Protein microspheres as suitable devices for piroxicam release

Detalhes bibliográficos
Autor(a) principal: Paulo, Artur Cavaco
Data de Publicação: 2012
Outros Autores: Silva, Raquel, Ferreira, Helena, Carvalho, Ana C., Gomes, Andreia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/22595
Resumo: Bovine serum albumin-piroxicam (BSA-piroxicam) and human serum albumin-piroxicam (HSA-piroxicam) microspheres were sonochemically prepared and characterized. The use of polyvinyl alcohol (PVA) lead to an improvement of formulation characteristics, including smaller size, lower polydispersity index (PDl), higher entrapment efficiency and higher stability. The release kinetics of these proteinaceous microspheres was determined in presence of protease, indicating an anomalous drug transport mechanism (diffusion and polymer degradation). In presence of higher protease concentration, BSA microspheres exhibit Case II transport, leading to zero order release (protein degradation). These proteinaceous devices did not show cytotoxicity against human skin fibroblasts in vitro, for range concentrations below to 300 mg L−1, greatly supporting their potential application in the treatment of inflammatory diseases.
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spelling Protein microspheres as suitable devices for piroxicam releaseDrug delivery systemsControlled releasePiroxicamProtein microspheresSonochemistryScience & TechnologyBovine serum albumin-piroxicam (BSA-piroxicam) and human serum albumin-piroxicam (HSA-piroxicam) microspheres were sonochemically prepared and characterized. The use of polyvinyl alcohol (PVA) lead to an improvement of formulation characteristics, including smaller size, lower polydispersity index (PDl), higher entrapment efficiency and higher stability. The release kinetics of these proteinaceous microspheres was determined in presence of protease, indicating an anomalous drug transport mechanism (diffusion and polymer degradation). In presence of higher protease concentration, BSA microspheres exhibit Case II transport, leading to zero order release (protein degradation). These proteinaceous devices did not show cytotoxicity against human skin fibroblasts in vitro, for range concentrations below to 300 mg L−1, greatly supporting their potential application in the treatment of inflammatory diseases.We would like to acknowledge the financial support of European project Lidwine (contract no. NMP2-CT-2006-026741), and to POPH/FSE for co-financing and FCT for fellowship SFRH/BPD/38939/2007.ElsevierUniversidade do MinhoPaulo, Artur CavacoSilva, RaquelFerreira, HelenaCarvalho, Ana C.Gomes, Andreia20122012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/22595eng0927-776510.1016/j.colsurfb.2011.11.05022196462http://dx.doi.org/10.1016/j.colsurfb.2011.11.050info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:32:15Zoai:repositorium.sdum.uminho.pt:1822/22595Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:27:34.270300Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Protein microspheres as suitable devices for piroxicam release
title Protein microspheres as suitable devices for piroxicam release
spellingShingle Protein microspheres as suitable devices for piroxicam release
Paulo, Artur Cavaco
Drug delivery systems
Controlled release
Piroxicam
Protein microspheres
Sonochemistry
Science & Technology
title_short Protein microspheres as suitable devices for piroxicam release
title_full Protein microspheres as suitable devices for piroxicam release
title_fullStr Protein microspheres as suitable devices for piroxicam release
title_full_unstemmed Protein microspheres as suitable devices for piroxicam release
title_sort Protein microspheres as suitable devices for piroxicam release
author Paulo, Artur Cavaco
author_facet Paulo, Artur Cavaco
Silva, Raquel
Ferreira, Helena
Carvalho, Ana C.
Gomes, Andreia
author_role author
author2 Silva, Raquel
Ferreira, Helena
Carvalho, Ana C.
Gomes, Andreia
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Paulo, Artur Cavaco
Silva, Raquel
Ferreira, Helena
Carvalho, Ana C.
Gomes, Andreia
dc.subject.por.fl_str_mv Drug delivery systems
Controlled release
Piroxicam
Protein microspheres
Sonochemistry
Science & Technology
topic Drug delivery systems
Controlled release
Piroxicam
Protein microspheres
Sonochemistry
Science & Technology
description Bovine serum albumin-piroxicam (BSA-piroxicam) and human serum albumin-piroxicam (HSA-piroxicam) microspheres were sonochemically prepared and characterized. The use of polyvinyl alcohol (PVA) lead to an improvement of formulation characteristics, including smaller size, lower polydispersity index (PDl), higher entrapment efficiency and higher stability. The release kinetics of these proteinaceous microspheres was determined in presence of protease, indicating an anomalous drug transport mechanism (diffusion and polymer degradation). In presence of higher protease concentration, BSA microspheres exhibit Case II transport, leading to zero order release (protein degradation). These proteinaceous devices did not show cytotoxicity against human skin fibroblasts in vitro, for range concentrations below to 300 mg L−1, greatly supporting their potential application in the treatment of inflammatory diseases.
publishDate 2012
dc.date.none.fl_str_mv 2012
2012-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/22595
url http://hdl.handle.net/1822/22595
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0927-7765
10.1016/j.colsurfb.2011.11.050
22196462
http://dx.doi.org/10.1016/j.colsurfb.2011.11.050
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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