Bactericidal activity of avian complement: a contribution to understand avian-host tropism of Lyme borreliae

Detalhes bibliográficos
Autor(a) principal: Sürth, Valerie
Data de Publicação: 2021
Outros Autores: Lopes De Carvalho, Isabel, Nuncio, Maria Sofia, Norte, Ana Cláudia, Kraiczy, Peter
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/49492
Resumo: © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
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spelling Bactericidal activity of avian complement: a contribution to understand avian-host tropism of Lyme borreliaeAvianBirdsBorreliaComplementHost tropismImmune evasionInnate immunityIxodesSpirochetesTick© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.Complement has been considered as an important factor impacting the host-pathogen association of spirochetes belonging to the Borrelia burgdorferi sensu lato complex, and may play a role in the spirochete's ecology. Birds are known to be important hosts for ticks and in the maintenance of borreliae. Recent field surveys and laboratory transmission studies indicated that certain avian species act as reservoir hosts for different Borrelia species. Nevertheless, our current understanding of the molecular mechanisms determining host tropism of Borrelia is still in its fledgling stage. Concerning the role of complement in avian-host tropism, only a few bird species and Borrelia species have been analysed so far. Here, we performed in vitro serum bactericidal assays with serum samples collected from four bird species including the European robin Erithacus rubecula, the great tit Parus major, the Eurasian blackbird Turdus merula, and the racing pigeon Columba livia, as well as four Borrelia species (B. afzelii, B. garinii, B. valaisiana, and B. burgdorferi sensu stricto). From July to September 2019, juvenile wild birds were caught using mist nets in Portugal. Racing pigeons were sampled in a loft in October 2019. Independent of the bird species analysed, all Borrelia species displayed an intermediate serum-resistant or serum-resistant phenotype except for B. afzelii challenged with serum from blackbirds. This genospecies was efficiently killed by avian complement, suggesting that blackbirds served as dead-end hosts for B. afzelii. In summary, these findings suggest that complement contributes in the avian-spirochete-tick infection cycle and in Borrelia-host tropism.Open Access funding enabled and organized by Projekt DEAL. This study received financial support from Fundação para a Ciência e a Tecnologia by the strategic program of MARE (MARE—UID/MAR/04292/2020) and the transitory norm contract DL57/2016/CP1370/CT89 to ACN, and the Portuguese National Institute of Health (INSA).Springer NatureRepositório da Universidade de LisboaSürth, ValerieLopes De Carvalho, IsabelNuncio, Maria SofiaNorte, Ana CláudiaKraiczy, Peter2021-09-09T14:25:26Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/49492engParasit Vectors. 2021 Sep 6;14(1):45110.1186/s13071-021-04959-01756-3305info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:53:17Zoai:repositorio.ul.pt:10451/49492Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:06.906980Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Bactericidal activity of avian complement: a contribution to understand avian-host tropism of Lyme borreliae
title Bactericidal activity of avian complement: a contribution to understand avian-host tropism of Lyme borreliae
spellingShingle Bactericidal activity of avian complement: a contribution to understand avian-host tropism of Lyme borreliae
Sürth, Valerie
Avian
Birds
Borrelia
Complement
Host tropism
Immune evasion
Innate immunity
Ixodes
Spirochetes
Tick
title_short Bactericidal activity of avian complement: a contribution to understand avian-host tropism of Lyme borreliae
title_full Bactericidal activity of avian complement: a contribution to understand avian-host tropism of Lyme borreliae
title_fullStr Bactericidal activity of avian complement: a contribution to understand avian-host tropism of Lyme borreliae
title_full_unstemmed Bactericidal activity of avian complement: a contribution to understand avian-host tropism of Lyme borreliae
title_sort Bactericidal activity of avian complement: a contribution to understand avian-host tropism of Lyme borreliae
author Sürth, Valerie
author_facet Sürth, Valerie
Lopes De Carvalho, Isabel
Nuncio, Maria Sofia
Norte, Ana Cláudia
Kraiczy, Peter
author_role author
author2 Lopes De Carvalho, Isabel
Nuncio, Maria Sofia
Norte, Ana Cláudia
Kraiczy, Peter
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Sürth, Valerie
Lopes De Carvalho, Isabel
Nuncio, Maria Sofia
Norte, Ana Cláudia
Kraiczy, Peter
dc.subject.por.fl_str_mv Avian
Birds
Borrelia
Complement
Host tropism
Immune evasion
Innate immunity
Ixodes
Spirochetes
Tick
topic Avian
Birds
Borrelia
Complement
Host tropism
Immune evasion
Innate immunity
Ixodes
Spirochetes
Tick
description © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
publishDate 2021
dc.date.none.fl_str_mv 2021-09-09T14:25:26Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/49492
url http://hdl.handle.net/10451/49492
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Parasit Vectors. 2021 Sep 6;14(1):451
10.1186/s13071-021-04959-0
1756-3305
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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