Glycosylation in cancer: Mechanisms and clinical implications
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://repositorio-aberto.up.pt/handle/10216/118208 |
Resumo: | Despite recent progress in understanding the cancer genome, there is still a relative delay in understanding the full aspects of the glycome and glycoproteome of cancer. Glycobiology has been instrumental in relevant discoveries in various biological and medical fields, and has contributed to the deciphering of several human diseases. Glycans are involved in fundamental molecular and cell biology processes occurring in cancer, such as cell signalling and communication, tumour cell dissociation and invasion, cell-matrix interactions, tumour angiogenesis, immune modulation and metastasis formation. The roles of glycans in cancer have been highlighted by the fact that alterations in glycosylation regulate the development and progression of cancer, serving as important biomarkers and providing a set of specific targets for therapeutic intervention. This Review discusses the role of glycans in fundamental mechanisms controlling cancer development and progression, and their applications in oncology. |
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Glycosylation in cancer: Mechanisms and clinical implicationsGlycoconjugates/metabolismGlycosylationHumansNeoplasms/diagnosisNeoplasms/immunologyNeoplasms/metabolismNeoplasms/pathologyNeoplasms/therapyPolysaccharides/immunologyPolysaccharides/metabolismDespite recent progress in understanding the cancer genome, there is still a relative delay in understanding the full aspects of the glycome and glycoproteome of cancer. Glycobiology has been instrumental in relevant discoveries in various biological and medical fields, and has contributed to the deciphering of several human diseases. Glycans are involved in fundamental molecular and cell biology processes occurring in cancer, such as cell signalling and communication, tumour cell dissociation and invasion, cell-matrix interactions, tumour angiogenesis, immune modulation and metastasis formation. The roles of glycans in cancer have been highlighted by the fact that alterations in glycosylation regulate the development and progression of cancer, serving as important biomarkers and providing a set of specific targets for therapeutic intervention. This Review discusses the role of glycans in fundamental mechanisms controlling cancer development and progression, and their applications in oncology.Nature Publishing Group20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://repositorio-aberto.up.pt/handle/10216/118208eng1474-175X10.1038/nrc3982Pinho, SSReis, CAinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T14:19:25Zoai:repositorio-aberto.up.pt:10216/118208Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:58:53.095430Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Glycosylation in cancer: Mechanisms and clinical implications |
title |
Glycosylation in cancer: Mechanisms and clinical implications |
spellingShingle |
Glycosylation in cancer: Mechanisms and clinical implications Pinho, SS Glycoconjugates/metabolism Glycosylation Humans Neoplasms/diagnosis Neoplasms/immunology Neoplasms/metabolism Neoplasms/pathology Neoplasms/therapy Polysaccharides/immunology Polysaccharides/metabolism |
title_short |
Glycosylation in cancer: Mechanisms and clinical implications |
title_full |
Glycosylation in cancer: Mechanisms and clinical implications |
title_fullStr |
Glycosylation in cancer: Mechanisms and clinical implications |
title_full_unstemmed |
Glycosylation in cancer: Mechanisms and clinical implications |
title_sort |
Glycosylation in cancer: Mechanisms and clinical implications |
author |
Pinho, SS |
author_facet |
Pinho, SS Reis, CA |
author_role |
author |
author2 |
Reis, CA |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Pinho, SS Reis, CA |
dc.subject.por.fl_str_mv |
Glycoconjugates/metabolism Glycosylation Humans Neoplasms/diagnosis Neoplasms/immunology Neoplasms/metabolism Neoplasms/pathology Neoplasms/therapy Polysaccharides/immunology Polysaccharides/metabolism |
topic |
Glycoconjugates/metabolism Glycosylation Humans Neoplasms/diagnosis Neoplasms/immunology Neoplasms/metabolism Neoplasms/pathology Neoplasms/therapy Polysaccharides/immunology Polysaccharides/metabolism |
description |
Despite recent progress in understanding the cancer genome, there is still a relative delay in understanding the full aspects of the glycome and glycoproteome of cancer. Glycobiology has been instrumental in relevant discoveries in various biological and medical fields, and has contributed to the deciphering of several human diseases. Glycans are involved in fundamental molecular and cell biology processes occurring in cancer, such as cell signalling and communication, tumour cell dissociation and invasion, cell-matrix interactions, tumour angiogenesis, immune modulation and metastasis formation. The roles of glycans in cancer have been highlighted by the fact that alterations in glycosylation regulate the development and progression of cancer, serving as important biomarkers and providing a set of specific targets for therapeutic intervention. This Review discusses the role of glycans in fundamental mechanisms controlling cancer development and progression, and their applications in oncology. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015 2015-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://repositorio-aberto.up.pt/handle/10216/118208 |
url |
https://repositorio-aberto.up.pt/handle/10216/118208 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1474-175X 10.1038/nrc3982 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799135911985807360 |