Bactericidal activity of avian complement: a contribution to understand avian-host tropism of Lyme borreliae
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/49492 |
Resumo: | © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
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Bactericidal activity of avian complement: a contribution to understand avian-host tropism of Lyme borreliaeAvianBirdsBorreliaComplementHost tropismImmune evasionInnate immunityIxodesSpirochetesTick© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.Complement has been considered as an important factor impacting the host-pathogen association of spirochetes belonging to the Borrelia burgdorferi sensu lato complex, and may play a role in the spirochete's ecology. Birds are known to be important hosts for ticks and in the maintenance of borreliae. Recent field surveys and laboratory transmission studies indicated that certain avian species act as reservoir hosts for different Borrelia species. Nevertheless, our current understanding of the molecular mechanisms determining host tropism of Borrelia is still in its fledgling stage. Concerning the role of complement in avian-host tropism, only a few bird species and Borrelia species have been analysed so far. Here, we performed in vitro serum bactericidal assays with serum samples collected from four bird species including the European robin Erithacus rubecula, the great tit Parus major, the Eurasian blackbird Turdus merula, and the racing pigeon Columba livia, as well as four Borrelia species (B. afzelii, B. garinii, B. valaisiana, and B. burgdorferi sensu stricto). From July to September 2019, juvenile wild birds were caught using mist nets in Portugal. Racing pigeons were sampled in a loft in October 2019. Independent of the bird species analysed, all Borrelia species displayed an intermediate serum-resistant or serum-resistant phenotype except for B. afzelii challenged with serum from blackbirds. This genospecies was efficiently killed by avian complement, suggesting that blackbirds served as dead-end hosts for B. afzelii. In summary, these findings suggest that complement contributes in the avian-spirochete-tick infection cycle and in Borrelia-host tropism.Open Access funding enabled and organized by Projekt DEAL. This study received financial support from Fundação para a Ciência e a Tecnologia by the strategic program of MARE (MARE—UID/MAR/04292/2020) and the transitory norm contract DL57/2016/CP1370/CT89 to ACN, and the Portuguese National Institute of Health (INSA).Springer NatureRepositório da Universidade de LisboaSürth, ValerieLopes De Carvalho, IsabelNuncio, Maria SofiaNorte, Ana CláudiaKraiczy, Peter2021-09-09T14:25:26Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/49492engParasit Vectors. 2021 Sep 6;14(1):45110.1186/s13071-021-04959-01756-3305info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:53:17Zoai:repositorio.ul.pt:10451/49492Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:06.906980Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Bactericidal activity of avian complement: a contribution to understand avian-host tropism of Lyme borreliae |
title |
Bactericidal activity of avian complement: a contribution to understand avian-host tropism of Lyme borreliae |
spellingShingle |
Bactericidal activity of avian complement: a contribution to understand avian-host tropism of Lyme borreliae Sürth, Valerie Avian Birds Borrelia Complement Host tropism Immune evasion Innate immunity Ixodes Spirochetes Tick |
title_short |
Bactericidal activity of avian complement: a contribution to understand avian-host tropism of Lyme borreliae |
title_full |
Bactericidal activity of avian complement: a contribution to understand avian-host tropism of Lyme borreliae |
title_fullStr |
Bactericidal activity of avian complement: a contribution to understand avian-host tropism of Lyme borreliae |
title_full_unstemmed |
Bactericidal activity of avian complement: a contribution to understand avian-host tropism of Lyme borreliae |
title_sort |
Bactericidal activity of avian complement: a contribution to understand avian-host tropism of Lyme borreliae |
author |
Sürth, Valerie |
author_facet |
Sürth, Valerie Lopes De Carvalho, Isabel Nuncio, Maria Sofia Norte, Ana Cláudia Kraiczy, Peter |
author_role |
author |
author2 |
Lopes De Carvalho, Isabel Nuncio, Maria Sofia Norte, Ana Cláudia Kraiczy, Peter |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Sürth, Valerie Lopes De Carvalho, Isabel Nuncio, Maria Sofia Norte, Ana Cláudia Kraiczy, Peter |
dc.subject.por.fl_str_mv |
Avian Birds Borrelia Complement Host tropism Immune evasion Innate immunity Ixodes Spirochetes Tick |
topic |
Avian Birds Borrelia Complement Host tropism Immune evasion Innate immunity Ixodes Spirochetes Tick |
description |
© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-09-09T14:25:26Z 2021 2021-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/49492 |
url |
http://hdl.handle.net/10451/49492 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Parasit Vectors. 2021 Sep 6;14(1):451 10.1186/s13071-021-04959-0 1756-3305 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Springer Nature |
publisher.none.fl_str_mv |
Springer Nature |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134558920114176 |