Cell secretome based approaches in Parkinson's disease regenerative medicine
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/57891 |
Resumo: | The available therapeutic strategies for Parkinson's disease (PD) rely only on the amelioration of the symptomatology of the disease, lacking neuroprotection or neuroregeneration capacities. Therefore, the development of disease modifying strategies is extremely important for the management of PD in the long term. Areas covered: In this review, the authors provide an overview of the current therapeutic approaches for PD and the emerging use of stem cell transplantation as an alternative. Particularly, the use of the secretome from mesenchymal stem cells (MSCs), as well as some methodologies used for the modulation of their paracrine signaling, will be discussed. Indeed, there is a growing body of literature highlighting the use of paracrine factors and vesicles secreted from different cell populations, for this purpose. Expert opinion: Secretome from MSCs has shown its potential as a therapy for PD. Nevertheless, in the coming years, research should focus in several key aspects to enable the translation of this strategy from the bench to the bedside. |
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Cell secretome based approaches in Parkinson's disease regenerative medicineBiomaterialsBioreactorsDopamineDopaminergic neuronsHypoxiaMesenchymal stem cellsNeural derived cellsParkinson’s diseaseSecretomeCiências Médicas::Medicina BásicaScience & TechnologyThe available therapeutic strategies for Parkinson's disease (PD) rely only on the amelioration of the symptomatology of the disease, lacking neuroprotection or neuroregeneration capacities. Therefore, the development of disease modifying strategies is extremely important for the management of PD in the long term. Areas covered: In this review, the authors provide an overview of the current therapeutic approaches for PD and the emerging use of stem cell transplantation as an alternative. Particularly, the use of the secretome from mesenchymal stem cells (MSCs), as well as some methodologies used for the modulation of their paracrine signaling, will be discussed. Indeed, there is a growing body of literature highlighting the use of paracrine factors and vesicles secreted from different cell populations, for this purpose. Expert opinion: Secretome from MSCs has shown its potential as a therapy for PD. Nevertheless, in the coming years, research should focus in several key aspects to enable the translation of this strategy from the bench to the bedside.Portuguese Foundation for Science and Technology (FCT): Ciência 2007 Program and IF Development Grant [IF/00111/2013] to AJ Salgado, PhD scholarships attributed to C.R. Marques [PD/BDE/127833/2016], A. Marote [PDE/BDE/113598/2015] and B. Mendes-Pinheiro [SFRH/BD/120124/2016] and Post-Doctoral Fellowship to F.G. Teixeira [SFRH/BPD/118408/2016]. This article has been developed under the scope of the project NORTE-01-0145-FEDER-000023, supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER). This work has been funded by FEDER funds, through the Competitiveness Factors Operational Programme (COMPETE), and by National funds, through FCT, under the scope of the project [POCI-01-0145-FEDER-007038]info:eu-repo/semantics/publishedVersionTaylor & FrancisUniversidade do MinhoMarques, Cláudia R.Marote, Ana Maria Franco AveiroPinheiro, Bárbara Filipa MendesTeixeira, Fábio Gabriel RodriguesSalgado, A. J.2018-122018-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/57891engMarques, C. R., Marote, A., Mendes-Pinheiro, B., Teixeira, F. G., & Salgado, A. J. (2018). Cell secretome based approaches in Parkinson’s disease regenerative medicine. Expert opinion on biological therapy, 18(12), 1235-12451471-25981744-768210.1080/14712598.2018.154684030422014https://www.tandfonline.com/doi/abs/10.1080/14712598.2018.1546840info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:48:05Zoai:repositorium.sdum.uminho.pt:1822/57891Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:46:15.645344Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Cell secretome based approaches in Parkinson's disease regenerative medicine |
title |
Cell secretome based approaches in Parkinson's disease regenerative medicine |
spellingShingle |
Cell secretome based approaches in Parkinson's disease regenerative medicine Marques, Cláudia R. Biomaterials Bioreactors Dopamine Dopaminergic neurons Hypoxia Mesenchymal stem cells Neural derived cells Parkinson’s disease Secretome Ciências Médicas::Medicina Básica Science & Technology |
title_short |
Cell secretome based approaches in Parkinson's disease regenerative medicine |
title_full |
Cell secretome based approaches in Parkinson's disease regenerative medicine |
title_fullStr |
Cell secretome based approaches in Parkinson's disease regenerative medicine |
title_full_unstemmed |
Cell secretome based approaches in Parkinson's disease regenerative medicine |
title_sort |
Cell secretome based approaches in Parkinson's disease regenerative medicine |
author |
Marques, Cláudia R. |
author_facet |
Marques, Cláudia R. Marote, Ana Maria Franco Aveiro Pinheiro, Bárbara Filipa Mendes Teixeira, Fábio Gabriel Rodrigues Salgado, A. J. |
author_role |
author |
author2 |
Marote, Ana Maria Franco Aveiro Pinheiro, Bárbara Filipa Mendes Teixeira, Fábio Gabriel Rodrigues Salgado, A. J. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Marques, Cláudia R. Marote, Ana Maria Franco Aveiro Pinheiro, Bárbara Filipa Mendes Teixeira, Fábio Gabriel Rodrigues Salgado, A. J. |
dc.subject.por.fl_str_mv |
Biomaterials Bioreactors Dopamine Dopaminergic neurons Hypoxia Mesenchymal stem cells Neural derived cells Parkinson’s disease Secretome Ciências Médicas::Medicina Básica Science & Technology |
topic |
Biomaterials Bioreactors Dopamine Dopaminergic neurons Hypoxia Mesenchymal stem cells Neural derived cells Parkinson’s disease Secretome Ciências Médicas::Medicina Básica Science & Technology |
description |
The available therapeutic strategies for Parkinson's disease (PD) rely only on the amelioration of the symptomatology of the disease, lacking neuroprotection or neuroregeneration capacities. Therefore, the development of disease modifying strategies is extremely important for the management of PD in the long term. Areas covered: In this review, the authors provide an overview of the current therapeutic approaches for PD and the emerging use of stem cell transplantation as an alternative. Particularly, the use of the secretome from mesenchymal stem cells (MSCs), as well as some methodologies used for the modulation of their paracrine signaling, will be discussed. Indeed, there is a growing body of literature highlighting the use of paracrine factors and vesicles secreted from different cell populations, for this purpose. Expert opinion: Secretome from MSCs has shown its potential as a therapy for PD. Nevertheless, in the coming years, research should focus in several key aspects to enable the translation of this strategy from the bench to the bedside. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12 2018-12-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/57891 |
url |
http://hdl.handle.net/1822/57891 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Marques, C. R., Marote, A., Mendes-Pinheiro, B., Teixeira, F. G., & Salgado, A. J. (2018). Cell secretome based approaches in Parkinson’s disease regenerative medicine. Expert opinion on biological therapy, 18(12), 1235-1245 1471-2598 1744-7682 10.1080/14712598.2018.1546840 30422014 https://www.tandfonline.com/doi/abs/10.1080/14712598.2018.1546840 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Taylor & Francis |
publisher.none.fl_str_mv |
Taylor & Francis |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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