Minimally invasive surfactant therapy in preterm infants: towards less invasive management
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.16/2499 |
Resumo: | Introduction: Minimally invasive surfactant therapy (MIST) is a surfactant administration procedure that intends to reduce intubations and associated risks. The aim of this study was to compare MIST with INtubation-SURfactant-Extubation (INSURE) technique. Material and methods: Retrospective analysis (from January 2015 to June 2019) of preterm infants on nasal continuous positive airway pressure (nCPAP) treated with surfactant. Results: Fifty-four preterm infants were included and divided in two groups: MIST (n=34) and INSURE (n=20). No significant differences were found between groups regarding gestational age (p=0.480), birth weight (p=0.299), fraction of inspired oxygen (FiO2) prior to surfactant (p=0.220), oxygen therapy duration (p=0.306), progression to intubation (p=0.712), or length of Neonatal Intensive Care Unit stay (p=0.778). FiO2 variation before and after surfactant administration was higher in MIST group (14% vs 9%, p=0.078). No significant complications were reported with either technique. Conclusions: MIST is a safe technique in preterm infants on nCPAP. This study shows similar outcomes with MIST and INSURE procedures, with a greater reduction in FiO2 requirements with MIST. Overall, MIST is less invasive and as effective as INSURE in preterm infants. |
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Minimally invasive surfactant therapy in preterm infants: towards less invasive managementTerapêutica com surfactante em recém-nascidos pré-termo: tendência para uma abordagem menos invasivaINSUREMISTpretermsurfactantventilationIntroduction: Minimally invasive surfactant therapy (MIST) is a surfactant administration procedure that intends to reduce intubations and associated risks. The aim of this study was to compare MIST with INtubation-SURfactant-Extubation (INSURE) technique. Material and methods: Retrospective analysis (from January 2015 to June 2019) of preterm infants on nasal continuous positive airway pressure (nCPAP) treated with surfactant. Results: Fifty-four preterm infants were included and divided in two groups: MIST (n=34) and INSURE (n=20). No significant differences were found between groups regarding gestational age (p=0.480), birth weight (p=0.299), fraction of inspired oxygen (FiO2) prior to surfactant (p=0.220), oxygen therapy duration (p=0.306), progression to intubation (p=0.712), or length of Neonatal Intensive Care Unit stay (p=0.778). FiO2 variation before and after surfactant administration was higher in MIST group (14% vs 9%, p=0.078). No significant complications were reported with either technique. Conclusions: MIST is a safe technique in preterm infants on nCPAP. This study shows similar outcomes with MIST and INSURE procedures, with a greater reduction in FiO2 requirements with MIST. Overall, MIST is less invasive and as effective as INSURE in preterm infants.Centro Hospitalar Universitário do PortoRepositório Científico do Centro Hospitalar Universitário de Santo AntónioMeireles, DanielNeiva-Araújo, LuísaNascimento, MartaPinho, LilianaFreitas, Ana CristinaAlmeida, AlexandraCarvalho, CarmenProença, Elisa2021-09-30T10:28:34Z2021-032021-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.16/2499engMeireles D, Neiva-Araújo L, Nascimento M, Pinho L, Freitas AC, Almeida A, Carvalho C, Proença E, Nascer e Crescer - Birth and Growth Medical Journal 2021;30(1): 18-25. doi:10.25753/BirthGrowthMJ.v30.i1.191822183-941710.25753/BirthGrowthMJ.v30.i1.19182info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-20T11:00:55Zoai:repositorio.chporto.pt:10400.16/2499Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:38:42.753022Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Minimally invasive surfactant therapy in preterm infants: towards less invasive management Terapêutica com surfactante em recém-nascidos pré-termo: tendência para uma abordagem menos invasiva |
title |
Minimally invasive surfactant therapy in preterm infants: towards less invasive management |
spellingShingle |
Minimally invasive surfactant therapy in preterm infants: towards less invasive management Meireles, Daniel INSURE MIST preterm surfactant ventilation |
title_short |
Minimally invasive surfactant therapy in preterm infants: towards less invasive management |
title_full |
Minimally invasive surfactant therapy in preterm infants: towards less invasive management |
title_fullStr |
Minimally invasive surfactant therapy in preterm infants: towards less invasive management |
title_full_unstemmed |
Minimally invasive surfactant therapy in preterm infants: towards less invasive management |
title_sort |
Minimally invasive surfactant therapy in preterm infants: towards less invasive management |
author |
Meireles, Daniel |
author_facet |
Meireles, Daniel Neiva-Araújo, Luísa Nascimento, Marta Pinho, Liliana Freitas, Ana Cristina Almeida, Alexandra Carvalho, Carmen Proença, Elisa |
author_role |
author |
author2 |
Neiva-Araújo, Luísa Nascimento, Marta Pinho, Liliana Freitas, Ana Cristina Almeida, Alexandra Carvalho, Carmen Proença, Elisa |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Centro Hospitalar Universitário de Santo António |
dc.contributor.author.fl_str_mv |
Meireles, Daniel Neiva-Araújo, Luísa Nascimento, Marta Pinho, Liliana Freitas, Ana Cristina Almeida, Alexandra Carvalho, Carmen Proença, Elisa |
dc.subject.por.fl_str_mv |
INSURE MIST preterm surfactant ventilation |
topic |
INSURE MIST preterm surfactant ventilation |
description |
Introduction: Minimally invasive surfactant therapy (MIST) is a surfactant administration procedure that intends to reduce intubations and associated risks. The aim of this study was to compare MIST with INtubation-SURfactant-Extubation (INSURE) technique. Material and methods: Retrospective analysis (from January 2015 to June 2019) of preterm infants on nasal continuous positive airway pressure (nCPAP) treated with surfactant. Results: Fifty-four preterm infants were included and divided in two groups: MIST (n=34) and INSURE (n=20). No significant differences were found between groups regarding gestational age (p=0.480), birth weight (p=0.299), fraction of inspired oxygen (FiO2) prior to surfactant (p=0.220), oxygen therapy duration (p=0.306), progression to intubation (p=0.712), or length of Neonatal Intensive Care Unit stay (p=0.778). FiO2 variation before and after surfactant administration was higher in MIST group (14% vs 9%, p=0.078). No significant complications were reported with either technique. Conclusions: MIST is a safe technique in preterm infants on nCPAP. This study shows similar outcomes with MIST and INSURE procedures, with a greater reduction in FiO2 requirements with MIST. Overall, MIST is less invasive and as effective as INSURE in preterm infants. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-09-30T10:28:34Z 2021-03 2021-03-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.16/2499 |
url |
http://hdl.handle.net/10400.16/2499 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Meireles D, Neiva-Araújo L, Nascimento M, Pinho L, Freitas AC, Almeida A, Carvalho C, Proença E, Nascer e Crescer - Birth and Growth Medical Journal 2021;30(1): 18-25. doi:10.25753/BirthGrowthMJ.v30.i1.19182 2183-9417 10.25753/BirthGrowthMJ.v30.i1.19182 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Centro Hospitalar Universitário do Porto |
publisher.none.fl_str_mv |
Centro Hospitalar Universitário do Porto |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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