Bioactivity of ionic liquids based on valproate in SH-SY5Y human neuroblastoma cell line
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.22/23770 |
Resumo: | The search for alternative and effective therapies to fight cancer is one of the main goals of the pharmaceutical industry. Recently, ionic liquids (ILs) have emerged as potential therapeutic agents with antitumor properties. The goal of this study was to synthesize and evaluate the bioactivity of different ILs coupled with the active pharmaceutical ingredient (API) valproate (VPA) as an antitumor agent. The toxicity of the prepared ionic liquids was evaluated by the MTT cell metabolic assay in human neuroblastoma SH-SY5Y and human primary Gingival Fibroblast (GF) cell lines, in which they showed inhibitory effects during the study period. In addition, low cytotoxicity against GF cell lines was observed, suggesting that these compounds are not toxic to human cell lines. [C2OHDMiM][VPA] demonstrated an outstanding antitumor activity against SH-SY5Y and lower activity against the non-neoplastic GF line. The herein assessed compounds played an important role in the modulation of the signaling pathways involved in the cellular behavior. This work also highlights the potential of these ILs-API as possible antitumor agents. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Bioactivity of ionic liquids based on valproate in SH-SY5Y human neuroblastoma cell lineIonic liquidsValproic acidActive pharmaceutical ingredientsAntitumor agentsNeuroblastomaSignaling pathwaysThe search for alternative and effective therapies to fight cancer is one of the main goals of the pharmaceutical industry. Recently, ionic liquids (ILs) have emerged as potential therapeutic agents with antitumor properties. The goal of this study was to synthesize and evaluate the bioactivity of different ILs coupled with the active pharmaceutical ingredient (API) valproate (VPA) as an antitumor agent. The toxicity of the prepared ionic liquids was evaluated by the MTT cell metabolic assay in human neuroblastoma SH-SY5Y and human primary Gingival Fibroblast (GF) cell lines, in which they showed inhibitory effects during the study period. In addition, low cytotoxicity against GF cell lines was observed, suggesting that these compounds are not toxic to human cell lines. [C2OHDMiM][VPA] demonstrated an outstanding antitumor activity against SH-SY5Y and lower activity against the non-neoplastic GF line. The herein assessed compounds played an important role in the modulation of the signaling pathways involved in the cellular behavior. This work also highlights the potential of these ILs-API as possible antitumor agents.MDPIRepositório Científico do Instituto Politécnico do PortoDias, Ana RitaFerraz, RicardoCosta-Rodrigues, JoãoSantos, Andreia F. M.Jacinto, Manuel L.Prudêncio, CristinaNoronha, João PauloBranco, Luís C.Petrovsk, Željko2023-10-25T13:13:45Z2022-08-312022-08-31T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/23770engDias, A. R., Ferraz, R., Costa-Rodrigues, J., Santos, A. F. M., Jacinto, M. L., Prudêncio, C., Noronha, J. P., Branco, L. C., & Petrovski, Ž. (2022). Bioactivity of Ionic Liquids Based on Valproate in SH-SY5Y Human Neuroblastoma Cell Line. Future Pharmacology, 2(3), 320–329. https://doi.org/10.3390/futurepharmacol20300222673-9879doi.org/10.3390/futurepharmacol2030022info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-24T01:49:21Zoai:recipp.ipp.pt:10400.22/23770Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:26:12.478061Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Bioactivity of ionic liquids based on valproate in SH-SY5Y human neuroblastoma cell line |
title |
Bioactivity of ionic liquids based on valproate in SH-SY5Y human neuroblastoma cell line |
spellingShingle |
Bioactivity of ionic liquids based on valproate in SH-SY5Y human neuroblastoma cell line Dias, Ana Rita Ionic liquids Valproic acid Active pharmaceutical ingredients Antitumor agents Neuroblastoma Signaling pathways |
title_short |
Bioactivity of ionic liquids based on valproate in SH-SY5Y human neuroblastoma cell line |
title_full |
Bioactivity of ionic liquids based on valproate in SH-SY5Y human neuroblastoma cell line |
title_fullStr |
Bioactivity of ionic liquids based on valproate in SH-SY5Y human neuroblastoma cell line |
title_full_unstemmed |
Bioactivity of ionic liquids based on valproate in SH-SY5Y human neuroblastoma cell line |
title_sort |
Bioactivity of ionic liquids based on valproate in SH-SY5Y human neuroblastoma cell line |
author |
Dias, Ana Rita |
author_facet |
Dias, Ana Rita Ferraz, Ricardo Costa-Rodrigues, João Santos, Andreia F. M. Jacinto, Manuel L. Prudêncio, Cristina Noronha, João Paulo Branco, Luís C. Petrovsk, Željko |
author_role |
author |
author2 |
Ferraz, Ricardo Costa-Rodrigues, João Santos, Andreia F. M. Jacinto, Manuel L. Prudêncio, Cristina Noronha, João Paulo Branco, Luís C. Petrovsk, Željko |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Politécnico do Porto |
dc.contributor.author.fl_str_mv |
Dias, Ana Rita Ferraz, Ricardo Costa-Rodrigues, João Santos, Andreia F. M. Jacinto, Manuel L. Prudêncio, Cristina Noronha, João Paulo Branco, Luís C. Petrovsk, Željko |
dc.subject.por.fl_str_mv |
Ionic liquids Valproic acid Active pharmaceutical ingredients Antitumor agents Neuroblastoma Signaling pathways |
topic |
Ionic liquids Valproic acid Active pharmaceutical ingredients Antitumor agents Neuroblastoma Signaling pathways |
description |
The search for alternative and effective therapies to fight cancer is one of the main goals of the pharmaceutical industry. Recently, ionic liquids (ILs) have emerged as potential therapeutic agents with antitumor properties. The goal of this study was to synthesize and evaluate the bioactivity of different ILs coupled with the active pharmaceutical ingredient (API) valproate (VPA) as an antitumor agent. The toxicity of the prepared ionic liquids was evaluated by the MTT cell metabolic assay in human neuroblastoma SH-SY5Y and human primary Gingival Fibroblast (GF) cell lines, in which they showed inhibitory effects during the study period. In addition, low cytotoxicity against GF cell lines was observed, suggesting that these compounds are not toxic to human cell lines. [C2OHDMiM][VPA] demonstrated an outstanding antitumor activity against SH-SY5Y and lower activity against the non-neoplastic GF line. The herein assessed compounds played an important role in the modulation of the signaling pathways involved in the cellular behavior. This work also highlights the potential of these ILs-API as possible antitumor agents. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-08-31 2022-08-31T00:00:00Z 2023-10-25T13:13:45Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.22/23770 |
url |
http://hdl.handle.net/10400.22/23770 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Dias, A. R., Ferraz, R., Costa-Rodrigues, J., Santos, A. F. M., Jacinto, M. L., Prudêncio, C., Noronha, J. P., Branco, L. C., & Petrovski, Ž. (2022). Bioactivity of Ionic Liquids Based on Valproate in SH-SY5Y Human Neuroblastoma Cell Line. Future Pharmacology, 2(3), 320–329. https://doi.org/10.3390/futurepharmacol2030022 2673-9879 doi.org/10.3390/futurepharmacol2030022 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134143740641280 |