Peptidoglycan synthesis and penicillin resistance in Streptococcus pneumoniae

Detalhes bibliográficos
Autor(a) principal: Narciso, Ana Rita da Cruz
Data de Publicação: 2018
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/94060
Resumo: "Resistance to penicillin in Streptococcus pneumoniae involves remodelling of penicillin-binding proteins (PBPs), enzymes involved in the last stages of peptidoglycan (PGN) synthesis, which reduce the affinity of these targets to the antibiotic. However, the peptidoglycan composition has an important role in the expression of resistance to this antibiotic. The murMN operon in particular seems to play a critical role, since deletion lead to the complete abolishment of penicillin resistance, even in the presence of the remodelled PBPs. (...)"
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spelling Peptidoglycan synthesis and penicillin resistance in Streptococcus pneumoniaepenicillin resistanceStreptococcus pneumoniaeBiology"Resistance to penicillin in Streptococcus pneumoniae involves remodelling of penicillin-binding proteins (PBPs), enzymes involved in the last stages of peptidoglycan (PGN) synthesis, which reduce the affinity of these targets to the antibiotic. However, the peptidoglycan composition has an important role in the expression of resistance to this antibiotic. The murMN operon in particular seems to play a critical role, since deletion lead to the complete abolishment of penicillin resistance, even in the presence of the remodelled PBPs. (...)"Filipe, Sérgio RaposoRUNNarciso, Ana Rita da Cruz2022-01-04T01:30:26Z2018-122018-12-01T00:00:00Zdoctoral thesisinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10362/94060enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T17:43:57Zoai:run.unl.pt:10362/94060Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T17:43:57Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Peptidoglycan synthesis and penicillin resistance in Streptococcus pneumoniae
title Peptidoglycan synthesis and penicillin resistance in Streptococcus pneumoniae
spellingShingle Peptidoglycan synthesis and penicillin resistance in Streptococcus pneumoniae
Narciso, Ana Rita da Cruz
penicillin resistance
Streptococcus pneumoniae
Biology
title_short Peptidoglycan synthesis and penicillin resistance in Streptococcus pneumoniae
title_full Peptidoglycan synthesis and penicillin resistance in Streptococcus pneumoniae
title_fullStr Peptidoglycan synthesis and penicillin resistance in Streptococcus pneumoniae
title_full_unstemmed Peptidoglycan synthesis and penicillin resistance in Streptococcus pneumoniae
title_sort Peptidoglycan synthesis and penicillin resistance in Streptococcus pneumoniae
author Narciso, Ana Rita da Cruz
author_facet Narciso, Ana Rita da Cruz
author_role author
dc.contributor.none.fl_str_mv Filipe, Sérgio Raposo
RUN
dc.contributor.author.fl_str_mv Narciso, Ana Rita da Cruz
dc.subject.por.fl_str_mv penicillin resistance
Streptococcus pneumoniae
Biology
topic penicillin resistance
Streptococcus pneumoniae
Biology
description "Resistance to penicillin in Streptococcus pneumoniae involves remodelling of penicillin-binding proteins (PBPs), enzymes involved in the last stages of peptidoglycan (PGN) synthesis, which reduce the affinity of these targets to the antibiotic. However, the peptidoglycan composition has an important role in the expression of resistance to this antibiotic. The murMN operon in particular seems to play a critical role, since deletion lead to the complete abolishment of penicillin resistance, even in the presence of the remodelled PBPs. (...)"
publishDate 2018
dc.date.none.fl_str_mv 2018-12
2018-12-01T00:00:00Z
2022-01-04T01:30:26Z
dc.type.driver.fl_str_mv doctoral thesis
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/94060
url http://hdl.handle.net/10362/94060
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
_version_ 1817545730763522048

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