How age, sex and genotype shape the stress response
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/49048 |
Resumo: | Exposure to chronic stress is a leading pre-disposing factor for several neuropsychiatric disorders as it often leads to maladaptive responses. The response to stressful events is heterogeneous, underpinning a wide spectrum of distinct changes amongst stress-exposed individuals'. Several factors can underlie a different perception to stressors and the setting of distinct coping strategies that will lead to individual differences on the susceptibility/resistance to stress. Beyond the factors related to the stressor itself, such as intensity, duration or predictability, there are factors intrinsic to the individuals that are relevant to shape the stress response, such as age, sex and genetics. In this review, we examine the contribution of such intrinsic factors to the modulation of the stress response based on experimental rodent models of response to stress and discuss to what extent that knowledge can be potentially translated to humans. |
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How age, sex and genotype shape the stress responseStress modelsAgeSex differencesStressGenotypeCiências Médicas::Medicina BásicaScience & TechnologyExposure to chronic stress is a leading pre-disposing factor for several neuropsychiatric disorders as it often leads to maladaptive responses. The response to stressful events is heterogeneous, underpinning a wide spectrum of distinct changes amongst stress-exposed individuals'. Several factors can underlie a different perception to stressors and the setting of distinct coping strategies that will lead to individual differences on the susceptibility/resistance to stress. Beyond the factors related to the stressor itself, such as intensity, duration or predictability, there are factors intrinsic to the individuals that are relevant to shape the stress response, such as age, sex and genetics. In this review, we examine the contribution of such intrinsic factors to the modulation of the stress response based on experimental rodent models of response to stress and discuss to what extent that knowledge can be potentially translated to humans.FEDER through the Operational Programme Competitiveness Factors - COMPETE and National Funds through FCT - Foundation for Science and Technology under the project POCI-01-0145-FEDER-007038; and by the project NORTE-01-0145-FEDER-000013, supported by Norte Portugal Regional Operational Programme (NORTE, 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). We acknowledge the Portuguese Foundation for Science and Technology (FCT) for providing a post-doctoral fellowship to SR (SFRH/BPD/72710/2010), a doctoral fellowship to SM (SFRH/BD/69311/2010) and a fellowship to AN (ANR/NEU-OSD/0258/2012)info:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoNovais, Ashley CruzMonteiro, SusanaRoque, SusanaNeves, Margarida CorreiaSousa, Nuno2017-02-012017-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/49048engNovais, A., Monteiro, S., Roque, S., Correia-Neves, M., & Sousa, N. (2017). How age, sex and genotype shape the stress response. Neurobiology of Stress, 6, 44-562352-289510.1016/j.ynstr.2016.11.004http://www.sciencedirect.com/science/article/pii/S2352289516300303info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:07:24Zoai:repositorium.sdum.uminho.pt:1822/49048Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:58:22.871234Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
How age, sex and genotype shape the stress response |
title |
How age, sex and genotype shape the stress response |
spellingShingle |
How age, sex and genotype shape the stress response Novais, Ashley Cruz Stress models Age Sex differences Stress Genotype Ciências Médicas::Medicina Básica Science & Technology |
title_short |
How age, sex and genotype shape the stress response |
title_full |
How age, sex and genotype shape the stress response |
title_fullStr |
How age, sex and genotype shape the stress response |
title_full_unstemmed |
How age, sex and genotype shape the stress response |
title_sort |
How age, sex and genotype shape the stress response |
author |
Novais, Ashley Cruz |
author_facet |
Novais, Ashley Cruz Monteiro, Susana Roque, Susana Neves, Margarida Correia Sousa, Nuno |
author_role |
author |
author2 |
Monteiro, Susana Roque, Susana Neves, Margarida Correia Sousa, Nuno |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Novais, Ashley Cruz Monteiro, Susana Roque, Susana Neves, Margarida Correia Sousa, Nuno |
dc.subject.por.fl_str_mv |
Stress models Age Sex differences Stress Genotype Ciências Médicas::Medicina Básica Science & Technology |
topic |
Stress models Age Sex differences Stress Genotype Ciências Médicas::Medicina Básica Science & Technology |
description |
Exposure to chronic stress is a leading pre-disposing factor for several neuropsychiatric disorders as it often leads to maladaptive responses. The response to stressful events is heterogeneous, underpinning a wide spectrum of distinct changes amongst stress-exposed individuals'. Several factors can underlie a different perception to stressors and the setting of distinct coping strategies that will lead to individual differences on the susceptibility/resistance to stress. Beyond the factors related to the stressor itself, such as intensity, duration or predictability, there are factors intrinsic to the individuals that are relevant to shape the stress response, such as age, sex and genetics. In this review, we examine the contribution of such intrinsic factors to the modulation of the stress response based on experimental rodent models of response to stress and discuss to what extent that knowledge can be potentially translated to humans. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-02-01 2017-02-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/49048 |
url |
http://hdl.handle.net/1822/49048 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Novais, A., Monteiro, S., Roque, S., Correia-Neves, M., & Sousa, N. (2017). How age, sex and genotype shape the stress response. Neurobiology of Stress, 6, 44-56 2352-2895 10.1016/j.ynstr.2016.11.004 http://www.sciencedirect.com/science/article/pii/S2352289516300303 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132373552463872 |