). This technique is, yet, still associated with undesirable effects on surrounding tissues which emphasizes the need to minimize the exposure of healthy regions. One way to do so relies on the use of materials able to block the radiation and the heat generated. Aerogels might be potentially useful for this purpose by acting as insulators. Silica- and pectin-based aerogels are reported as the best inorganic and organic thermal insulators, respectively; thus, the aim of this work relies on assessing the possibility of using these materials as light and thermal insulators and delimiters for PTT. Silica- and pectin-based aerogels were prepared and fully characterized. The thermal protection efficacy of the aerogels when irradiated with a near-infrared laser was assessed using phantoms and ex vivo grafts. Lastly, safety was assessed in human volunteers. Both types presented good textural properties and safe profiles. Moreover, thermal activation unveils the better performance of silica-based aerogels, confirming the potential of this material for PTT.DF – Departamento de FísicaRUNFerreira-Gonçalves, TâniaIglesias-Mejuto, AnaLinhares, TeresaCoelho, João M. P.Vieira, PedroFaísca, PedroCatarino, JoséPinto, PedroFerreira, DavidFerreira, Hugo A.Gaspar, Maria ManuelaDurães, LuísaGarcía-González, Carlos A.Reis, Catarina Pinto2023-03-17T22:30:49Z2022-08-032022-08-03T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article18application/pdfhttp://hdl.handle.net/10362/150796eng2310-2861PURE: 56162529https://doi.org/10.3390/gels8080485info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:33:13Zoai:run.unl.pt:10362/150796Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:54:19.413160Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Biological Thermal Performance of Organic and Inorganic Aerogels as Patches for Photothermal Therapy
title Biological Thermal Performance of Organic and Inorganic Aerogels as Patches for Photothermal Therapy
spellingShingle Biological Thermal Performance of Organic and Inorganic Aerogels as Patches for Photothermal Therapy
Ferreira-Gonçalves, Tânia
light delimiters
pectin aerogels
silica aerogels
Bioengineering
Biomaterials
Organic Chemistry
Polymers and Plastics
SDG 3 - Good Health and Well-being
title_short Biological Thermal Performance of Organic and Inorganic Aerogels as Patches for Photothermal Therapy
title_full Biological Thermal Performance of Organic and Inorganic Aerogels as Patches for Photothermal Therapy
title_fullStr Biological Thermal Performance of Organic and Inorganic Aerogels as Patches for Photothermal Therapy
title_full_unstemmed Biological Thermal Performance of Organic and Inorganic Aerogels as Patches for Photothermal Therapy
title_sort Biological Thermal Performance of Organic and Inorganic Aerogels as Patches for Photothermal Therapy
author Ferreira-Gonçalves, Tânia
author_facet Ferreira-Gonçalves, Tânia
Iglesias-Mejuto, Ana
Linhares, Teresa
Coelho, João M. P.
Vieira, Pedro
Faísca, Pedro
Catarino, José
Pinto, Pedro
Ferreira, David
Ferreira, Hugo A.
Gaspar, Maria Manuela
Durães, Luísa
García-González, Carlos A.
Reis, Catarina Pinto
author_role author
author2 Iglesias-Mejuto, Ana
Linhares, Teresa
Coelho, João M. P.
Vieira, Pedro
Faísca, Pedro
Catarino, José
Pinto, Pedro
Ferreira, David
Ferreira, Hugo A.
Gaspar, Maria Manuela
Durães, Luísa
García-González, Carlos A.
Reis, Catarina Pinto
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv DF – Departamento de Física
RUN
dc.contributor.author.fl_str_mv Ferreira-Gonçalves, Tânia
Iglesias-Mejuto, Ana
Linhares, Teresa
Coelho, João M. P.
Vieira, Pedro
Faísca, Pedro
Catarino, José
Pinto, Pedro
Ferreira, David
Ferreira, Hugo A.
Gaspar, Maria Manuela
Durães, Luísa
García-González, Carlos A.
Reis, Catarina Pinto
dc.subject.por.fl_str_mv light delimiters
pectin aerogels
silica aerogels
Bioengineering
Biomaterials
Organic Chemistry
Polymers and Plastics
SDG 3 - Good Health and Well-being
topic light delimiters
pectin aerogels
silica aerogels
Bioengineering
Biomaterials
Organic Chemistry
Polymers and Plastics
SDG 3 - Good Health and Well-being
description Funding Information: The authors would like to thank to Fundação para a Ciência e a Tecnologia (FCT) for the essential financial support under project reference UIDB/EQU/00102/2020, and to MICINN [PID2020-120010RB-I00], Agencia Estatal de Investigación [AEI] and FEDER funds. A.I.-M. also acknowledges to Xunta de Galicia for her predoctoral research fellowship [ED481A-2020/104]. Funding Information: This work was performed within the frame of a Short-Term Scientific Mission from COST Action “Advanced Engineering of AeroGels for Environment and Life Sciences” (AERoGELS, ref. CA18125), supported by the COST (European Cooperation in Science and Technology). Moreover, the authors are also grateful to Manuel Fitas from the PhDTrials, Lda for his support. The authors also acknowledge Nuno Costa for its support during DSC analysis and TripleBlue-Pharma Consulting, Lda. ( info@tripleblue.pt ) for revising and editing the manuscript in order to meet English standards. Lastly, the authors are grateful to Carlos Pinheiro, for human skin ex vivo grafts. ® Publisher Copyright: © 2022 by the authors.
publishDate 2022
dc.date.none.fl_str_mv 2022-08-03
2022-08-03T00:00:00Z
2023-03-17T22:30:49Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/150796
url http://hdl.handle.net/10362/150796
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2310-2861
PURE: 56162529
https://doi.org/10.3390/gels8080485
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