Inhibition of human neutrophil oxidative burst by pyrazolone derivatives
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/20057 |
Resumo: | The risk of agranulocytosis associated with the use of pyrazolone drugs at therapeutical doses and for short periods of time has been considered to be very low. However, little or no attention at all has been devoted to the possible hindrance of neutrophil burst and scavenging of neutrophilgenerated reactive oxygen species (ROS) by these compounds. Such an effect could be beneficial in the case of overactivation of neutrophils but could also be highly detrimental if the number of circulating neutrophils is already decreased. Thus, the aim of the present study was to evaluate the putative inhibitory effect of the pyrazolones dipyrone, aminopyrine, isopropylantipyrine, and antipyrine against human neutrophil burst and their scavenging activity against O2 S!, H2O2, HOS, ROOS, and HOCl. The obtained results showed that dipyrone and aminopyrine prevent phorbol-12-myristate-13-acetate-induced neutrophil burst with high efficiency, while isopropylantipyrine had little effect and antipyrine had no effect at all. Dipyrone and aminopyrine were highly potent scavengers of HOS and HOCl, while, in accordance with the neutrophil burst results, isopropylantipyrine had little effect and antipyrine had no effect at all against these two ROS. None of the studied pyrazolones was capable of scavenging O2 S! or H2O2, while dipyrone was shown to be the most reactive against ROOS. |
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Inhibition of human neutrophil oxidative burst by pyrazolone derivativesHuman neutrophilsOxidative burstMyeloperoxidaseNADPH oxidaseReactive oxygen speciesPyrazolone derivativesDipyroneAminopyrineIsopropylantipyrineAntipyrineFree radicalsScience & TechnologyThe risk of agranulocytosis associated with the use of pyrazolone drugs at therapeutical doses and for short periods of time has been considered to be very low. However, little or no attention at all has been devoted to the possible hindrance of neutrophil burst and scavenging of neutrophilgenerated reactive oxygen species (ROS) by these compounds. Such an effect could be beneficial in the case of overactivation of neutrophils but could also be highly detrimental if the number of circulating neutrophils is already decreased. Thus, the aim of the present study was to evaluate the putative inhibitory effect of the pyrazolones dipyrone, aminopyrine, isopropylantipyrine, and antipyrine against human neutrophil burst and their scavenging activity against O2 S!, H2O2, HOS, ROOS, and HOCl. The obtained results showed that dipyrone and aminopyrine prevent phorbol-12-myristate-13-acetate-induced neutrophil burst with high efficiency, while isopropylantipyrine had little effect and antipyrine had no effect at all. Dipyrone and aminopyrine were highly potent scavengers of HOS and HOCl, while, in accordance with the neutrophil burst results, isopropylantipyrine had little effect and antipyrine had no effect at all against these two ROS. None of the studied pyrazolones was capable of scavenging O2 S! or H2O2, while dipyrone was shown to be the most reactive against ROOS.Elsevier 1Universidade do MinhoCosta, DavidMarques, A. P.Reis, R. L.Lima, José L. F. C.Fernandes, Eduarda20062006-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/20057eng0891-584910.1016/j.freeradbiomed.2005.09.01716458194info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-25T02:07:14Zoai:repositorium.sdum.uminho.pt:1822/20057Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-25T02:07:14Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Inhibition of human neutrophil oxidative burst by pyrazolone derivatives |
title |
Inhibition of human neutrophil oxidative burst by pyrazolone derivatives |
spellingShingle |
Inhibition of human neutrophil oxidative burst by pyrazolone derivatives Costa, David Human neutrophils Oxidative burst Myeloperoxidase NADPH oxidase Reactive oxygen species Pyrazolone derivatives Dipyrone Aminopyrine Isopropylantipyrine Antipyrine Free radicals Science & Technology |
title_short |
Inhibition of human neutrophil oxidative burst by pyrazolone derivatives |
title_full |
Inhibition of human neutrophil oxidative burst by pyrazolone derivatives |
title_fullStr |
Inhibition of human neutrophil oxidative burst by pyrazolone derivatives |
title_full_unstemmed |
Inhibition of human neutrophil oxidative burst by pyrazolone derivatives |
title_sort |
Inhibition of human neutrophil oxidative burst by pyrazolone derivatives |
author |
Costa, David |
author_facet |
Costa, David Marques, A. P. Reis, R. L. Lima, José L. F. C. Fernandes, Eduarda |
author_role |
author |
author2 |
Marques, A. P. Reis, R. L. Lima, José L. F. C. Fernandes, Eduarda |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Costa, David Marques, A. P. Reis, R. L. Lima, José L. F. C. Fernandes, Eduarda |
dc.subject.por.fl_str_mv |
Human neutrophils Oxidative burst Myeloperoxidase NADPH oxidase Reactive oxygen species Pyrazolone derivatives Dipyrone Aminopyrine Isopropylantipyrine Antipyrine Free radicals Science & Technology |
topic |
Human neutrophils Oxidative burst Myeloperoxidase NADPH oxidase Reactive oxygen species Pyrazolone derivatives Dipyrone Aminopyrine Isopropylantipyrine Antipyrine Free radicals Science & Technology |
description |
The risk of agranulocytosis associated with the use of pyrazolone drugs at therapeutical doses and for short periods of time has been considered to be very low. However, little or no attention at all has been devoted to the possible hindrance of neutrophil burst and scavenging of neutrophilgenerated reactive oxygen species (ROS) by these compounds. Such an effect could be beneficial in the case of overactivation of neutrophils but could also be highly detrimental if the number of circulating neutrophils is already decreased. Thus, the aim of the present study was to evaluate the putative inhibitory effect of the pyrazolones dipyrone, aminopyrine, isopropylantipyrine, and antipyrine against human neutrophil burst and their scavenging activity against O2 S!, H2O2, HOS, ROOS, and HOCl. The obtained results showed that dipyrone and aminopyrine prevent phorbol-12-myristate-13-acetate-induced neutrophil burst with high efficiency, while isopropylantipyrine had little effect and antipyrine had no effect at all. Dipyrone and aminopyrine were highly potent scavengers of HOS and HOCl, while, in accordance with the neutrophil burst results, isopropylantipyrine had little effect and antipyrine had no effect at all against these two ROS. None of the studied pyrazolones was capable of scavenging O2 S! or H2O2, while dipyrone was shown to be the most reactive against ROOS. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006 2006-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/20057 |
url |
https://hdl.handle.net/1822/20057 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0891-5849 10.1016/j.freeradbiomed.2005.09.017 16458194 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier 1 |
publisher.none.fl_str_mv |
Elsevier 1 |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
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1817545073437442048 |