The Role of the Pallidothalamic Fibre Tracts in Deep Brain Stimulation for Dystonia: A Diffusion MRI Tractography Study
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://repositorio.inesctec.pt/handle/123456789/6355 http://dx.doi.org/10.1002/hbm.23450 |
Resumo: | Background: Deep Brain Stimulation (DBS) of the Globus pallidus internus (GPi) is gold standard treatment in medically refractory dystonia. Recent evidence indicates that stimulation effects are also due to axonal modulation and affection of a fibre network. For the GPi, the pallidothalamic tracts are known to be the major motor efferent pathways. The aim of this study is to explore the anatomic vicinity of these tracts and DBS electrodes in dystonia applying diffusion tractography. Methods: Diffusion MRI was acquired in ten patients presenting for DBS for dystonia. We applied both a conventionally used probabilistic tractography algorithm (FSL) as well as a probabilistic streamline tracking approach, based on constrained spherical deconvolution and particle filtering with anatomic priors, to the datasets. DBS electrodes were coregistered to the diffusion datasets. Results: We were able to delineate the pallidothalamic tracts in all patients. Using the streamline approach, we were able to distinguish between the two sub-components of the tracts, the ansa lenticularis and the fasciculus lenticularis. Clinically efficient DBS electrodes displayed a close anatomic vicinity pathway of the pallidothalamic tracts, and their course was consistent with previous tracer labelling studies. Although we present only anatomic data, we interpret these findings as evidence of the possible involvement of fibre tracts to the clinical effect in DBS. Electro-physiological intraoperative recordings would be needed to complement our findings. In the future, a clear and individual delineation of the pallidothalamic tracts could optimize the stereotactic process of optimal electrode localization. (C) 2016 Wiley Periodicals, Inc. |
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The Role of the Pallidothalamic Fibre Tracts in Deep Brain Stimulation for Dystonia: A Diffusion MRI Tractography StudyBackground: Deep Brain Stimulation (DBS) of the Globus pallidus internus (GPi) is gold standard treatment in medically refractory dystonia. Recent evidence indicates that stimulation effects are also due to axonal modulation and affection of a fibre network. For the GPi, the pallidothalamic tracts are known to be the major motor efferent pathways. The aim of this study is to explore the anatomic vicinity of these tracts and DBS electrodes in dystonia applying diffusion tractography. Methods: Diffusion MRI was acquired in ten patients presenting for DBS for dystonia. We applied both a conventionally used probabilistic tractography algorithm (FSL) as well as a probabilistic streamline tracking approach, based on constrained spherical deconvolution and particle filtering with anatomic priors, to the datasets. DBS electrodes were coregistered to the diffusion datasets. Results: We were able to delineate the pallidothalamic tracts in all patients. Using the streamline approach, we were able to distinguish between the two sub-components of the tracts, the ansa lenticularis and the fasciculus lenticularis. Clinically efficient DBS electrodes displayed a close anatomic vicinity pathway of the pallidothalamic tracts, and their course was consistent with previous tracer labelling studies. Although we present only anatomic data, we interpret these findings as evidence of the possible involvement of fibre tracts to the clinical effect in DBS. Electro-physiological intraoperative recordings would be needed to complement our findings. In the future, a clear and individual delineation of the pallidothalamic tracts could optimize the stereotactic process of optimal electrode localization. (C) 2016 Wiley Periodicals, Inc.2018-01-16T12:40:59Z2017-01-01T00:00:00Z2017info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://repositorio.inesctec.pt/handle/123456789/6355http://dx.doi.org/10.1002/hbm.23450engRozanski,VENádia Moreira SilvaAhmadi,SAMehrkens,JJoão Paulo CunhaHoude,JCVollmar,CBotzel,KDescoteaux,Minfo:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-05-15T10:19:55Zoai:repositorio.inesctec.pt:123456789/6355Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:52:26.053211Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The Role of the Pallidothalamic Fibre Tracts in Deep Brain Stimulation for Dystonia: A Diffusion MRI Tractography Study |
title |
The Role of the Pallidothalamic Fibre Tracts in Deep Brain Stimulation for Dystonia: A Diffusion MRI Tractography Study |
spellingShingle |
The Role of the Pallidothalamic Fibre Tracts in Deep Brain Stimulation for Dystonia: A Diffusion MRI Tractography Study Rozanski,VE |
title_short |
The Role of the Pallidothalamic Fibre Tracts in Deep Brain Stimulation for Dystonia: A Diffusion MRI Tractography Study |
title_full |
The Role of the Pallidothalamic Fibre Tracts in Deep Brain Stimulation for Dystonia: A Diffusion MRI Tractography Study |
title_fullStr |
The Role of the Pallidothalamic Fibre Tracts in Deep Brain Stimulation for Dystonia: A Diffusion MRI Tractography Study |
title_full_unstemmed |
The Role of the Pallidothalamic Fibre Tracts in Deep Brain Stimulation for Dystonia: A Diffusion MRI Tractography Study |
title_sort |
The Role of the Pallidothalamic Fibre Tracts in Deep Brain Stimulation for Dystonia: A Diffusion MRI Tractography Study |
author |
Rozanski,VE |
author_facet |
Rozanski,VE Nádia Moreira Silva Ahmadi,SA Mehrkens,J João Paulo Cunha Houde,JC Vollmar,C Botzel,K Descoteaux,M |
author_role |
author |
author2 |
Nádia Moreira Silva Ahmadi,SA Mehrkens,J João Paulo Cunha Houde,JC Vollmar,C Botzel,K Descoteaux,M |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Rozanski,VE Nádia Moreira Silva Ahmadi,SA Mehrkens,J João Paulo Cunha Houde,JC Vollmar,C Botzel,K Descoteaux,M |
description |
Background: Deep Brain Stimulation (DBS) of the Globus pallidus internus (GPi) is gold standard treatment in medically refractory dystonia. Recent evidence indicates that stimulation effects are also due to axonal modulation and affection of a fibre network. For the GPi, the pallidothalamic tracts are known to be the major motor efferent pathways. The aim of this study is to explore the anatomic vicinity of these tracts and DBS electrodes in dystonia applying diffusion tractography. Methods: Diffusion MRI was acquired in ten patients presenting for DBS for dystonia. We applied both a conventionally used probabilistic tractography algorithm (FSL) as well as a probabilistic streamline tracking approach, based on constrained spherical deconvolution and particle filtering with anatomic priors, to the datasets. DBS electrodes were coregistered to the diffusion datasets. Results: We were able to delineate the pallidothalamic tracts in all patients. Using the streamline approach, we were able to distinguish between the two sub-components of the tracts, the ansa lenticularis and the fasciculus lenticularis. Clinically efficient DBS electrodes displayed a close anatomic vicinity pathway of the pallidothalamic tracts, and their course was consistent with previous tracer labelling studies. Although we present only anatomic data, we interpret these findings as evidence of the possible involvement of fibre tracts to the clinical effect in DBS. Electro-physiological intraoperative recordings would be needed to complement our findings. In the future, a clear and individual delineation of the pallidothalamic tracts could optimize the stereotactic process of optimal electrode localization. (C) 2016 Wiley Periodicals, Inc. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-01-01T00:00:00Z 2017 2018-01-16T12:40:59Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
format |
article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.inesctec.pt/handle/123456789/6355 http://dx.doi.org/10.1002/hbm.23450 |
url |
http://repositorio.inesctec.pt/handle/123456789/6355 http://dx.doi.org/10.1002/hbm.23450 |
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eng |
language |
eng |
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info:eu-repo/semantics/embargoedAccess |
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embargoedAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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