Inflammatory Myofibroblastic Tumour of the Common Bile Duct

Detalhes bibliográficos
Autor(a) principal: Almeida E Sousa, Matilde
Data de Publicação: 2022
Outros Autores: Carvalho, Ana, Mega, Raquel, Bilhim, Tiago
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/147353
Resumo: Inflammatory myofibroblastic tumour is a rare entity of indeterminate biological potential with a reduced tendency for recurrence and metastasis. Although it can arise from multiple organs, the bile duct is a very rare site of origin. We report the case of a 75-year-old asymptomatic male with elevated gamma-glutamyl transferase [1575 U/L (12 - 64 U/L)] and alkaline phosphatase [271 U/L (40 - 150 U/L)]. Computed tomography showed a 17 mm hypervascular lesion in the confluence of the right and left hepatic ducts, with bile duct ectasia and right liver lobe atrophy. The patient was initially managed as having a Klatskin tumour and underwent right hepatectomy. Histology showed a spindle cell proliferation with an inflammatory infiltrate of lymphocytes, plasma cells and collagen-rich stroma, consistent with an inflammatory myofibroblastic tumour. He was discharged 30 days after admission, and nine months later remains asymptomatic. His liver function tests have normalized and follow-up tests are unremarkable.
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spelling Inflammatory Myofibroblastic Tumour of the Common Bile DuctBile Duct NeoplasmsHepatectomyHepatic DuctCommonKlatskin TumourLiver Function TestsInflammatory myofibroblastic tumour is a rare entity of indeterminate biological potential with a reduced tendency for recurrence and metastasis. Although it can arise from multiple organs, the bile duct is a very rare site of origin. We report the case of a 75-year-old asymptomatic male with elevated gamma-glutamyl transferase [1575 U/L (12 - 64 U/L)] and alkaline phosphatase [271 U/L (40 - 150 U/L)]. Computed tomography showed a 17 mm hypervascular lesion in the confluence of the right and left hepatic ducts, with bile duct ectasia and right liver lobe atrophy. The patient was initially managed as having a Klatskin tumour and underwent right hepatectomy. Histology showed a spindle cell proliferation with an inflammatory infiltrate of lymphocytes, plasma cells and collagen-rich stroma, consistent with an inflammatory myofibroblastic tumour. He was discharged 30 days after admission, and nine months later remains asymptomatic. His liver function tests have normalized and follow-up tests are unremarkable.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNAlmeida E Sousa, MatildeCarvalho, AnaMega, RaquelBilhim, Tiago2023-01-11T22:15:52Z2022-102022-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/147353eng1646-0758PURE: 41768595https://doi.org/10.20344/amp.11641info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:28:25Zoai:run.unl.pt:10362/147353Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:52:52.856247Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Inflammatory Myofibroblastic Tumour of the Common Bile Duct
title Inflammatory Myofibroblastic Tumour of the Common Bile Duct
spellingShingle Inflammatory Myofibroblastic Tumour of the Common Bile Duct
Almeida E Sousa, Matilde
Bile Duct Neoplasms
Hepatectomy
Hepatic Duct
Common
Klatskin Tumour
Liver Function Tests
title_short Inflammatory Myofibroblastic Tumour of the Common Bile Duct
title_full Inflammatory Myofibroblastic Tumour of the Common Bile Duct
title_fullStr Inflammatory Myofibroblastic Tumour of the Common Bile Duct
title_full_unstemmed Inflammatory Myofibroblastic Tumour of the Common Bile Duct
title_sort Inflammatory Myofibroblastic Tumour of the Common Bile Duct
author Almeida E Sousa, Matilde
author_facet Almeida E Sousa, Matilde
Carvalho, Ana
Mega, Raquel
Bilhim, Tiago
author_role author
author2 Carvalho, Ana
Mega, Raquel
Bilhim, Tiago
author2_role author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Almeida E Sousa, Matilde
Carvalho, Ana
Mega, Raquel
Bilhim, Tiago
dc.subject.por.fl_str_mv Bile Duct Neoplasms
Hepatectomy
Hepatic Duct
Common
Klatskin Tumour
Liver Function Tests
topic Bile Duct Neoplasms
Hepatectomy
Hepatic Duct
Common
Klatskin Tumour
Liver Function Tests
description Inflammatory myofibroblastic tumour is a rare entity of indeterminate biological potential with a reduced tendency for recurrence and metastasis. Although it can arise from multiple organs, the bile duct is a very rare site of origin. We report the case of a 75-year-old asymptomatic male with elevated gamma-glutamyl transferase [1575 U/L (12 - 64 U/L)] and alkaline phosphatase [271 U/L (40 - 150 U/L)]. Computed tomography showed a 17 mm hypervascular lesion in the confluence of the right and left hepatic ducts, with bile duct ectasia and right liver lobe atrophy. The patient was initially managed as having a Klatskin tumour and underwent right hepatectomy. Histology showed a spindle cell proliferation with an inflammatory infiltrate of lymphocytes, plasma cells and collagen-rich stroma, consistent with an inflammatory myofibroblastic tumour. He was discharged 30 days after admission, and nine months later remains asymptomatic. His liver function tests have normalized and follow-up tests are unremarkable.
publishDate 2022
dc.date.none.fl_str_mv 2022-10
2022-10-01T00:00:00Z
2023-01-11T22:15:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/147353
url http://hdl.handle.net/10362/147353
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1646-0758
PURE: 41768595
https://doi.org/10.20344/amp.11641
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