Pushing the Limits of EEG: Estimation of Large-Scale Functional Brain Networks and Their Dynamics Validated by Simultaneous fMRI

Detalhes bibliográficos
Autor(a) principal: Abreu, Rodolfo
Data de Publicação: 2020
Outros Autores: Simões, Marco, Castelo-Branco, Miguel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/106116
https://doi.org/10.3389/fnins.2020.00323
Resumo: Functional magnetic resonance imaging (fMRI) is the technique of choice for detecting large-scale functional brain networks and to investigate their dynamics. Because fMRI measures brain activity indirectly, electroencephalography (EEG) has been recently considered a feasible tool for detecting such networks, particularly the resting-state networks (RSNs). However, a truly unbiased validation of such claims is still missing, which can only be accomplished by using simultaneously acquired EEG and fMRI data, due to the spontaneous nature of the activity underlying the RSNs. Additionally, EEG is still poorly explored for the purpose of mapping task-specific networks, and no studies so far have been focused on investigating networks' dynamic functional connectivity (dFC) with EEG. Here, we started by validating RSNs derived from the continuous reconstruction of EEG sources by directly comparing them with those derived from simultaneous fMRI data of 10 healthy participants, and obtaining an average overlap (quantified by the Dice coefficient) of 0.4. We also showed the ability of EEG to map the facial expressions processing network (FEPN), highlighting regions near the posterior superior temporal sulcus, where the FEPN is anchored. Then, we measured the dFC using EEG for the first time in this context, estimated dFC brain states using dictionary learning, and compared such states with those obtained from the fMRI. We found a statistically significant match between fMRI and EEG dFC states, and determined the existence of two matched dFC states which contribution over time was associated with the brain activity at the FEPN, showing that the dynamics of FEPN can be captured by both fMRI and EEG. Our results push the limits of EEG toward being used as a brain imaging tool, while supporting the growing literature on EEG correlates of (dynamic) functional connectivity measured with fMRI, and providing novel insights into the coupling mechanisms underlying the two imaging techniques.
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spelling Pushing the Limits of EEG: Estimation of Large-Scale Functional Brain Networks and Their Dynamics Validated by Simultaneous fMRIsimultaneous EEG-fMRIlarge-scale functional brain networksdynamic functional connectivity (dFNC)electrical source imaging (ESI), task-based fMRIresting-state functional network connectivity (rs-FNC)Functional magnetic resonance imaging (fMRI) is the technique of choice for detecting large-scale functional brain networks and to investigate their dynamics. Because fMRI measures brain activity indirectly, electroencephalography (EEG) has been recently considered a feasible tool for detecting such networks, particularly the resting-state networks (RSNs). However, a truly unbiased validation of such claims is still missing, which can only be accomplished by using simultaneously acquired EEG and fMRI data, due to the spontaneous nature of the activity underlying the RSNs. Additionally, EEG is still poorly explored for the purpose of mapping task-specific networks, and no studies so far have been focused on investigating networks' dynamic functional connectivity (dFC) with EEG. Here, we started by validating RSNs derived from the continuous reconstruction of EEG sources by directly comparing them with those derived from simultaneous fMRI data of 10 healthy participants, and obtaining an average overlap (quantified by the Dice coefficient) of 0.4. We also showed the ability of EEG to map the facial expressions processing network (FEPN), highlighting regions near the posterior superior temporal sulcus, where the FEPN is anchored. Then, we measured the dFC using EEG for the first time in this context, estimated dFC brain states using dictionary learning, and compared such states with those obtained from the fMRI. We found a statistically significant match between fMRI and EEG dFC states, and determined the existence of two matched dFC states which contribution over time was associated with the brain activity at the FEPN, showing that the dynamics of FEPN can be captured by both fMRI and EEG. Our results push the limits of EEG toward being used as a brain imaging tool, while supporting the growing literature on EEG correlates of (dynamic) functional connectivity measured with fMRI, and providing novel insights into the coupling mechanisms underlying the two imaging techniques.This work was supported by Grants Funded by Fundação para a Ciência e Tecnologia, PAC –286 MEDPERSYST, POCI-01-0145- FEDER-016428, BIGDATIMAGE, CENTRO-01-0145-FEDER- 000016 financed by Centro 2020 FEDER, COMPETE, FCT UID/4539/2013 – COMPETE, POCI-01-0145-FEDER-007440, and CONNECT.BCI POCI-01-0145-FEDER-308522020info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/106116http://hdl.handle.net/10316/106116https://doi.org/10.3389/fnins.2020.00323eng1662-4548Abreu, RodolfoSimões, MarcoCastelo-Branco, Miguelinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-04-06T10:20:29Zoai:estudogeral.uc.pt:10316/106116Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:22:34.927741Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Pushing the Limits of EEG: Estimation of Large-Scale Functional Brain Networks and Their Dynamics Validated by Simultaneous fMRI
title Pushing the Limits of EEG: Estimation of Large-Scale Functional Brain Networks and Their Dynamics Validated by Simultaneous fMRI
spellingShingle Pushing the Limits of EEG: Estimation of Large-Scale Functional Brain Networks and Their Dynamics Validated by Simultaneous fMRI
Abreu, Rodolfo
simultaneous EEG-fMRI
large-scale functional brain networks
dynamic functional connectivity (dFNC)
electrical source imaging (ESI), task-based fMRI
resting-state functional network connectivity (rs-FNC)
title_short Pushing the Limits of EEG: Estimation of Large-Scale Functional Brain Networks and Their Dynamics Validated by Simultaneous fMRI
title_full Pushing the Limits of EEG: Estimation of Large-Scale Functional Brain Networks and Their Dynamics Validated by Simultaneous fMRI
title_fullStr Pushing the Limits of EEG: Estimation of Large-Scale Functional Brain Networks and Their Dynamics Validated by Simultaneous fMRI
title_full_unstemmed Pushing the Limits of EEG: Estimation of Large-Scale Functional Brain Networks and Their Dynamics Validated by Simultaneous fMRI
title_sort Pushing the Limits of EEG: Estimation of Large-Scale Functional Brain Networks and Their Dynamics Validated by Simultaneous fMRI
author Abreu, Rodolfo
author_facet Abreu, Rodolfo
Simões, Marco
Castelo-Branco, Miguel
author_role author
author2 Simões, Marco
Castelo-Branco, Miguel
author2_role author
author
dc.contributor.author.fl_str_mv Abreu, Rodolfo
Simões, Marco
Castelo-Branco, Miguel
dc.subject.por.fl_str_mv simultaneous EEG-fMRI
large-scale functional brain networks
dynamic functional connectivity (dFNC)
electrical source imaging (ESI), task-based fMRI
resting-state functional network connectivity (rs-FNC)
topic simultaneous EEG-fMRI
large-scale functional brain networks
dynamic functional connectivity (dFNC)
electrical source imaging (ESI), task-based fMRI
resting-state functional network connectivity (rs-FNC)
description Functional magnetic resonance imaging (fMRI) is the technique of choice for detecting large-scale functional brain networks and to investigate their dynamics. Because fMRI measures brain activity indirectly, electroencephalography (EEG) has been recently considered a feasible tool for detecting such networks, particularly the resting-state networks (RSNs). However, a truly unbiased validation of such claims is still missing, which can only be accomplished by using simultaneously acquired EEG and fMRI data, due to the spontaneous nature of the activity underlying the RSNs. Additionally, EEG is still poorly explored for the purpose of mapping task-specific networks, and no studies so far have been focused on investigating networks' dynamic functional connectivity (dFC) with EEG. Here, we started by validating RSNs derived from the continuous reconstruction of EEG sources by directly comparing them with those derived from simultaneous fMRI data of 10 healthy participants, and obtaining an average overlap (quantified by the Dice coefficient) of 0.4. We also showed the ability of EEG to map the facial expressions processing network (FEPN), highlighting regions near the posterior superior temporal sulcus, where the FEPN is anchored. Then, we measured the dFC using EEG for the first time in this context, estimated dFC brain states using dictionary learning, and compared such states with those obtained from the fMRI. We found a statistically significant match between fMRI and EEG dFC states, and determined the existence of two matched dFC states which contribution over time was associated with the brain activity at the FEPN, showing that the dynamics of FEPN can be captured by both fMRI and EEG. Our results push the limits of EEG toward being used as a brain imaging tool, while supporting the growing literature on EEG correlates of (dynamic) functional connectivity measured with fMRI, and providing novel insights into the coupling mechanisms underlying the two imaging techniques.
publishDate 2020
dc.date.none.fl_str_mv 2020
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/106116
http://hdl.handle.net/10316/106116
https://doi.org/10.3389/fnins.2020.00323
url http://hdl.handle.net/10316/106116
https://doi.org/10.3389/fnins.2020.00323
dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 1662-4548
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dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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