How age, sex and genotype shape the stress response

Detalhes bibliográficos
Autor(a) principal: Novais, Ashley Cruz
Data de Publicação: 2017
Outros Autores: Monteiro, Susana, Roque, Susana, Neves, Margarida Correia, Sousa, Nuno
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/49048
Resumo: Exposure to chronic stress is a leading pre-disposing factor for several neuropsychiatric disorders as it often leads to maladaptive responses. The response to stressful events is heterogeneous, underpinning a wide spectrum of distinct changes amongst stress-exposed individuals'. Several factors can underlie a different perception to stressors and the setting of distinct coping strategies that will lead to individual differences on the susceptibility/resistance to stress. Beyond the factors related to the stressor itself, such as intensity, duration or predictability, there are factors intrinsic to the individuals that are relevant to shape the stress response, such as age, sex and genetics. In this review, we examine the contribution of such intrinsic factors to the modulation of the stress response based on experimental rodent models of response to stress and discuss to what extent that knowledge can be potentially translated to humans.
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spelling How age, sex and genotype shape the stress responseStress modelsAgeSex differencesStressGenotypeCiências Médicas::Medicina BásicaScience & TechnologyExposure to chronic stress is a leading pre-disposing factor for several neuropsychiatric disorders as it often leads to maladaptive responses. The response to stressful events is heterogeneous, underpinning a wide spectrum of distinct changes amongst stress-exposed individuals'. Several factors can underlie a different perception to stressors and the setting of distinct coping strategies that will lead to individual differences on the susceptibility/resistance to stress. Beyond the factors related to the stressor itself, such as intensity, duration or predictability, there are factors intrinsic to the individuals that are relevant to shape the stress response, such as age, sex and genetics. In this review, we examine the contribution of such intrinsic factors to the modulation of the stress response based on experimental rodent models of response to stress and discuss to what extent that knowledge can be potentially translated to humans.FEDER through the Operational Programme Competitiveness Factors - COMPETE and National Funds through FCT - Foundation for Science and Technology under the project POCI-01-0145-FEDER-007038; and by the project NORTE-01-0145-FEDER-000013, supported by Norte Portugal Regional Operational Programme (NORTE, 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). We acknowledge the Portuguese Foundation for Science and Technology (FCT) for providing a post-doctoral fellowship to SR (SFRH/BPD/72710/2010), a doctoral fellowship to SM (SFRH/BD/69311/2010) and a fellowship to AN (ANR/NEU-OSD/0258/2012)info:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoNovais, Ashley CruzMonteiro, SusanaRoque, SusanaNeves, Margarida CorreiaSousa, Nuno2017-02-012017-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/49048engNovais, A., Monteiro, S., Roque, S., Correia-Neves, M., & Sousa, N. (2017). How age, sex and genotype shape the stress response. Neurobiology of Stress, 6, 44-562352-289510.1016/j.ynstr.2016.11.004http://www.sciencedirect.com/science/article/pii/S2352289516300303info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:07:24Zoai:repositorium.sdum.uminho.pt:1822/49048Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:58:22.871234Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv How age, sex and genotype shape the stress response
title How age, sex and genotype shape the stress response
spellingShingle How age, sex and genotype shape the stress response
Novais, Ashley Cruz
Stress models
Age
Sex differences
Stress
Genotype
Ciências Médicas::Medicina Básica
Science & Technology
title_short How age, sex and genotype shape the stress response
title_full How age, sex and genotype shape the stress response
title_fullStr How age, sex and genotype shape the stress response
title_full_unstemmed How age, sex and genotype shape the stress response
title_sort How age, sex and genotype shape the stress response
author Novais, Ashley Cruz
author_facet Novais, Ashley Cruz
Monteiro, Susana
Roque, Susana
Neves, Margarida Correia
Sousa, Nuno
author_role author
author2 Monteiro, Susana
Roque, Susana
Neves, Margarida Correia
Sousa, Nuno
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Novais, Ashley Cruz
Monteiro, Susana
Roque, Susana
Neves, Margarida Correia
Sousa, Nuno
dc.subject.por.fl_str_mv Stress models
Age
Sex differences
Stress
Genotype
Ciências Médicas::Medicina Básica
Science & Technology
topic Stress models
Age
Sex differences
Stress
Genotype
Ciências Médicas::Medicina Básica
Science & Technology
description Exposure to chronic stress is a leading pre-disposing factor for several neuropsychiatric disorders as it often leads to maladaptive responses. The response to stressful events is heterogeneous, underpinning a wide spectrum of distinct changes amongst stress-exposed individuals'. Several factors can underlie a different perception to stressors and the setting of distinct coping strategies that will lead to individual differences on the susceptibility/resistance to stress. Beyond the factors related to the stressor itself, such as intensity, duration or predictability, there are factors intrinsic to the individuals that are relevant to shape the stress response, such as age, sex and genetics. In this review, we examine the contribution of such intrinsic factors to the modulation of the stress response based on experimental rodent models of response to stress and discuss to what extent that knowledge can be potentially translated to humans.
publishDate 2017
dc.date.none.fl_str_mv 2017-02-01
2017-02-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/49048
url http://hdl.handle.net/1822/49048
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Novais, A., Monteiro, S., Roque, S., Correia-Neves, M., & Sousa, N. (2017). How age, sex and genotype shape the stress response. Neurobiology of Stress, 6, 44-56
2352-2895
10.1016/j.ynstr.2016.11.004
http://www.sciencedirect.com/science/article/pii/S2352289516300303
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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